Protein Alignment Exn and ARHGEF26

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_056410.3
• Gene: ARHGEF26 / 26084
• HGNCID: 24490
• Length: 871
• Species: Homo sapiens
• Alignment Length: 947
• Identity: 257/947 - (27%)
• Similarity: 415/947 - (43%)
• Gaps: 182/947 - (19%)

  Fly  1169 DGEPDLRQRNYNDSGVD--MRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPA 1231
            |||.::   :::.:.:.  .|...:|:|       ::.:.:.|....|.:||.|.....:.....
Human     2 DGESEV---DFSSNSITPLWRRRSIPQP-------HQVLGRSKPRPQSYQSPNGLLITDFPVEDG 56

  Fly  1232 STLFYVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQK----NG-------KSLR 1285
            .||...:.              |.::|.......||  ::|:|...|:    ||       ::..
Human    57 GTLLAAQI--------------PAQVPTASDSRTVH--RSPLLLGAQRRAVANGGTASPEYRAAS 105

  Fly  1286 SRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPE 1350
            .|||:.      .:.:|....|..|.....:...:|||.|..|.:......::        |.|.
Human   106 PRLRRP------KSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTPNA--------PAPC 156

  Fly  1351 TPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPEREL-------DAEQ--- 1405
            ||:.......|......    |..||..|:..|.....:|.|:. ||||.|       .:||
Human   157 TPEEDLTGLTASPVPSP----TANGLAANNDSPGSGSQSGRKAK-DPERGLFPGPQKSSSEQKLP 216

  Fly  1406 -------------------TTSWYAECGVFKQ-------ATNGAVSPRGDEPVTP---------- 1434
                               :|:..|...|.||       |:...:|...::.|.|
Human   217 LQRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSM 281

  Fly  1435 -----TPSGHGGVSSWYAESGLYQTSGI--SVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEP 1492
                 .|.||.|..| ..::.:.....:  .:.|:|....|.:|.:.   |..:|.......::|
Human   282 VEGLGGPLGHAGEES-EVDNDVDSPGSLRRGLRSTSYRRAVVSGFDF---DSPTSSKKKNRMSQP 342

  Fly  1493 LYQ--MYSAAKLESITR----DLEAHGSSDG---------YEEIGLQAKAKPEPLVKPRPTALQL 1542
            :.:  |....|..|:.|    .|:..|:.||         |:|..|...:..|...|.:.:..::
Human   343 VLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKI 407

  Fly  1543 VEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAF 1607
            | ..:.|.|:.||::..|....:..|::..||..|||.||:|:||.|||.||.:|.|.|.|....
Human   408 V-IHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKEL 471

  Fly  1608 LDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERH----FHVYV 1668
            .|:  ::..:|..|||.|..|.|.|::...||||..|:||.:..:|    :|.|:|    |..||
Human   472 SDT--MTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDIS----DIVEKHTASTFDPYV 530

  Fly  1669 AFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVF 1733
            .:|.::....|||::|..:..|  |::.|.|:|:...|..|.:.|||:|||||:||||||:|.:.
Human   531 KYCTNEVYQQRTLQKLLATNPS--FKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTIC 593

  Fly  1734 SKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVP 1798
            .| :|.:..:||..|..|..|.|:|..|||.|.:.|:...:..|..||||       .|.|..:.
Human   594 QK-TPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEF-------KIKPFPLV 650

  Fly  1799 RAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCP 1863
               :..|:||||||||..:   ||..| |.:|.:|..:|.|||:|:|::.|::.|..::|.||..
Human   651 ---SSSRWLVKRGELTAYV---EDTVL-FSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSL 708

  Fly  1864 RSMLTLAAGDSLPQLPTKDLKDQAGKN--------------LILMTLLENCDRKTVELVLSCPSV 1914
            |..|.:.:.|:      ::|....|||              |..:|:|.|...:.||::|...:.
Human   709 RDQLLVESCDN------EELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQ 767

  Fly  1915 SDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQ 1979
            |::.||:.|:.....:.|.::.    ...||....|:.:.:||.|.|::.|||.:.:::.||||:
Human   768 SERARWITALGHSSGKPPADRT----SLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYE 828

  Fly  1980 GERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRLL 2016
            |||:|||..||||....:|:.......:|:::..|||
Human   829 GERLRDGERGWFPMECAKEITCQATIDKNVERMGRLL 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	73/184 (40%)
		PH_ephexin	1805..1931	CDD:269929	44/139 (32%)
		SH3_ephexin1_like	1944..1998	CDD:212727	24/53 (45%)
ARHGEF26	NP_056410.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		11/56 (20%)
		PHA03247	<18..221	CDD:223021	49/244 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..233		33/165 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..310		5/22 (23%)
		RhoGEF	443..621	CDD:459876	74/186 (40%)
		PH_ephexin	643..781	CDD:269929	46/150 (31%)
		SH3_ARHGEF16_26	793..847	CDD:212871	24/53 (45%)