Protein Alignment Exn and Arhgef12

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001013264.2
• Gene: Arhgef12 / 367072
• RGDID: 1305111
• Length: 1545
• Species: Rattus norvegicus
• Alignment Length: 1311
• Identity: 255/1311 - (19%)
• Similarity: 443/1311 - (33%)
• Gaps: 399/1311 - (30%)

  Fly   810 VKPNNWLEGYESI-AGSQEACPLTYDGYESFAPE-----------------EVVTTPTTPSATGT 856
            |..:|.||..:.| :||..|  ||..|....:|:                 .::|:|.:|.|.|.
  Rat   122 VTHSNHLEVVKLIRSGSYVA--LTVQGRPPGSPQIPLAESEVEPSVIGHMSPIMTSPHSPGAAGN 184

  Fly   857 LGRNTRDELPELPKPKRVLNKSPIP-LRPAPPKPQAKES--EEDENIYDTIKGCYESMHCKATSS 918
            :.|.|...|  :.:...|::...:. ||....|.|.:..  :||.|
  Rat   185 MERITSPVL--MGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYN------------------- 228

  Fly   919 SSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSS-GSTLTISSDHKTN 982
                    .|.|..|.....|:..||.:.:...::..|....|:.|..|.. |..||:|.
  Rat   229 --------RTATQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVIAPSRPLGDALTLSE----- 280

  Fly   983 SLYESSLAAAGCVVYGSASVG---CRSSLGSSAGSRDSGKPGDK-RSSIAGS---SDNSDAWVDI 1040
                           .....|   ||:...|...||.|....|. :||:...   .|..:....:
  Rat   281 ---------------AETDPGDGLCRTDWSSGDASRPSSDSADSPKSSLKERVCLEDTPERTEGV 330

  Fly  1041 SDGE----IGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHY 1101
            .|.:    :|..:|              |..||                    .|...:||....
  Rat   331 QDADTQSLVGSPST--------------RGAPH--------------------IIGAEDDDFGTE 361

  Fly  1102 YETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVV------------IS 1154
            :|.::...:...|.:|::.          |.:|.....|         |||            .|
  Rat   362 HEQINGQCSCFQSIELLKS----------RPAHLAVFLH---------HVVSQFDPATLLCYLYS 407

  Fly  1155 DDYDSFETDSDD--------HG---DGEPDLRQRNYNDSGVDMRNHRLPKPPPP----------Q 1198
            |.|.  :|:|.:        |.   |....||.....:..||:...| |:..|.          |
  Rat   408 DLYK--QTNSKETRRVFLEFHQFFLDRSAHLRVSVPEEISVDLEKRR-PELIPEDLHRHYIQTMQ 469

  Fly  1199 NQVY-EFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPET 1262
            .:|: |..|..:||          :||   .:...||...|.:|.  |...:.|
  Rat   470 ERVHPEVQRHLEDF----------RQK---RSMGLTLAESELTKL--DAERDKD----------- 508

  Fly  1263 KGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFY-------VEDPEGS 1320
            :|.:.:|:|        ..:.:.:::.:.|:.:....::.||........|       |::|..
  Rat   509 RGTLEKERA--------CAEQIVTKIEEVLMTAQAVEEERSSTMQYVILMYMKHLGVKVKEPRN- 564

  Fly  1321 LPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPP 1385
                 ||   |..|.:  ||          .||.....:|.::..:..:||   |. |:...||.
  Rat   565 -----LE---HKRGRI--GF----------LPKIKQSMKKDREGEEKGKRR---GF-PSILGPPR 605

  Fly  1386 PPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESG 1450
            .|...:.|.:....|:...:...        ..:...::||...:|.....|   ||::...::|
  Rat   606 RPSRHDNSAIGRAMEIQKLRHPK--------HLSAPSSMSPELQDPAKLRQS---GVANEGTDTG 659

  Fly  1451 LYQTSGISVASSSGSSGVSTGNEAGLG--------------DELSSEPHSLFS-NEPLYQMYSAA 1500
            ....|.:|.|:|..:.....|.|...|              |.:...|:::|. ..||.......
  Rat   660 YLPASSMSSATSGAALSQEGGRENDTGAKQVGDAVAPGDCLDSIPRVPNTVFDFPPPLLDQVQEE 724

  Fly  1501 KLESITRDLEAHGSSDGYEEIGL----QAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVI 1561
            :.| :.|..| ||:...:.:...    :::::.|.......|     :|.|      |.::   :
  Rat   725 ECE-VERVAE-HGTPKPFRKFDSIAFGESQSEDEQFENDLET-----DPPN------WQQL---V 773

  Fly  1562 HSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIV 1626
            ...:|..|...|...||...|:..:|.:::::|.:|.:.|  :.......:||..:.:.:||.:.
  Rat   774 SREVLLGLKPSEIKRQEVINELFYTERAHVRTLKVLDQVF--YQRVSREGILSPSELRKIFSNLE 836

  Fly  1627 PVHECSERLLTELEACWQDN----IMLLGLSRCIYEIA---ERHFHVYVAFCEHQGRMDRTLRRL 1684
            .:.:....|..:::|..:.|    |..:|....::...   |:..|....||.:|   ...|..:
  Rat   837 DILQLHVGLNEQMKAVRKRNETSVIDHIGEDLLLWFSGPGEEKLKHAAATFCSNQ---PFALEMI 898

  Fly  1685 K-ESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWK 1748
            | ..|:...||..::..|::|.|..|.|...:...|||:|:.|||:|         |..:|..|.
  Rat   899 KSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLD---------NIAKYTEWP 954

  Fly  1749 LTLALVQKVVGQC-------NEAANRWEQAFELERIARQL--------EFPS--HVRALAIAPVG 1796
            .....|:|...||       |:|....|....||...|:|        |:|:  .:|.|.:.
  Rat   955 PEREKVKKAADQCRQILNYVNQAVREAENKQRLEDYQRRLDTSSLKLSEYPNVDELRNLDLT--- 1016

  Fly  1797 VPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGE----SCFS 1857
                   .|.::..|.   |:|:....|        .|.:|..|..|:|:|.:::.:    .|
  Rat  1017 -------KRKMIHEGP---LVWKVNRDK--------SIDLYTLLLEDILVLLQKQDDRLVLRC-- 1061

  Fly  1858 VFDYCPRSMLTLAAGDS------LPQLPTKDLKDQA--GKNLILMTLLEN-----------CDRK 1903
                  .|.:..:..||      :.:|.|..::..|  .|.|.::::.:|           ...|
  Rat  1062 ------HSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEK 1120

  Fly  1904 TVELVLSC---PSVSDQQ-RWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELG 1964
            ||...|.|   .||.:|. :.:...:||..|  |:.                :.:||..|::|..
  Rat  1121 TVWQDLICRMAASVKEQSTKPIPLPQPPPCE--GDN----------------DEEEPAKLKVEHH 1167

  Fly  1965 DVVNVSRKLPD 1975
            |:.....:.||
  Rat  1168 DLSVAGLQSPD 1178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/196 (22%)
		PH_ephexin	1805..1931	CDD:269929	31/152 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727	7/32 (22%)
Arhgef12	NP_001013264.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810