DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Y105E8A.25

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001300405.1	Gene:	Y105E8A.25 / 3564893	WormBaseID:	WBGene00013682	Length:	1619	Species:	Caenorhabditis elegans

Alignment Length:	1427	Identity:	250/1427 - (17%)
Similarity:	441/1427 - (30%)	Gaps:	466/1427 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 EKDDTLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVEVKPNNWLEG 818
            |:..:|.|.....|..|| |.|:.....|:                    |:|:...:.||
Worm     6 EEASSLPPLPSSPPPEPV-DPTRITFTLSN--------------------ESSSPRYEFNN---- 45

  Fly   819 YESIAGSQEACPLTYDGYES------------------FAPEEVVT--TPTTPSATGTLGRNTRD 863
               :..|......:|..|.|                  |..|..::  :||:|
Worm    46 ---LVTSSSPSYFSYQPYTSPGIYLLPDREQQPYFGADFQTESSISWNSPTSP------------ 95

  Fly   864 ELPELPKPKRVLNKSPI----PLRPAPPKPQAKESEEDENIYDTIKGCYESMH-----CKATSSS 919
                 |.|..::.:...    ..||..|:..|       |..|::..|.:..|     ..|.|:|
Worm    96 -----PPPPMIVEEEMRSGGGTARPVTPRSIA-------NSLDSLSECAQHHHHHSDVVNANSNS 148

  Fly   920 ----SSGEATLTT----DTISLSSNCYESISHIRRSRVATTQNQGHG----SAGSCIQLSSSGST 972
                |.|:....|    :..||.:..|:::        .||..:|.|    ..|..:.|......
Worm   149 DRSRSLGDLLAATMQDGNDDSLRNGSYDTL--------VTTTTKGGGLTDSGIGGGLLLMKGEDE 205

  Fly   973 LTISSDHKTNSLYE-----SSLAAAGCVVYGSASVGCRSSLGSSAG----SRDSGKPGDK--RSS 1026
            :.|..||.::|..:     :.:::.....|...|......:..|..    |.::..|.|.  |..
Worm   206 MDIMDDHNSSSSPDHHRIPTDISSPDSFTYPPVSFTSYDPVNGSGSVPSYSNENTNPLDSTPRGH 270

  Fly  1027 IAGSSDNSDAWVDISDGEIGQATTDATANEAQFI-VVRERFKPHRTR-SPDWSKRIRDKRLQQKK 1089
            .|....:||.          .|.::.:.:|.|.| :....:.||.:. .|..:..:|:.......
Worm   271 SADDRKHSDL----------PAISEESEHEQQSIHIPYNHYPPHSSSVGPGAAPAVREVVEHTYP 325

  Fly  1090 AISCIEDDSDHYYETLSPLGNKR-------HSTQLVRQSQDGNRSGGVRSSHRR---SKNHSASA 1144
            .:.|....|:..:.: ..:.::|       .:|:|.|..:..|.....|.|..:   |.||.:.:
Worm   326 MVHCNSAPSNTVFNS-DRIAHRRVVSDDVTETTRLKRSEELENMDKVGRISFEKRSASTNHLSKS 389

  Fly  1145 HTLGEHVVISDDYDSFETDS----DDHGDG----------EPDLRQRNYNDSGVDMR-------- 1187
            ......|..:|..:..|||.    :|..||          |....:..|..:.|..:
Worm   390 RKGATLVFHNDPNEKDETDDEEEYEDAADGYSKDNEMLILEKSGGEERYRMASVKKKNGSPLRHF 454

  Fly  1188 -NH--------------RLP------------------------KPPP----------PQ----- 1198
             ||              |||                        |.||          ||
Worm   455 DNHSNLTSISSTEPPPVRLPRRVSAVSSTSRSSPQRATDQSWKDKMPPFGIVGHSMYSPQSLPSR 519

  Fly  1199 ------------------NQVYEFVRKFKDFISSKKSPKGSQ---------QKLYENTPASTLFY 1236
                              :.:....|:|...::   ||.|.:         .:||||...|:...
Worm   520 DAIPRTPFDGSTISSGASSNIGGSQRQFSHEVT---SPDGDETPDSRYSTSSRLYENHSISSPTA 581

  Fly  1237 VECSKRTEDVYE----------------NTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLR 1285
            :..::.|:|:..                ||:......|..::.|      ||       |...:|
Worm   582 LLAAELTDDLMPLSEICKNHRLSISSSINTEHSQSPPPKSQSGG------AP-------NSSFVR 633

  Fly  1286 SRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGF---SDKNCTP 1347
            ..|||.:...|..|..|......|:        |||.        ..:..:.|.|   :.:...|
Worm   634 RSLRKIMKRGSVSTSALGGDEGLRN--------GSLK--------RRASNVSSSFFASAQERLRP 682

  Fly  1348 LPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAE 1412
            ..::.|...:.:.||||...:...|...|....||...|.:.      |...:||...||
Worm   683 RAKSLKKQRIGKNAKKEKSGSDTFTFGNLFRKKPPTSRPNLA------DIISDLDQRSTT----- 736

  Fly  1413 CGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSG-ISVASSSGSSGVSTGNEA-- 1474
                                    .|.||.|.....:....||. |...||:|....:|..::
Worm   737 ------------------------GGRGGGSLSAGATNRRSTSATILPMSSAGGCDPTTPFDSAC 777

  Fly  1475 ---GLGDEL------SSEPHSLFSNEPLYQMYSAAKLESITRDLE-AHGSSDGYEEIGLQAKAKP 1529
               ||.|.:      |..||...|:..|   ..|..:.|:...|: .:|..|.:.....|:
Worm   778 SLDGLPDHISRMVSPSDSPHHATSSSTL---NGANSMSSLYVQLDRIYGKHDLFANDEYQS---- 835

  Fly  1530 EPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSL 1594
                                    |.|  :..|:    ||::::...|:|.||:...|..:..::
Worm   836 ------------------------WHE--KYRHN----TLSTKQVKKQDAIFELYLMEKRHCANI 870

  Fly  1595 NLLRRHFMNHNAFLDSSVLSAKDRKALFSYIV-PVHECSERLLTELEACWQDNIMLLGLSRCIYE 1658
            ..|...:  ....||.::::.:|...|...:: |:......:|..:.|..::|..:..:|..|.|
Worm   871 AFLLHGY--RRRMLDENIITKQDMDVLIPDVLEPLLIFHLNVLERITARMKENYEVGTISDIISE 933

  Fly  1659 ----IAERHFHV----YVAFCEHQGRMDRTLRRL-----------KESKESLAFQQHLERLEASP 1704
                ...:|..:    |..|...:.|.|.....|           |::.....|.:|.:
Worm   934 ELAIDGGQHTKLCCDAYTDFGVAKERSDVLYHHLMNKNAKFAEFFKKTYSEETFYKHYD------ 992

  Fly  1705 SCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWE 1769
                  ....:...:.|.|:..||::.:...|.|.: |.::..|..|...:|...:.:...:...
Worm   993 ------FRPLITKIIGRATKYSLLLETILKNEQPFS-EYHDLTKTALETARKFAHKIDGNLSMAH 1050

  Fly  1770 QAFELERIARQLEFPSHVRALAIAPVGVPRA------------GAKPRFLVKRGEL--------- 1813
            .:.:.|.:..|:: .|....|.::...|..|            .|..|.||..||.
Worm  1051 MSMKWEELKAQID-SSSATTLYVSDPSVANATIRYTFDLDSLNSATNRKLVHLGEALIKIPVNPV 1114

  Fly  1814 -----THLLWRGEDAKLTFGKRL-TKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAG 1872
                 ||        ..:.||:: .|...|..||.|::::..|:..          |.::.:...
Worm  1115 GSGGGTH--------SSSSGKQVDKKDQCYIVLFDDIIVILIRKSS----------RQLIFMQDQ 1161

  Fly  1873 DSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR------PPE 1928
            ..:|...........|.:::|::     ..|.|...:|..:.:|:::|:..:.      |||
Worm  1162 GVMPVQSLLIRTAARGHSIMLIS-----GAKPVLFEISFHTSTDRKKWVTLLELAPKNVPPE 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	34/201 (17%)
		PH_ephexin	1805..1931	CDD:269929	27/145 (19%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Y105E8A.25	NP_001300405.1	RhoGEF	852..1043	CDD:238091	36/205 (18%)
		PH_16	1095..1211	CDD:375371	24/138 (17%)
		OmpH	<1540..>1591	CDD:214922
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900