Protein Alignment Exn and RhoGEF4

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_648101.1
• Gene: RhoGEF4 / 38806
• FlyBaseID: FBgn0035761
• Length: 647
• Species: Drosophila melanogaster
• Alignment Length: 389
• Identity: 83/389 - (21%)
• Similarity: 154/389 - (39%)
• Gaps: 92/389 - (23%)

  Fly  1470 TGNEAGLGDELSSEPHS--LFSNEPLYQ------MYSAAKLESITRDLEAHGSSDGYEEIGLQAK 1526
            |..:.|.|:.....|.:  .||.| |.|      :.:|.....:...|:::.||
  Fly     3 TPRQKGYGNGFIHSPQTPLSFSRE-LRQVLQERNLLTAKSRRKVCSMLDSNNSS----------- 55

  Fly  1527 AKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYL 1591
                |:..|.|.|.:                          .|..|.:::|    |||:||.|||
  Fly    56 ----PIGSPNPDAGK--------------------------RLGFRRQAIQ----EIISSEKSYL 86

  Fly  1592 KSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCI 1656
            :.|.||...|:  ....:.:::...:...||..|..:|..:...|.||||..::      ::...
  Fly    87 EQLELLMNFFV--RPLKEQAIIDCSNHTLLFGQIEMIHNLNGEFLRELEANMEN------VAHAF 143

  Fly  1657 YEIAERHFHVYVAFC-EHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQ 1720
            .::|. .|.:|..:. :::|.:......:.::.   .|::.||:.|:.|. ....|:|.:::|:|
  Fly   144 LKMAP-FFKLYSVYAFDYRGALFIIQDLISKNP---VFRKFLEQTESRPE-VQRKLNSLMIVPIQ 203

  Fly  1721 RITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPS 1785
            |:.|..||::.|....||.: .:|:       |:::.|.:....|:......|.:.|.:.|   .
  Fly   204 RVPRYKLLLEQVLLYTSPAD-ADYK-------LLKESVKEIEATASHINTCVEEQEITQYL---I 257

  Fly  1786 HVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK 1849
            |::...:.  ..|......|.::|.|.|..:..:|           |:|..|..|.||:.:.||
  Fly   258 HLQNSLVN--RTPNIVKPSRRVIKEGVLQKITHKG-----------TEIKRYCVLMSDIFMYCK 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/182 (24%)
		PH_ephexin	1805..1931	CDD:269929	13/45 (29%)
		SH3_ephexin1_like	1944..1998	CDD:212727
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	46/194 (24%)
		PH-like	269..>311	CDD:302622	13/51 (25%)
		PH	277..374	CDD:278594	12/43 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810