Protein Alignment Exn and cyst

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001260588.1
• Gene: cyst / 35237
• FlyBaseID: FBgn0032796
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 1126
• Identity: 212/1126 - (18%)
• Similarity: 343/1126 - (30%)
• Gaps: 444/1126 - (39%)

  Fly   868 LPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDTIS 932
            :|.|.|.      |:.|.|....|..:..:.|:..||.   .:.|..|.:|..:   .:..||:|
  Fly    54 VPGPARA------PIAPPPASNPASNTINNNNMIPTIN---VTPHSPALASKYN---NIFEDTLS 106

  Fly   933 LSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVY 997
            ...|..|::                      :|:.:|.|    .|.|    :.:.|||..|.:..
  Fly   107 QLQNIRETV----------------------VQMKNSSS----PSQH----MQDGSLANHGLLSA 141

  Fly   998 GSASVGCRSSLGSSAGSRDSGKPGDKRSSIAGS------SDNSDAWVDISDGEIGQATTDATANE 1056
            ...|.......|:..|....|......||.|..      :|...:|..:.|   |....|.|
  Fly   142 AILSTSLPDLTGTGTGPASGGSNYAMWSSTAPQQCQFLHTDRRKSWTAVDD---GSGAGDCT--- 200

  Fly  1057 AQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQS 1121
                                           .|::|....||:. .||:.....:|.|.:
  Fly   201 -------------------------------NKSVSLSSLDSEE-QETIRVTEQRRRSAR----- 228

  Fly  1122 QDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGVDM 1186
               |.:||:            |.|:|.|
  Fly   229 ---NSTGGI------------STHSLNE------------------------------------- 241

  Fly  1187 RNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTD 1251
                           .|..|.| :.|::|:                       |..||.:
  Fly   242 ---------------AELARDF-ERIAAKR-----------------------SLATEII----- 262

  Fly  1252 FGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQ-LSSLAPTRSTFYVE 1315
               .|||                             |:||:..||...|: :.::|  |.....|
  Fly   263 ---SRIP-----------------------------LQKSISTSSIIAKEDIKAIA--RHLTDSE 293

  Fly  1316 DPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTV-ARKAKKEAKANRRRTTIGLRPN 1379
            |...||.....:.|::.:.|              :.||..:: .||.|.:||.   ::.:|
  Fly   294 DENQSLLRAHAKIEVYDTVE--------------KRPKRGSIFFRKKKPKAKT---KSLVG---- 337

  Fly  1380 DPPPPPPPMTGNKSPLDP-ERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVS 1443
                      |..|..|. ...:...|....:.||.|.|.                     ||..
  Fly   338 ----------GQLSACDVCGAAITLAQIKEHHLECKVKKM---------------------GGGQ 371

  Fly  1444 SWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSN---EPL----YQMYSAAK 1501
            .:|                       .|.:|           |.|||   :||    .|..:.|.
  Fly   372 DYY-----------------------DGPDA-----------STFSNPEDQPLIRSDLQFLNEAP 402

  Fly  1502 LESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCIL 1566
            :|:  :||.|                  :|::     .:.|.|..:      |:  |.|... :|
  Fly   403 IEA--QDLGA------------------DPVL-----GIVLKEHDS------WT--PNVPRE-LL 433

  Fly  1567 PTLTSRERSLQEAKFEIITSEASYLKSL--------NLLRRHF--MNHNAFLDSSVLSAKDRKAL 1621
            .||...:...||..:|.|.:|..:.::|        ..|.|||  :|.|:....
  Fly   434 KTLKDLQIKRQEHIYEFIMTEKHHCQTLIVMQKVFVESLERHFPSLNLNSMFPR----------- 487

  Fly  1622 FSYIVPVHECSER--LLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFC-EHQGRMDRTLRR 1683
            ...:..:|.|..|  .|.:.|....|:|..:.|.....|.|:.....|..|| .|:..:|:.  :
  Fly   488 LQQLTDLHTCFLRQLRLKQREQHMVDSIADILLDFFSLEQAQCLRLAYGEFCANHRSALDQF--K 550

  Fly  1684 LKESKESLA------FQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNRE 1742
            |..::.|.|      .|..|.:.:..|.|        ::...||:|:.||||:.:. |.:..|:.
  Fly   551 LCLTEPSFAEWYKHCLQNPLLKKKGIPEC--------ILFVTQRLTKYPLLIEPLL-KSARDNKL 606

  Fly  1743 EYESWKLTLALVQKV---VGQCNEAANRWEQAFELERIARQLEFPSHVRALAIA-----PVGVPR 1799
            |.:..:..|.||:.:   |..|         ..|.|...||||....|.|.:.|     |.....
  Fly   607 ETDKLQHALNLVKSLLVDVDAC---------VAEKELRERQLEIYGRVDAKSFAIYKNKPFRKTE 662

  Fly  1800 AGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPR 1864
            .|.:.|..:|...|         |.|..|:..|::.:...|...|..|.:..|.:.:|.|
  Fly   663 LGVESRRRLKFDGL---------ATLMQGRAKTQLVLVVVLTDCLCFLSENSGHNKYSFF----- 713

  Fly  1865 SMLTLAAGDSLPQ-----LPTKDL--KDQAG-KNLILMTLLENCD-RKTVELVLSCPSVSDQQRW 1920
                      .|:     :|.:.|  :::|| ::..:..:..|.| .:..||.:..|  .|:..|
  Fly   714 ----------TPEHKAGVVPLQKLLIREKAGTESRGIYIISSNPDFPEMYELKVQTP--KDKNTW 766

  Fly  1921 LQAMRPPEAETPGEKLYESWD 1941
            :|.:|....:.|...:.|:.|
  Fly   767 IQTIRQAVLDCPATDIIEAED 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	47/203 (23%)
		PH_ephexin	1805..1931	CDD:269929	27/134 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727
cyst	NP_001260588.1	RhoGEF	447..627	CDD:279015	46/201 (23%)
		PH_ARHGEF2_18_like	671..774	CDD:275432	26/128 (20%)
		PH	681..774	CDD:278594	22/109 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810