DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Plekhg5

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_006538986.1	Gene:	Plekhg5 / 269608	MGIID:	2652860	Length:	1103	Species:	Mus musculus

Alignment Length:	693	Identity:	153/693 - (22%)
Similarity:	250/693 - (36%)	Gaps:	188/693 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1212 ISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRA 1276
            ||.||:     ::.:.:.|:.     ||.....|:  |.|...|.:||.:.|. :.:...||..
Mouse   157 ISKKKA-----RRRHTDDPSK-----ECFTLKFDL--NVDIETEIVPAMKKKS-LGEVLLPVFE- 207

  Fly  1277 KQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFS 1341
                        ||.:.....|.....|..|...||......|....:..:|  ...|:::.|..
Mouse   208 ------------RKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKP--GDEGKVEQGVK 258

  Fly  1342 DKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPP----PPPMTGNKSPLD---PER 1399
            |.....||                         .|||:...||    ..|.:..:|.||   |.|
Mouse   259 DSKSLSLP-------------------------ALRPSGAGPPVSERVDPQSRRESSLDILAPGR 298

  Fly  1400 ELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPT----PSG-HGGVSSWYAESGLYQTSGISV 1459
            .  .:..:.:..|.|:           .|.||..|:    |.| .||.||...||  ::....|.
Mouse   299 R--RKNMSEFLGEAGI-----------PGHEPPAPSSCSLPVGSSGGTSSGINES--WKNRAASR 348

  Fly  1460 ASSSGSSGVST---GNEAGLGDELSSEPH--SLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYE 1519
            .|...||..||   ..|....::|.|:.|  |||.   |.:|....:.:..:.:.|.....:..|
Mouse   349 FSGFFSSSPSTSAFSREVDKMEQLESKLHAYSLFG---LPRMPRRLRFDHDSWEEEEEDDEEDEE 410

  Fly  1520 EIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEII 1584
            ..||:.:..                         |.|:.:. |.    .||.|:...|||.:|::
Mouse   411 SSGLRLEDS-------------------------WRELTDG-HE----KLTRRQCHQQEAVWELL 445

  Fly  1585 TSEASYLKSLNLLRRHFMNHNAFL-------DSSVLSAKDRKALFSYI---------------VP 1627
            .:|.||::.|.::.      |.||       :|.:|...:.:.|||.|               ||
Mouse   446 HTEVSYIRKLRVIT------NLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVP 504

  Fly  1628 VHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFC-EHQGRMDRTLRRLKESKESL 1691
            |.|.:.|    ..|..|.:..|.|     :::....|..|:.:| |.:|.|:.....|:::.
Mouse   505 VLEKARR----TRALLQPSDFLKG-----FKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDND--- 557

  Fly  1692 AFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSK-ESPLNREEYESWKLTLALVQ 1755
            .|:.::...|....|..|.|...|..|.||:|:.|||:.:|..| :.|..:|...:   .::.|:
Mouse   558 LFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVT---MISSVE 619

  Fly  1756 KVVGQCNEAANRWEQAFELERIARQL-----------EFPSHVRALAIAPVGVPRAGAKP---RF 1806
            :.:...|....:.::...|..:..::           |....::......:..|..|..|   |.
Mouse   620 RFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQ 684

  Fly  1807 LVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK 1849
            |:..|.|.  :..|:|:|:         .:|.|||:||||:.|
Mouse   685 LLLEGSLR--MKEGKDSKM---------DVYCFLFTDLLLVTK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	48/205 (23%)
		PH_ephexin	1805..1931	CDD:269929	16/45 (36%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Plekhg5	XP_006538986.1	RBD_PLEKHG5	172..246	CDD:340588	19/94 (20%)
		RhoGEF	440..626	CDD:214619	49/206 (24%)
		PH_PLEKHG5_G6	683..781	CDD:270064	16/45 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910