DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exn and Arhgef26

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:XP_227201.4 Gene:Arhgef26 / 310460 RGDID:1562559 Length:869 Species:Rattus norvegicus


Alignment Length:961 Identity:264/961 - (27%)
Similarity:420/961 - (43%) Gaps:212/961 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1169 DGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPAST 1233
            |||.::   :::.:||.....|...||      .:.:.:      ||..|:..|      :|:..
  Rat     2 DGESEV---DFSSNGVTPLWRRRSTPP------LQLLGR------SKPRPQSYQ------SPSGL 45

  Fly  1234 LFYVECSKRTEDVYENTDFGPER---IPAPETKGPV--HQEQAPVLRAKQ---------KNGKSL 1284
            |.              |||..|.   :|||:|..||  ..|...|.|:.|         .||:::
  Rat    46 LI--------------TDFPVEELAALPAPQTPVPVPAGPEGRTVSRSPQLLCAHRRPVTNGRTV 96

  Fly  1285 -------RSRLRK------SLVGSSFDTKQ-----LSSLAP--TRSTFYVEDPEGSLP------- 1322
                   ..|||:      |...|....|.     :||.|.  :|::...:.|..|.|       
  Rat    97 SPDYRAASPRLRRPKSPLVSYAASGGSPKSAVNGTVSSPAALLSRASRTPDIPASSAPGEDRTRV 161

  Fly  1323 ---------ALPLEPEIHGSGEL-DSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLR 1377
                     |..|.|:...||.: .:|.|..:..|.|.  :.|...:....|.|...:|  :..:
  Rat   162 TASKVSSPTANGLAPKTDSSGPVSQTGQSAGDLEPSPS--RLSPAPQHRSSEQKLPLQR--LPSQ 222

  Fly  1378 PNDPPPP--------PPPMTGNKSPLDPE---RELDAEQTTSWYAE-------CGVFKQATNGAV 1424
            .|:.|.|        |..:...|..:.|:   .|:...::.|...|       .....:.....:
  Rat   223 GNELPNPSVILSTNSPAALKMGKQQIIPKSLASEIKLSKSNSQNVEPHRRLLKVRSMVEGLGAPL 287

  Fly  1425 SPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFS 1489
            .|.|:|..........|.......|..|:.:.:|                  |.:..|...|...
  Rat   288 GPEGEESEADNDIDSPGSLRRGLRSTSYRRAVVS------------------GFDFDSPTSSKKK 334

  Fly  1490 N---EPLYQ--MYSAAKLESITR----DLEAHGSSDG---------YEE--IGLQAKAKPEPLVK 1534
            |   :|:.:  |....|..|:.|    .|:..|:.||         |:|  :.:.:..:||| .:
  Rat   335 NRMSQPVLKAVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEEPEP-KE 398

  Fly  1535 PRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRR 1599
            .:|....::..|  |.|:.||::..|..:.:..|::..||..|||.||:|:||.|||.||.:|.|
  Rat   399 QKPEEKIVIHHK--PLRSTWSQLSAVKRNGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIR 461

  Fly  1600 HFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERH- 1663
            .|.:.....|:  ::..:|..|||.|..|.|.|::..|||||..|:||.:..:|    :|.|:| 
  Rat   462 MFKDSKELTDT--MTKTERHHLFSNITDVWEASKKFFTELEARHQNNIFIEDIS----DIVEKHT 520

  Fly  1664 ---FHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRL 1725
               |..||.:|.::....|||::|..:..|  |::.|.|:|:...|..|.:.|||:|||||:|||
  Rat   521 ASTFDPYVKYCTNEVYQQRTLQKLLTTNPS--FKEVLSRIESHEDCRNLPMISFLILPMQRVTRL 583

  Fly  1726 PLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRAL 1790
            |||:|.:..| :|.:..:||..|..|..|.|:|..|||.|.:.|:...:..|..||||       
  Rat   584 PLLMDTICQK-TPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEF------- 640

  Fly  1791 AIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESC 1855
            .|.|..:.   :..|:||||||||..:   ||..| |.||::|..:|.|||:|:|::.|::.|..
  Rat   641 KIKPFPLV---SSSRWLVKRGELTAYV---EDTVL-FSKRMSKQQVYFFLFNDVLIITKKKSEES 698

  Fly  1856 FSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKN--------------LILMTLLENCDRKTVE 1906
            ::|.||..|..|.:.:.|:      ::|....|||              |..:|:|.|...:.|:
  Rat   699 YNVNDYSLRDQLLVESCDN------EELNSSPGKNTSTMLYSRQSSATHLFTLTVLSNHANEKVD 757

  Fly  1907 LVLSCPSVSDQQRWLQAM------RPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGD 1965
            ::|...:.|::.||:.|:      :||:..|          ..||....|:.:.:||.|.|::.|
  Rat   758 MLLGAETQSERARWITALGHSSGKQPPDRTT----------LTQVEITRSFTAKQPDELSLQVAD 812

  Fly  1966 VVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRLL 2016
            ||.:.:::.||||:|||:|||..||||....:|:.......:|:::..|||
  Rat   813 VVLIYQRVGDGWYEGERLRDGERGWFPMECAKEITCQATIDKNVERMGRLL 863

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 74/185 (40%)
PH_ephexin 1805..1931 CDD:269929 46/145 (32%)
SH3_ephexin1_like 1944..1998 CDD:212727 24/53 (45%)
Arhgef26XP_227201.4 TDA11 140..>348 CDD:293689 39/229 (17%)
RhoGEF 441..620 CDD:279015 75/187 (40%)
PH_ephexin 641..779 CDD:269929 46/150 (31%)
SH3_ARHGEF16_26 791..845 CDD:212871 24/53 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 116 1.000 Domainoid score I5800
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45587
orthoMCL 1 0.900 - - OOG6_105893
Panther 1 1.100 - - O PTHR12845
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.810

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