Protein Alignment Exn and Fgd2

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_038954639.1
• Gene: Fgd2 / 309653
• RGDID: 1309840
• Length: 707
• Species: Rattus norvegicus
• Alignment Length: 595
• Identity: 122/595 - (20%)
• Similarity: 204/595 - (34%)
• Gaps: 155/595 - (26%)

  Fly  1415 VFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGI-----------SVASSSGSSGV 1468
            ||:.:.....|  |.|.:.|...| ..:.|:|:..|.....|:           ...|:.||.|.
  Rat    17 VFENSRASFTS--GVEQLDPASPG-AWLDSFYSAPGTALGHGLPWTTTPDVGDHHTQSAGGSPGA 78

  Fly  1469 STGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLV 1533
            :.|            ||| |.::|                   |....       |....|||..
  Rat    79 APG------------PHS-FEDQP-------------------HSPEH-------QLPLSPEPWE 104

  Fly  1534 KP----------RPTA-LQLVEPKNGPSRTLWSEIPEVIHSC---ILPTLTSRERSLQEAKFEII 1584
            .|          ||.: ..|...||..|...|.:      ||   ..|...::|...:....|::
  Rat   105 APPAGEALTSEFRPVSRTYLNSLKNKLSSGAWRK------SCQPGASPGPETQEPEEKRVVQELL 163

  Fly  1585 TSEASYLKSLNLLRRHFMNH--------NAFLDSSVLSAKDRKALFSYIVPVHEC-SERLLTELE 1640
            .:|.:|:..|:||.:.|...        .||.:..|      |.:||.|..::.. ::..|.||:
  Rat   164 ETEQAYVARLHLLDQVFFQELLREASRSKAFPEDVV------KLIFSNISSIYRFHAQFFLPELQ 222

  Fly  1641 ACWQDNIMLLGLSRCIYEIAE--RHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEAS 1703
            ....|......:...|.::|.  :.:..||...|....:..|.     ..:|..||:.:.|::.|
  Rat   223 RRVDDWTATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATW-----MDKSQPFQEVVTRIQRS 282

  Fly  1704 PSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRW 1768
            .:...|.|...::.|:|||.|..||:.. :.::.|....:.|..:..|.::.......|.|....
  Rat   283 EASGSLTLQHHMLEPVQRIPRYELLLKE-YVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEM 346

  Fly  1769 EQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTK 1833
            |:...|..:.::|.....:    :.|...                  ||..|...|::| :|...
  Rat   347 ERLQGLWDVYQRLGLEDDI----VDPSNT------------------LLREGPVLKISF-RRSDP 388

  Fly  1834 ISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMT--- 1895
            :..|..||:::||              ||...:|.:.|     |...:...|.||..:..:|
  Rat   389 MERYLVLFNNMLL--------------YCVPRVLQVGA-----QFQVRTRIDVAGMKVRELTDAE 434

  Fly  1896 ----LLENCDRKTVELVLSCPSVSDQQRWLQAMRP--PEAETPGEKLYESWDCPQVVAKHSYESD 1954
                .|.:..::|:|  |...|..:...|:||.:.  .:.|...|....:...||      .::.
  Rat   435 FPHSFLVSGKQRTLE--LQARSREEMVSWIQACQAAIDQVEKRSETFKAAVQGPQ------GDTQ 491

  Fly  1955 EPDVLQLELG 1964
            ||.....|||
  Rat   492 EPKPQAEELG 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	41/192 (21%)
		PH_ephexin	1805..1931	CDD:269929	28/134 (21%)
		SH3_ephexin1_like	1944..1998	CDD:212727	6/21 (29%)
Fgd2	XP_038954639.1	RhoGEF	156..340	CDD:238091	41/195 (21%)
		PH1_FGD2	372..479	CDD:275421	30/128 (23%)
		FYVE_FGD1_2_4	505..569	CDD:277280
		PH2_FGD1-4	591..692	CDD:270056

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810