DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and ARHGEF16

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_016856538.1	Gene:	ARHGEF16 / 27237	HGNCID:	15515	Length:	726	Species:	Homo sapiens

Alignment Length:	782	Identity:	223/782 - (28%)
Similarity:	353/782 - (45%)	Gaps:	125/782 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1296 SFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPE-TPKFSTVAR 1359
            ||...:..|..|...:......:.||....|....|....||:|.:..:..|:.. :|
Human     2 SFRAMRAGSRTPQPPSMAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSP------- 59

  Fly  1360 KAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSP--------------LDPERELDAEQTTSWY 1410
                     |.|.....:|..|.||.|...|::.|              |..::.:......:..
Human    60 ---------RVRDDAAFQPQVPAPPQPRPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASK 115

  Fly  1411 AECGVFKQATNGAV----SPRGDEPVTPTPS----------GHGGVSSWYAESGLYQTSGISVAS 1461
            |:.....|:...||    :.|.|..:.|.||          ..||:......:..|:      |:
Human   116 AKTPARHQSFGAAVLSREAARRDPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYR------AA 174

  Fly  1462 SSGSSGVSTGNEAGLGD------------ELSSEPHS------------------LFSNEP-LYQ 1495
            ..|     .|...|.||            |..|:||:                  .|.::| |||
Human   175 MKG-----LGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQ 234

  Fly  1496 MYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEV 1560
                   |...|.|.....||  ::| |...:.||...|...|   :|.....|::..||::|||
Human   235 -------EIQERGLNTSQESD--DDI-LDESSSPEGTQKVDAT---IVVKSYRPAQVTWSQLPEV 286

  Fly  1561 IHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYI 1625
            :...||..|::.||..|||.|||:|||.||..||::|...|:.....  .:.::..:...|||.|
Human   287 VELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKEL--RATVTQMEHHHLFSNI 349

  Fly  1626 VPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKES 1690
            :.|...|:|...:||...:..:::..:|..:.|.||:|||.|:|:|.::....|||::|..|  :
Human   350 LDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISS--N 412

  Fly  1691 LAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQ 1755
            .||::.|..:|..|:|.||.:.|||:|||||:||||||:|.:..|... :.|.|::....|..:.
Human   413 AAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQG-HSERYKAASRALKAIS 476

  Fly  1756 KVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRG 1820
            |:|.||||.|:|.|:..::..:..||:| |.|::|.:.        :..|:|:||||    |:..
Human   477 KLVRQCNEGAHRMERMEQMYTLHTQLDF-SKVKSLPLI--------SASRWLLKRGE----LFLV 528

  Fly  1821 EDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTL--AAGDSLPQLPTKDL 1883
            |:..| |.|..::.:.|.|||:|:|::.|::.|..:.|.||...:.:.:  .....|| ||....
Human   529 EETGL-FRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELP-LPGGGN 591

  Fly  1884 KDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAK 1948
            :..:..:...:|||.|.:.:..:|:||..|.||:.||:.|:...|.:..|  |....|.|||...
Human   592 RSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQWQG--LSSKGDLPQVEIT 654

  Fly  1949 HSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRH 2013
            .::.:.:.|.:.|:..|||.|.:: .|||..|||:|||..||||..:...:.|......|:::..
Human   655 KAFFAKQADEVTLQQADVVLVLQQ-EDGWLYGERLRDGETGWFPEDFARFITSRVAVEGNVRRME 718

  Fly  2014 RL 2015
            ||
Human   719 RL 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	67/181 (37%)
		PH_ephexin	1805..1931	CDD:269929	40/127 (31%)
		SH3_ephexin1_like	1944..1998	CDD:212727	21/53 (40%)
ARHGEF16	XP_016856538.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5908
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4837
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41472
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.890