DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and Akap13

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:XP_038961459.1 Gene:Akap13 / 293024 RGDID:727893 Length:2793 Species:Rattus norvegicus


Alignment Length:2352 Identity:435/2352 - (18%)
Similarity:763/2352 - (32%) Gaps:755/2352 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 VNSDSENNNRATCDKAGKDNPNPNQ--NPNS-----QANPNQNC----------------SCESR 99
            ::|..|..|.....|..||...|.:  .|.|     .|:...:|                ||.:|
  Rat   345 LSSVVEEENLICSHKKNKDTGRPGEGVEPASAVDSRSASHQDSCLQSIPDCGVKGREGLPSCGNR 409

  Fly   100 ---AFRDFRGVQTLRLLWSRRIKSASEDQCHSPVHCHTS--SSSLGTLKKLNKSVSCLVNAFNNS 159
               ....:.||.|                |..|:...:|  ...|.|.....:..|......::|
  Rat   410 NEVTGTQYSGVAT----------------CQQPLSSESSVPQDVLVTEPDARQHSSGRELPDSSS 458

  Fly   160 RDCATPEKTLAKRAASL-HNL-------QDSQAKHKQLHREKDNFYKYKNAEQAKMQA------- 209
            .|...|||     |..| |:|       |:|:.:..:..:|:.......:||...:||       
  Rat   459 TDAGAPEK-----AGELEHSLLTPDATTQNSKPQVGESAKERLENSDISSAEATAVQALREPKQK 518

  Fly   210 --------KLRSSADEAILNASETRAKRD-----------DSGCLPGVKS-YNSKALSAADKVA- 253
                    ..|::..:|...||...:..:           :.||..|:.| .:|:.|.||.... 
  Rat   519 ADVTNHVFAARAAGADAPAEASPAWSPEEIPTGKPGMETQERGCEGGITSDQSSQVLPAAAAATE 583

  Fly   254 -KVAKG-EAKTQRRAEEPVGEAEVEVEVEFRAKREHNRLEGL-----SLSAASAQSGGSSESLQT 311
             ||..| |.:|.     |....|....::......  |.:|:     ..||..|||..|...| .
  Rat   584 NKVLDGLELETL-----PACPCETASSLDLTVSGP--RPDGMPKQNSESSAQHAQSLNSQAPL-C 640

  Fly   312 TTTSSSTPTTHSSVTSSTGRSGGRRKYSFKTHAGKSYHQHHHPSRRTSNMDSSNGGISMVAKLTH 376
            :...:.||:..|:...||           :|.:|.|..:  |.|...|..:|:..........|.
  Rat   641 SIAGAGTPSAESACPQST-----------ETSSGGSVIE--HGSGEASLPESTAAQPEPQGLCTA 692

  Fly   377 QFNEIIQKDAKLLEQVKRNNGVWISRGT-HVYKIVEKPTSEGKGLPNADDNRISTVQRNIKKFER 440
            ...|..|.|....:....|..   |.|: |:..:..|             |:...::::......
  Rat   693 PCPEDPQADTVTSDTAAHNQK---SVGSCHLCALDAK-------------NQEKDLRQDTPSVNT 741

  Fly   441 LEK----PSVPLKSEQLMRKHLELMRGSSLSRGPRIKRNLKLPPGSVGIPE---LAIVSEELKTP 498
            ||.    |||..:||:.:.......||||.|        |...|.|..:.:   |::||.:.:..
  Rat   742 LEDVPHLPSVVPQSEEKLEPDQVSPRGSSFS--------LASSPESESVTKDDVLSLVSSQKEKG 798

  Fly   499 TSEEQAKK----------------------------PKSVQNESQPNH----------------- 518
            |:..|..:                            |.:|:.::...:                 
  Rat   799 TATPQLHRAPACSDGPDGRDLNDTDKVGDGAASPPTPSAVELQTSMGNTSPVGVGEQEGSSLTAT 863

  Fly   519 ----PEELNQSNDKPSDELDLIMGEEG-------------------------------DEEELRQ 548
                .:.|.||.||.:...|.::.|||                               ..|..|:
  Rat   864 LEVLSDSLLQSVDKAALVSDSLLPEEGGSIVVPESSTALGQGGKDKATKCPSVKEDVHSSEMSRE 928

  Fly   549 KQRK----HKYASIYEKLRFTFAKGRK----SASPSPTKAQIREEVSIDEE-------SIKDSTS 598
            .||.    .:.:.:.||.......|.|    |.||....|.::.|...::|       .:|....
  Rat   929 DQRTPPPGQEISRLCEKPMSALCAGEKALQHSNSPDTPSACLQTETKHNKEVAPQSSPLMKGGAV 993

  Fly   599 EDMVTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEA----DAKILDALEAVDLKLKV---- 655
            :::|..|...:.|..:    :....|.|..:||.....||    ...:..::|::..:.|.    
  Rat   994 QNLVPPKTSLSADSEQ----KTSSTEQSGSSLLPGGASEALRCSQPSLSVSVESIQFQGKTSACK 1054

  Fly   656 --LNPLNDVTTADGERELLLAANDDFEQRILPNSSFVYQAANKQYSNN----QILLNQAVNVTLV 714
              .|.:.|||.||.    .||..:..::..|.:...:....|::....    :.||::.|.    
  Rat  1055 VSRNAMEDVTVADA----FLATAEPTKEDALHHVKDISDLLNQEKKTTPGLPEALLDKGVT---- 1111

  Fly   715 NAIEGEQMIMEQKQLMKVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYEP------------ 767
               :.:::|..:.:.:..:..:|...|:..|..:::::|..::|.:|.:...|            
  Rat  1112 ---DLQEVITPEIEPLDCKREKLEGTDLSCPTSKSKETPNNEETTQPPARDLPTETGLSAINDNG 1173

  Fly   768 -------------------ITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVEVKPN 813
                               :|.|:....|:|...      ...::.:|:....:.||...::|.:
  Rat  1174 PQADMKHVTQASVPGEESNVTTVLGMVSTQAADG------PPGADSIEETATRIVEAVIKQIKAS 1232

  Fly   814 NWLEGYESI----AGSQEACPLTYDGYES---FAPEEVVTTPTTPSATGTLGRNTRDELPELPKP 871
            |.|.....|    ..|.|...:...|.||   |.|.|.:....|...|      |.....|...|
  Rat  1233 NTLRTQVEIQNPPLSSSEIKEIENTGSESARVFLPGEPLQMENTQKET------TGHCSVETEAP 1291

  Fly   872 KRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLTTDTISLSSN 936
            ::::.....| .|||..|..|                           :.||..|.:        
  Rat  1292 EKIILAVHRP-EPAPEMPDTK---------------------------TGGEVDLLS-------- 1320

  Fly   937 CYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGC-----VV 996
                      .|.|.::.:..|:..:..::..:..|..|:.        ||..|...|     ::
  Rat  1321 ----------KRSAASEEEAIGNGAATPKMKQAPGTQVINR--------ESWCAIEPCPEAASLL 1367

  Fly   997 YGSASVGCRSSLGSSAGS----------RDSG-------KPGDKRSSIAGSSDNSDAWVDISDGE 1044
            ....|..|||.:....|:          |:||       .|.|:..||..|....:..:..:.| 
  Rat  1368 ASKQSSECRSFIDVGLGTECATKEGVLQRESGSDSDLFHSPSDEMDSIIFSKPEEEQLLCDTTG- 1431

  Fly  1045 IGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLG 1109
             ..::||.||:       .:|...|                           .||......|.|.
  Rat  1432 -SSSSTDDTAS-------LDRHSSH---------------------------GSDVSLPQTSKLN 1461

  Fly  1110 NKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDS--------------- 1159
            ..|:     .||.:|..|.||....|..::..|.:..:.|     ::.||               
  Rat  1462 RSRN-----HQSSNGFFSHGVDPESREGESEPAGSGEMEE-----EEMDSITEVPANRSFLRNSM 1516

  Fly  1160 -----FETDSDDHGD---GEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSKK 1216
                 |...|...|.   .:.::.||    |.:.:..|.:.:||..:.             |...
  Rat  1517 RSLSPFRRHSWGPGKNAASDAEMNQR----SSMQVLGHVVRRPPIHRR-------------SMSW 1564

  Fly  1217 SPKGSQQKL---------------------YENTPASTLFYVECSKRTEDVYENTDFGPERIPAP 1260
            .|.|.|...                     ..|.|:|:|   |.|........|...|.|:..:.
  Rat  1565 CPSGVQYSAALNADFNIRSFSLEGLTGGGGVGNKPSSSL---EISSANSSELRNPFSGEEQRSSL 1626

  Fly  1261 ETKGPVHQE-----------QAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSS-LAPTRSTFY 1313
            .:....|.|           |....|:||:              |.::.|..:|| |..:.|...
  Rat  1627 MSLSEEHLEPDQRQHHRMFDQQTCYRSKQQ--------------GFNYCTSAISSPLTKSISLMT 1677

  Fly  1314 VEDP--EGSLPALPLEPEIH-GSGELDSGFSDKNCTPLPETPK---------------FSTV--- 1357
            :..|  :.|.|       .| .|..|....:::||..||.:|.               ||.:   
  Rat  1678 ISHPGLDNSRP-------FHSASANLTESITEENCNFLPPSPSKKSFEEKSGTKVSRTFSYIRNK 1735

  Fly  1358 ---ARKAK-------------KEAKANRR-RTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQ 1405
               ::|:|             ||:|...: :.|:......|.|...|:..::. :.|....||..
  Rat  1736 MSSSKKSKEKEKEKDKTKEKEKESKEKEKDKKTLNGHTFSPIPIVGPINCSQC-MKPFTNKDAYT 1799

  Fly  1406 TTSWYAECGVF--KQATNGAVS--------PRG-----DEPVTPT---------PSGHGGVSSWY 1446
            .    |.||.|  |.......|        |:|     |....||         |......:...
  Rat  1800 C----ASCGAFVHKGCRENLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKSSQPKERPRSAVLL 1860

  Fly  1447 AESGLYQ---TSGISVASSSGSSGVSTGNEAGLG-DELSSEPHSLFSNEPLYQMYSAAKLESITR 1507
            ||..:..   |:..|..|.|.|..||..|..|:| ||..|......|:          ..:|:.:
  Rat  1861 AEEAIAAPMFTNRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH----------STDSLNK 1915

  Fly  1508 DLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSR 1572
            ..:.:.|::...:.|:........|:....:..:.:|.::. |||:.|:.           |..:
  Rat  1916 ICKVNESTESLTDEGVGTDMNEGQLMGDFESDSKQLEAESW-SRTVDSKF-----------LKQQ 1968

  Fly  1573 ERSL---QEAKFEIITSEASYLKSLNLL----RRHFMNHNAFLDSSVLSAKDRKALF---SYIVP 1627
            ::.:   ||..:|::.:|..::::|.::    .|..|....|....|      :.||   ..::.
  Rat  1969 KKDVVKRQEVIYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMV------EKLFPCLDELIS 2027

  Fly  1628 VH-ECSERLLTELEACWQDN------IMLLG---LSRCIYEIAERHFHVYVAFCEHQGRMDRTLR 1682
            :| :..:|:|...:....|.      |..:|   :|:...|.|||....|..||   |:.::::.
  Rat  2028 IHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVSQFSGENAERLKKTYGKFC---GQHNQSVN 2089

  Fly  1683 RLKE--SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVF--SKESPLNREE 1743
            ..|:  :|:. .||..:::..:|.....|.:...::|..||||:.|:|...:.  :|:   |..|
  Rat  2090 YFKDLYTKDK-RFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKD---NEVE 2150

  Fly  1744 YESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLV 1808
            .|....:|:||:.|:|..:.....:|:...|..|..:.:..|.:|                   :
  Rat  2151 QEDLTQSLSLVKDVIGAVDSKVASYEKKVRLGEIYTKTDSKSIMR-------------------M 2196

  Fly  1809 KRGELTHLLWRGEDAKLTFGKRLTK-------------ISIYAFLFSDLLLLCKRRGES-CFSVF 1859
            |.|:    ::..||.:   .|:|.:             ..:.|.|.:|:|:..:.:.:. .|:..
  Rat  2197 KSGQ----MFAKEDLR---RKKLVRDGSVFLKSATGRLKEVQAVLLTDILVFLQEKDQKYVFASL 2254

  Fly  1860 DYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAM 1924
            |:  :|.:.     ||.:|..:::..:. |.|.|:::... |.:.||:..|  |..::..|:|.:
  Rat  2255 DH--KSTVI-----SLKKLIVREVAHEE-KGLFLISMGVK-DPEMVEVHAS--SREERNSWIQII 2308

  Fly  1925 R--------------PPEAE-------TPGEKLYESWDCPQVVAKHSYESDEPDVLQLE-----L 1963
            :              |.|.|       |...:|.|...          :.|:..:|.||     .
  Rat  2309 QDTINSLNRDEDEGIPSENEEEKRLLDTKARELKEQLQ----------QKDQQILLLLEEKEMIF 2363

  Fly  1964 GDVVNVSRKLPD 1975
            .|:...|..||:
  Rat  2364 RDMTECSTPLPE 2375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 46/202 (23%)
PH_ephexin 1805..1931 CDD:269929 29/160 (18%)
SH3_ephexin1_like 1944..1998 CDD:212727 8/37 (22%)
Akap13XP_038961459.1 PHA03307 545..>837 CDD:223039 67/336 (20%)
C1_AKAP13 1769..1824 CDD:410428 12/59 (20%)
RhoGEF 1975..2169 CDD:238091 48/206 (23%)
PH_AKAP13 2212..2314 CDD:275427 21/112 (19%)
SMC_prok_B <2509..>2669 CDD:274008
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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