Protein Alignment Exn and Fgd3

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_008769765.1
• Gene: Fgd3 / 361223
• RGDID: 1311725
• Length: 733
• Species: Rattus norvegicus
• Alignment Length: 627
• Identity: 120/627 - (19%)
• Similarity: 223/627 - (35%)
• Gaps: 162/627 - (25%)

  Fly  1425 SPRGDEPVTP----TPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPH 1485
            ||.|.....|    .|.|..|.|:...:|.|.:.|| ::...:..||:.:.:.:...:....|..
  Rat    28 SPLGKLQALPFGSGAPQGAQGSSASAGDSSLGEPSG-AMKIPNRDSGIESPSSSVASENFPCEEG 91

  Fly  1486 SLFSNEP-LYQMYSAAKLES-ITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNG 1548
            |..|..| :..::....::| ..:|....|...|..|       .|:|.:.|       ..|:..
  Rat    92 SEGSPSPAILGLHPEVAVDSRAPQDNPQEGEDSGVGE-------DPDPKITP-------CRPEED 142

  Fly  1549 PSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVL 1613
            ...|..|:..:::|                ...|::.:|.:|:|.|:||.:.|.   |.|..:.:
  Rat   143 VGSTQCSDPQKLLH----------------IAQELLHTEEAYVKRLHLLDQVFC---AKLTEAGI 188

  Fly  1614 SAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYE----------IAERHFHVYV 1668
            ..:....:||.|..::.            :....:|.||.:.|.|          |.::......
  Rat   189 PPEVTTGIFSNISSIYR------------FHGQFLLPGLKKRITEEWDTKPRLGDILQKLAPFLK 241

  Fly  1669 AFCEHQGRMDRTLRRLKE-SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAV 1732
            .:.|:....||.:..:.. ::.|..|:..:..::....|..|.|...::.|:||:.|..||:..
  Rat   242 MYGEYVKNFDRAMGLVSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKD- 305

  Fly  1733 FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGV 1797
            :.|..|.:..:.:..:.:|.|:.......|.|..:.|:..:|..:..||.....:    :.|...
  Rat   306 YLKRLPRDAPDRKDAERSLELISIAADHSNAAIRKMEKMHKLLEVYEQLGGEEDI----VNPANE 366

  Fly  1798 PRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLC----KRRGESCFSV 1858
                     |:|.|.:..|          ..|..|....:.|||::::|.|    :..|:. |||
  Rat   367 ---------LIKEGNIQKL----------SAKNGTTQDRHLFLFNNVMLYCVPKLRLMGQK-FSV 411

  Fly  1859 FDYCPRSMLTLAAGDSLPQLPTKD-LKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQ 1922
                 |..:.::      .|..:| :|..|.:..|:      ..||. .|.|...:..:::.|:|
  Rat   412 -----REKMDIS------DLQVQDVVKPNAARTFII------TGRKR-SLELQTRTEEEKKEWIQ 458

  Fly  1923 AMRPPEAETPGEKLYESWDCPQVVAKHSYESD-----------------EPDVLQLELGDVVNVS 1970
            .::                  ..|.||..:|:                 .||...|..|.|.
  Rat   459 VIQ------------------ATVEKHKQKSETFRAFSGACTQEEEPSLSPDQPVLSAGPVE--- 502

  Fly  1971 RKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQR 2012
               |.|      :.|.: |..||..:.:|:|   :.|..|::
  Rat   503 ---PAG------VADSS-GGTPGIESRKLSS---KTRRDKEK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	37/192 (19%)
		PH_ephexin	1805..1931	CDD:269929	27/130 (21%)
		SH3_ephexin1_like	1944..1998	CDD:212727	15/70 (21%)
Fgd3	XP_008769765.1	RhoGEF	157..336	CDD:279015	37/194 (19%)
		PH-like	367..474	CDD:302622	31/153 (20%)
		PH	367..465	CDD:278594	27/144 (19%)
		FYVE_FGD3	527..580	CDD:277279	1/5 (20%)
		PH2_FGD1-4	606..710	CDD:270056
		PH	622..711	CDD:278594

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810