Protein Alignment Exn and Arhgef3

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_006252636.1
• Gene: Arhgef3 / 290541
• RGDID: 1310672
• Length: 551
• Species: Rattus norvegicus
• Alignment Length: 558
• Identity: 117/558 - (20%)
• Similarity: 207/558 - (37%)
• Gaps: 160/558 - (28%)

  Fly  1482 SEPHSLFSN---EPLYQMYSAAK---------LESITRDLEAHGSSDGYEEIGLQAKAKPEPLVK 1534
            |||    ||   :||.::.|.|.         |:..::.|:        ..|..:.:::|: ::.
  Rat    58 SEP----SNKRVKPLSRVTSLANLIPPVKTTPLKRFSQTLQ--------RSISFRNESRPD-ILA 109

  Fly  1535 PRPTALQLVEPKNGPSRT-------LWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLK 1592
            ||..:      :|..|.:       ||||..:|   |:...||::|...|||.||:...|...::
  Rat   110 PRAWS------RNATSSSTKRRDSKLWSETFDV---CVSQVLTAKEIKRQEAIFELSQGEEDLIE 165

  Fly  1593 SLNLLRRHFMNHNAFLDSSVLSAKDRKALF---SYIVPVHECSERLLTELEACWQDN-------I 1647
            .|.|.::.:  |:..|..|:::.::...:|   ..::|:|   |.||::|....:.:       .
  Rat   166 DLKLAKKAY--HDPMLKLSIMTEQELNQIFGTLDSLIPLH---EDLLSQLRDVRKPDGSTEHVGP 225

  Fly  1648 MLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLH 1712
            :|:|...|:..        |.::|.:|......   |...|:....|..|:|...||....|:|.
  Rat   226 ILVGWLPCLSS--------YDSYCSNQVAAKAL---LDHKKQDHRVQDFLQRCLESPFSRKLDLW 279

  Fly  1713 SFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERI 1777
            :||.:|..|:.:.|||:..:. :.:|.:..:.:..:..:.::|.:|.:.|......|..:..||:
  Rat   280 NFLDIPRSRLVKYPLLLREIL-RHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERL 343

  Fly  1778 ARQLEFPSHVRALAIAPVGVPRAGAK------PRFLVKRGELTHLLWRGEDAKLTFGKRLTKISI 1836
            ....|                  |.|      .|.|...|||               |....:.:
  Rat   344 LYLEE------------------GQKDSLIDSSRVLCCHGEL---------------KNNRGVKL 375

  Fly  1837 YAFLFSDLLLLCK---RRGESCFSVF-DYCPRSMLTL--------AAGDSL-------------- 1875
            :.|||.::|::.:   ...:.|:.:: ...|...|||        ..|.||
  Rat   376 HVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFF 440

  Fly  1876 -------PQLPTKDLK--DQAGKNLILMTLLENCDRKTVELVLSC---PSVSDQQRWLQAMRPPE 1928
                   .|..|..|:  |...|...|     ||.|:..|.|||.   ..:.|.:...|:.....
  Rat   441 RVSFKNGSQSQTHSLQANDTFNKQQWL-----NCIRQAKETVLSAAGQAGLLDSESLSQSPGTEN 500

  Fly  1929 AETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDV 1966
            .|..||...|..|          :||......::..:|
  Rat   501 RELRGETKLEQMD----------QSDSESDCSMDTSEV 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	40/191 (21%)
		PH_ephexin	1805..1931	CDD:269929	33/163 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727	3/23 (13%)
Arhgef3	XP_006252636.1	RhoGEF	152..328	CDD:279015	41/192 (21%)
		PH_RhoGEF3_XPLN	342..474	CDD:269976	31/169 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810