DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Fgd3

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_056574.2	Gene:	Fgd3 / 30938	MGIID:	1353657	Length:	733	Species:	Mus musculus

Alignment Length:	601	Identity:	112/601 - (18%)
Similarity:	202/601 - (33%)	Gaps:	171/601 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1392 KSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPT-PSGHGGVSSWYAESGLYQT- 1454
            :||..|:.|.        .:..||.  .|..:.||.|.....|. |..|.|..|..|.:|...|
Mouse     5 RSPSTPQEEA--------ISPLGVL--GTGPSSSPLGKLQALPIGPGAHRGAHSSSAPAGDSSTR 59

  Fly  1455 ------------SGISVASSS----------GSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMY 1497
                        |||...|||          .|.|..:....||..|.:|:
Mouse    60 EPSGAMKIPNRDSGIDSPSSSVASENFPCEESSEGSPSPAILGLPSETASD-------------- 110

  Fly  1498 SAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIH 1562
                 ..:.:|........|..|       :|:|.|       .|..|:...|.|..|:..:::|
Mouse   111 -----SRVPQDNPQEEEDSGMGE-------EPDPKV-------TLFRPQEDVSLTQCSDPQKLLH 156

  Fly  1563 SCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVP 1627
                            ...|::.:|.:|:|.|:||.:.|...   |..:.:..:....:||.|..
Mouse   157 ----------------IAQELLHTEEAYVKRLHLLDQVFCTK---LTEAGIPLEVTTGIFSNISS 202

  Fly  1628 VH---------ECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRR 1683
            ::         |..:|:..|    |..|..|       .:|.::.......:.|:....||.:..
Mouse   203 IYRFHGQFLLPELQKRITEE----WDTNPRL-------GDILQKLAPFLKMYGEYVKNFDRAMGL 256

  Fly  1684 LKE-SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESW 1747
            :.. ::.|..|:..:..::....|..|.|...::.|:||:.|..||:.. :.|..|.:..:.:..
Mouse   257 VSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKD-YLKRLPRDAPDRKDA 320

  Fly  1748 KLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGE 1812
            :.:|.|:.......|.|..:.|:..:|..:..||.....:    :.|...         |:|.|.
Mouse   321 ERSLELISTAADHSNAAIRKMEKMHKLLEVYEQLGGEEDI----VNPANE---------LIKEGS 372

  Fly  1813 LTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQ 1877
            :..|          ..|..|....:.|||::::|.|             .|:..|   .|..|..
Mouse   373 IQKL----------SAKNGTTQDRHLFLFNNVMLYC-------------VPKLRL---MGQKLSV 411

  Fly  1878 LPTKDLKDQAGKNLI----LMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYE 1938
            ....|:.|...::::    ..|.:....::::|  |...:..:::.|:|.::
Mouse   412 REKMDISDLQVQDIVKPNAACTFIITGRKRSLE--LQTRTEEEKKEWIQVIQ------------- 461

  Fly  1939 SWDCPQVVAKHSYESD 1954
                 ..|.||..:|:
Mouse   462 -----ATVEKHKQKSE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	37/191 (19%)
		PH_ephexin	1805..1931	CDD:269929	22/129 (17%)
		SH3_ephexin1_like	1944..1998	CDD:212727	4/11 (36%)
Fgd3	NP_056574.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		35/164 (21%)
		RhoGEF	156..335	CDD:238091	38/209 (18%)
		PH-like	367..474	CDD:418428	26/152 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..535
		FYVE_FGD3	527..580	CDD:277279
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..612
		PH2_FGD1-4	606..710	CDD:270056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810