DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and RhoGEF64C

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster

Alignment Length:	2031	Identity:	364/2031 - (17%)
Similarity:	631/2031 - (31%)	Gaps:	760/2031 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 KSYNS--KALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRAKREHNRLEGLSLSAASAQ 301
            ||::.  |.|.:.|.|.|.|...|.:..:|.:         :::...:::|.:|:.........|
  Fly     7 KSWSQRLKTLGSGDSVDKNASLAAVSGMQAMQ---------QLQLHMQQQHQQLQQHQQQLQQQQ 62

  Fly   302 SGGSSES-------LQTTTTSSSTPTTHSS-VTSSTGRSGGRRKYS----FKTHAG----KSYHQ 350
            .....:.       .|..|.....|...:. :.|:..||   .||:    :.|..|    .||..
  Fly    63 QQQQQQQHMAHHGHPQMLTAYQLPPVPAAEFLPSALSRS---MKYAEPWIYGTVRGIPARPSYGY 124

  Fly   351 HHHPSRRTSNMDSSNG--GISMVAKLTHQFNEIIQKDAKLLEQVKRNNGVWISR----------G 403
            |.|.:...:..:...|  .:::|.....::....::|.|.....|:..|   ||          |
  Fly   125 HPHAAAIFAATEGVPGTTALAVVICSCAEYLNGTKRDVKKASVCKKCKG---SRLPLATIGGTGG 186

  Fly   404 THVYKIVEKPTSEGKGLPNADDNRISTVQRNIKKFERLEKPSV--PLKSEQLMRKHLELM----- 461
            |     |..|...|    ::...|.......:....:..:||:  |.|....:.:...|:
  Fly   187 T-----VRLPAVSG----SSSSRRPMAATMRVVSATKKSRPSILDPQKDPYDLMRRTRLLSPEPS 242

  Fly   462 ----------RGSSLSRGPRIKRNLKLPPGSVGI---PELAIVSEELKTPTS----EEQAKKPKS 509
                      |..:::..||.:...:.||....|   |.:| |...:..||.    |:.....:|
  Fly   243 SKEADSKSRSRSETVANQPRGRTRTRAPPPPAPIQKSPAVA-VPTAVPDPTDCWLMEDNESLLQS 306

  Fly   510 VQNESQPN----------HPEELNQSND--------KPSDELDLIMGEEGDEEELRQKQRKHKYA 556
            ....|:.|          :|.:|..|.:        ||:|..|:...:..|:|   ..:||.|..
  Fly   307 SGLASRANSRRSILRCHVNPYDLISSENGKLHSNLRKPNDHFDVADAQLNDDE---LGERKSKGT 368

  Fly   557 SIYEKLRFTFAKGRK---------SASPSPTKAQIREEVSIDEESIKDSTSEDMVTRKEDFTLDL 612
            |.:.........|::         |:.|..:..:| ..||..|.:..:........:|.|...::
  Fly   369 SKFYSGNVAAIAGQRISLGDKSGDSSDPGDSYERI-IMVSGGESTASNGPRRPPRNKKADEPAEM 432

  Fly   613 P------------------------KEVIPRA----------EDLEDSSHALLVSPCFEADAKIL 643
            |                        ..|.|:|          :|.|.:...|.|:|...|...||
  Fly   433 PAAAGAAGAAGAAATSPPAAAVTAATAVKPKAVTLAKVEKIEKDNESAYTVLTVTPTSPAIKSIL 497

  Fly   644 D-----ALEAVDLKLKVLNPLND--VTTADGERELLL------AANDDFEQRILPNSSFVYQAAN 695
            .     .|..|.:....|.|:|:  :.|..|:.:..:      ||.        |.||....|.:
  Fly   498 KRPTTLELPGVGMSPLPLPPVNNSGLVTPAGKSQFYIPTPTGTAAT--------PTSSSTPMATS 554

  Fly   696 KQYSNNQILLNQAVNVTLVNAIEGE----------QMIMEQKQLMKVRDLELTERDID------- 743
            ....|        .::|...|..|.          |.::|.|.:........|: |.|
  Fly   555 TPTPN--------ASITATTAAAGAAITPGSRKKVQFMVEDKIIATTATAATTD-DSDASAVATK 610

  Fly   744 ----------------------------QPLKRAEKSPEKDDTL--------------------- 759
                                        .|...|..:.:::.||
  Fly   611 TNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEATLFAADIDDEHNFTTSGEAAPPF 675

  Fly   760 -EPESL-YEPITP---VMDETKTEAQ--------------------------------------- 780
             :|:|| ||.:.|   :.|.:::.|:
  Fly   676 IKPDSLHYEDVLPGPQIFDSSESSAKLSLPADGSPHVTTSPVSVLPTGTSNGVGGAGLGPGPAGV 740

  Fly   781 -------TSSLFKIYTKKSELVEDIYQTVEEAS----TVEVKPNNWLEGYESIAGSQE------- 827
                   |::.....|:|:......|...:|.:    :.:.|||:..|..:...|.:|
  Fly   741 SGEEAPATAAATAAATQKTTAANRDYDDDDEHNDKDESHDNKPNDLAEREQDREGDKEQGRAGEL 805

  Fly   828 -----------------------------------------ACPLTYDGYES---FAPEEVVTTP 848
                                                     ..||...|:.|   .|.....:.|
  Fly   806 GISRQEKKDAGGKPAASQKRAAQTTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIP 870

  Fly   849 TTPSATG----------TLG-------RNTRD-------ELPELPKPK----------RVLNKSP 879
            .||.|:|          |:.       .::||       |.|..|.||          ..:||||
  Fly   871 MTPPASGPQNVILNFKDTMALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEINKSP 935

  Fly   880 IP-----LRPAPPKPQAKE-------------------SEED----------ENIYDTIKGCYES 910
            :.     :|.||.|||.::                   ||||          .|::.:..| .|.
  Fly   936 LSPQRTVVRVAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPG-EED 999

  Fly   911 MHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTI 975
            ...|.||...||:...:  |::||:|..:.   :.:|.|..   ..|.:...||.:||:.
  Fly  1000 AAPKKTSILISGDDCYS--TMNLSANAAQP---LYQSSVVV---NSHSATSVCISVSSAE----- 1051

  Fly   976 SSDHKTNSL-----YESSLAAAGCVVYGSA------SVGCRSSLGSSAGSRDSGKPGDKRSSI-- 1027
            ..:.:.|.|     .:..:..|...:.|::      ||.|.||..||:.|..|...|..|:.|
  Fly  1052 EQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRTLIRL 1116

  Fly  1028 ------AGSSDNSDAWVDISDGEIGQAT------TDATANEAQFIV----------------VRE 1064
                  .||:.:|   ..|:...:..:|      ||.....|..:|                |:.
  Fly  1117 DYDRERKGSATSS---TPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRNPVEAVKL 1178

  Fly  1065 RFKPH------RTRSPDWSKRIRDK--------------RLQQKKAISCIEDDSDHYYETLSPL- 1108
            ...||      .||....||:|:::              :|.|...:..:.:..:  .||::.|
  Fly  1179 NLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLE--TETVAELI 1241

  Fly  1109 -----------------GNKRH---------STQLVRQSQDGNRSG------GVRSSHR---RSK 1138
                             |.|.|         |.|.:|..:.....|      ..|.|:|   .|.
  Fly  1242 ENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSA 1306

  Fly  1139 NHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYND---SGVDMRNHRLPKPPPPQNQ 1200
            |..||||          :|:.|:.|. ..|..|.|..|...::   ||:
  Fly  1307 NSFASAH----------NYELFDFDG-GAGGNESDCYQSCSSELTASGI---------------- 1344

  Fly  1201 VYEFVRKFKDFISSKKSPK-----GSQQKLYENTPASTLFYVECSKR--------TEDVYENTDF 1252
                  ..:|.:|..|.|:     .::.|.|:....:||..:|.|..        :|..||:...
  Fly  1345 ------LEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRH 1403

  Fly  1253 GPERIPAPETKGPVHQEQAPV-LRAKQKNGKSLRSRLRKSLV--GSSFDTKQLSSLAPTRSTFYV 1314
            ..:  |..|   .:|:...|: |.|...|...|..:..:|:.  .|.:|.          .::.|
  Fly  1404 SGD--PIYE---EIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDI----------LSYLV 1453

  Fly  1315 EDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPN 1379
            :..|..|..             :..|...|...:.|.....|::...|::|:
  Fly  1454 DAKERGLAR-------------EESFDYGNNPKIIEEEAADTLSDLDKRQAE------------- 1492

  Fly  1380 DPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSS 1444
                            :.||:.|:.|::.                     ..::|.|  |..:
  Fly  1493 ----------------ERERDRDSGQSSM---------------------SSLSPPP--HNFI-- 1516

  Fly  1445 WYAESGLYQTSGISVASSSGSSGVSTGN-----EAGLGDELSSEPHSLFSNEPLYQMYSAAKLES 1504
                              .|.:|.|:|:     ::|:|.|.|....|         .|.|.
  Fly  1517 ------------------CGGAGKSSGSDVERQDSGVGSETSKTSRS---------KYQAT---- 1550

  Fly  1505 ITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQL-------VEPKNGPSRTLWSEIPEVIH 1562
                                            ||.|.|       ||.:.|.:..|::  |.|..
  Fly  1551 --------------------------------PTVLHLCEDCDGAVEMQVGDNGILYA--PLVCR 1581

  Fly  1563 SCILPTLTSRER-SLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIV 1626
            .|      .::| ..:|...||:.:|..|.:.|.::...|.  :..|.:.:|:.:...|:|....
  Fly  1582 KC------GKKRVERKEIITEIVETEEKYGRDLQIILEEFC--HPMLVAGLLTQEQLSAIFLNTE 1638

  Fly  1627 PVHE----CSERLLTELEACWQ---DNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRL 1684
            .:.|    .:||:...|:...:   |:::.:.:.|...:..:. .|.:.::|..|......|..|
  Fly  1639 DLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQM-LHAFESYCVRQAGASLLLANL 1702

  Fly  1685 KESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKL 1749
            ::.||.|.....:.::| :.....:||:||||:|:||:|:.|||:..:: |.:|.:.|..|..|.
  Fly  1703 EKEKELLRIFLKVSQME-NAVLRRMNLNSFLMVPVQRVTKYPLLLARLY-KVTPSHLEGRELLKQ 1765

  Fly  1750 TLALVQKVVGQCNEAA 1765
            ....::..:...|:.|
  Fly  1766 AQEKIELHLNHINQEA 1781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	43/188 (23%)
		PH_ephexin	1805..1931	CDD:269929
		SH3_ephexin1_like	1944..1998	CDD:212727
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	43/190 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840