Protein Alignment Exn and POSH

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 113/557 - (20%)
• Similarity: 184/557 - (33%)
• Gaps: 187/557 - (33%)

  Fly  1502 LESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCIL 1566
            |..|...::.:.::...||.|.:.:.:|| ..||:|.|..:..|.|.                 |
  Fly    69 LMRILEGMKQNAAAGKGEEKGEETETQPE-RAKPQPPAESVAPPDNQ-----------------L 115

  Fly  1567 PTLTSRERSLQEAK--------------FEIITSEASYLKSLN---LLRRHFMNHNAFLDSSVLS 1614
            ..|.|.::|.|.|:              |:..:.||:.||...   :|.:|.:::|.|    |..
  Fly   116 LQLQSHQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWF----VGQ 176

  Fly  1615 AKDRKALF--SYI-----VPVHECSERLLTEL-----EACWQDNIMLLGLSRCIYEIAERHFHVY 1667
            |..::..|  :|:     :|:.:|......::     |.|.:..      ...:.::..|..|.:
  Fly   177 ANGQEGTFPINYVKVSVPLPMPQCIAMYDFKMGPNDEEGCLEFK------KSTVIQVMRRVDHNW 235

  Fly  1668 VAFCEHQGRMDRTL--------------RRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLP 1718
            .     :||:.:|:              ::|.:|                    ||:.|.|...|
  Fly   236 A-----EGRIGQTIGIFPIAFVELNAAAKKLLDS--------------------GLHTHPFCHPP 275

  Fly  1719 MQRITR----LPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIAR 1779
            .|:..|    :|::...|.::.|.             .......|..|.::..............
  Fly   276 KQQGQRALPPVPVIDPTVVTESSS-------------GSSNSTPGSSNSSSTSSSNNCSPNHQIS 327

  Fly  1780 QLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDL 1844
            ....|.||.|...|.|.....|||.    ||..|..||  |..|.|:
  Fly   328 LPNTPQHVVASGSASVRFRDKGAKE----KRHSLNALL--GGGAPLS------------------ 368

  Fly  1845 LLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVL 1909
            ||...|......|:    |..:..|....|....||.  ..|..:.|          :.||:
  Fly   369 LLQTNRHSAEILSL----PHELSRLEVSSSTALKPTS--APQTSRVL----------KTTVQ--- 414

  Fly  1910 SCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLP 1974
                        |.|:|   ..|       |.   .:|...|:..:.|.|:|:.|.|..|:.:..
  Fly   415 ------------QQMQP---NLP-------WG---YLALFPYKPRQTDELELKKGCVYIVTERCV 454

  Fly  1975 DGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQ 2011
            |||::|:...| ..|.|||:|...|     |||:.:|
  Fly   455 DGWFKGKNWLD-ITGVFPGNYLTPL-----RARDQQQ 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	35/213 (16%)
		PH_ephexin	1805..1931	CDD:269929	24/125 (19%)
		SH3_ephexin1_like	1944..1998	CDD:212727	18/53 (34%)
POSH	NP_523776.1	RAD18	6..>113	CDD:227719	12/44 (27%)
		RING-HC_SH3RF3	8..53	CDD:438408
		SH3	139..191	CDD:473055	13/55 (24%)
		SH3_SH3RF_2	199..251	CDD:212721	8/62 (13%)
		SH3_SH3RF_3	424..477	CDD:212717	18/56 (32%)
		SH3_SH3RF_C	782..836	CDD:212719