DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Arhgef28

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_038958459.1	Gene:	Arhgef28 / 361882	RGDID:	1307061	Length:	1714	Species:	Rattus norvegicus

Alignment Length:	1460	Identity:	262/1460 - (17%)
Similarity:	450/1460 - (30%)	Gaps:	515/1460 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   780 QTSSLFKIYTKKSELVEDIYQTVEEASTVEVKPNNWL------------EGYESI---AGSQEAC 829
            :.:..:.||....:....|...||:.....:.|.:||            |||..:   :||
  Rat    42 EDAEFYFIYDGSHQRHVVIADRVEDNVLQSIIPGHWLQETVMVSVCLCSEGYSPVTMGSGS---- 102

  Fly   830 PLTY-DGYESFAPEEVVT-----TPTTPSATGTLGRNTRDELP-------------ELPKPKRVL 875
             :|| |.........:||     ||.:.....|....|.:.||             |||....||
  Rat   103 -VTYVDNMACRLARLLVTQADRLTPCSHQTLLTPFALTAEALPALDEELVLALTQLELPLGWTVL 166

  Fly   876 NKSP------------IPLRPAPPK--------PQAKESEEDENIYDTIKGCYESMHCKATSSSS 920
            ..|.            :.:|.|.||        |...::.|..|         |........:..
  Rat   167 GNSSLEVCLHRESLLHLAVRWALPKLFHFLLCLPGGVKALELPN---------EEATTPLDLALH 222

  Fly   921 SGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLY 985
            .|.:.|..|..:.........|.:|.:..||            :|...|..|||::.:|....|.
  Rat   223 GGHSMLVEDISNFQGRRSPGFSRLRLNEDAT------------LQFDRSSETLTLTVNHTAEHLL 275

  Fly   986 ESSLAAAGCVVYGSA---------SVGCRSSLGSSAG-------SRDSGK-PGDK-------RSS 1026
            |:.:.......:..|         :...|:::.|.|.       :.:||: |.::       :|.
  Rat   276 EADIKLFRKYFWDRAFLVKALDQEAKTERATMPSGAAETEEEVRNLESGRSPSEEEEDGQLVKSQ 340

  Fly  1027 IAGSSDNSD------------------AWVDISDGEIGQATTDATANEAQFIVVRE--------- 1064
            ..|.|:..|                  |...::.|::...........|..:|:.:
  Rat   341 ADGPSEQEDQDRLVLDHSFDGLKKSKHAPASLAAGQLSDVPNGGDEVYANCMVIDQVGDLDINYI 405

  Fly  1065 -------RFKPHRTRS---PDWSKRI---------------RDKRLQQKKAISCIEDDSDH---- 1100
                   ...|...||   |...|.|               .|:.|....:.||:...|.|
  Rat   406 NIEGLSTHTSPESMRSTLGPQACKHILPPDTSPCGHLLCEDSDRTLDAAASQSCMSPPSSHTSNL 470

  Fly  1101 --------YYETLSPLGNKRHST--QLVRQSQDGNRSG-------GVRSSHRRSKNHSASAHTLG 1148
                    :.:..|.| .||.|:  .||..|::..||.       |.:||.|..
  Rat   471 NLSFGLHGFVKEQSHL-KKRSSSLDALVADSEEEGRSEPPICYAVGSQSSPRTG----------- 523

  Fly  1149 EHVVISDDYDSFETDSDDHGDGEPD--------------LRQRNYNDSGVDMRNHRLPKPPPPQN 1199
              :...|:.|||:.::      |||              |..:....||:..|::....|.....
  Rat   524 --LPGGDELDSFDANT------EPDCNISRTESLSLSSTLHSKESLLSGIRSRSYSCSSPKISSG 580

  Fly  1200 QVYEFVRKFKDFISSK-------KSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERI 1257
            : ...||.|....||:       :.|.| ::::.|......:...:.......|.....|...|:
  Rat   581 K-SRLVRDFTVCSSSEEQRSYSFQEPPG-EKRIQEEEWDDYIIPAKAESEKHKVSRTFSFLMNRM 643

  Fly  1258 PAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLP 1322
            .:|..|            :|.||.                |||....|  .|..|......|.|.
  Rat   644 TSPRNK------------SKMKNK----------------DTKDKEKL--NRHQFVPGTFSGVLQ 678

  Fly  1323 ALPLEPEIHGSGELD----SGFSDKNC--TPLPETPKFSTVARKAKKEAKANRRRTTIGLRP-ND 1380
            ....:..:.|...|.    ...:.|.|  |..|.|.||.....|       |:.:|.:|... .|
  Rat   679 CSGCDKTLLGKESLQCANCKANTHKGCKDTVPPCTKKFQDKYNK-------NKPQTILGSSSVRD 736

  Fly  1381 PPPP-----PPP------------MTGNKSPLD---PERELDAEQTTSWYAECGVFKQATNGAVS 1425
            .|||     |.|            ..|...||.   |...|::            |::|.....|
  Rat   737 VPPPGLSLHPSPSMPIGLPAGRKETAGQAHPLSRSVPGTTLES------------FRRAVTSLES 789

  Fly  1426 PRGDEPVTPTPSGHGGVSSWYAES---GLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSL 1487
                         .|..:||.:.|   .|:|:.|.|.::.|
  Rat   790 -------------EGDSNSWRSRSHSDELFQSMGSSPSTES------------------------ 817

  Fly  1488 FSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRT 1552
            |..|.:......::|.|..::.||..
  Rat   818 FMMEDVVDSSLWSELSSDAQEFEAES--------------------------------------- 843

  Fly  1553 LWSEIPEVIHSCILPTLTSRER----SLQEAKFEIITSEASYLKSLNLLRRHF---MNHNAFLDS 1610
             ||.:.:       |:..||:.    ..|:..||::.:|..::::|.::...|   |.....||.
  Rat   844 -WSLVVD-------PSFCSRQEKDVIKRQDVIFELMQTEVHHIQTLLIMSEVFRKGMKEELQLDH 900

  Fly  1611 SVLSAKDRKALFSYIVPVHECSERLL------------TELEACWQDN----IMLLG---LSRCI 1656
            |.:   ||         :..|.:.||            ...|:|..::    |..:|   :.:..
  Rat   901 STV---DR---------IFPCLDELLETHKHFFFSMKERRQESCTGNDRNFVINQIGDILVQQFS 953

  Fly  1657 YEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQH--------LERLEASPSCCGLNLHS 1713
            .|.|.:...:|..||.|........:.|:::|:   ||..        |.|....|.|
  Rat   954 EENASKMKRIYGDFCSHHKEAMSLFKELQQNKK---FQNFIKIRNSNLLARRRGIPEC------- 1008

  Fly  1714 FLMLPMQRITRLPLLIDAV--FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELER 1776
             ::|..||||:.|:|::.:  ::||   ..||:......|.|::.::...:...:.:|:..:...
  Rat  1009 -ILLVTQRITKYPVLVERILQYTKE---RTEEHRDLCRALGLIKDMIAAVDLKVSEYEKNQKWLE 1069

  Fly  1777 IARQLEFPSHVRALAIAPVGVPRAG---AKPRFLVKRGELTH---LLWRGEDAKLTFGKRLTKIS 1835
            |..::|..::.:.         :.|   .|...:.:...|.|   :.|:....:..        .
  Rat  1070 ILNKIENKTYTKL---------KNGHVFRKQALMSQERALLHDGLVYWKTATGRFK--------D 1117

  Fly  1836 IYAFLFSDLLLLCKRRGES-CFSVFDYCP-----------------RSMLTLAAGDSLPQLPTKD 1882
            |.|.|.:|:||..:.:.:. .|:..|..|                 |.|..::|..:.|::....
  Rat  1118 ILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIH 1182

  Fly  1883 LKDQAGKNLILMTLLENCDRKTVELVLSCP-------SVSDQQRWLQAMRPPEAETPGEKLYESW 1940
            ...:..:|        |..|:..:.|.|||       |.||::|     |..:|     ::.:..
  Rat  1183 TSSKEERN--------NWMRRIQQAVESCPEEEGGRTSESDEER-----RKADA-----RVAKIQ 1229

  Fly  1941 DCPQVVAKHSYE----SDEPDVLQLELGDV 1966
            .|.::::....:    .:|...:..|||::
  Rat  1230 QCQEILSNQDQQICTYLEEKLHIYAELGEL 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	45/213 (21%)
		PH_ephexin	1805..1931	CDD:269929	29/153 (19%)
		SH3_ephexin1_like	1944..1998	CDD:212727	4/27 (15%)
Arhgef28	XP_038958459.1	C1_p190RhoGEF	659..719	CDD:410426	14/61 (23%)
		RhoGEF	866..1055	CDD:214619	45/214 (21%)
		PH_p190RhoGEF	1100..1200	CDD:275430	19/115 (17%)
		DUF5401	<1368..>1536	CDD:375164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900