DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Fgd2

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_036016509.1	Gene:	Fgd2 / 26382	MGIID:	1347084	Length:	673	Species:	Mus musculus

Alignment Length:	519	Identity:	104/519 - (20%)
Similarity:	181/519 - (34%)	Gaps:	139/519 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1470 TGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVK 1534
            |..||.....|..:|||     |.:|:                             ...|||...
Mouse    24 TPGEAPGSHSLEDQPHS-----PEHQL-----------------------------SLSPEPWEA 54

  Fly  1535 PRPTALQLVEPKNGPSRTLWSEIPEVI------HSC---ILPTLTSRERSLQEAKFEIITSEASY 1590
            | |....|.......|||..|.:...:      .||   :.|...::|...:....|::.:|.:|
Mouse    55 P-PVKEALKSEFRPVSRTYLSSLKNKLSSGAWRRSCQPGVSPGPETQEPEEKRVVRELLETEQAY 118

  Fly  1591 LKSLNLLRRHFMNH--------NAFLDSSVLSAKDRKALFSYIVPVHEC-SERLLTELEACWQDN 1646
            :..|:||.:.|...        .||.:..|      |.:||.|..::.. ::..|.||:....|.
Mouse   119 VARLHLLDQVFFQELLREAGRSKAFPEDVV------KLIFSNISSIYRFHAQFFLPELQRRVDDW 177

  Fly  1647 IMLLGLSRCIYEIAE--RHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGL 1709
            .....:...|.::|.  :.:..||...|....:..|.     ..:|..||:.:.|::.|.:...|
Mouse   178 AATPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATW-----MDKSQPFQEVVTRIQCSEASSSL 237

  Fly  1710 NLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFEL 1774
            .|...::.|:|||.|..||:.. :.::.|....:.|..:..|.::.......|.|....|:...|
Mouse   238 TLQHHMLEPVQRIPRYELLLKE-YVQKLPAQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGL 301

  Fly  1775 ERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAF 1839
            ..:.::|.....:    :.|...                  ||..|...|::| :|...:..|..
Mouse   302 WDVYQRLGLEDDI----VDPSNT------------------LLREGPVLKISF-RRSDPMERYLV 343

  Fly  1840 LFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMT-------LL 1897
            ||:::||              ||...:|.:.|     |...:...|.||..:..:|       .|
Mouse   344 LFNNMLL--------------YCVPRVLQVGA-----QFQVRTRIDVAGMKVRELTDAEFPHSFL 389

  Fly  1898 ENCDRKTVEL-----------VLSCPSVSDQ-----QRWLQAMRPPEAETPGEKLYESWDCPQV 1945
            .:..::|:||           :.:|.:..||     :.:..|::.|:.:|...|       |||
Mouse   390 VSGKQRTLELQARSRDEMVSWMQACQAAIDQVEKRSETFKAAVQGPQGDTQEPK-------PQV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	41/192 (21%)
		PH_ephexin	1805..1931	CDD:269929	29/148 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727	2/2 (100%)
Fgd2	XP_036016509.1	RhoGEF	105..289	CDD:238091	41/195 (21%)
		PH1_FGD2	321..428	CDD:275421	27/126 (21%)
		FYVE_FGD1_2_4	454..535	CDD:277280
		PH2_FGD1-4	556..658	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810