DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and rgf3

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_588115.1	Gene:	rgf3 / 2539437	PomBaseID:	SPCC645.06c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	977	Identity:	192/977 - (19%)
Similarity:	313/977 - (32%)	Gaps:	325/977 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1064 ERFKPHRTRSPDWSKRI-----RDKRLQQKKAISCIEDDSDHYYETLSP-----LGNKRHSTQLV 1118
            :.:.||.:..|.:.||:     ...||.....:|...::|.|.:....|     :.::|.::..|
pombe    28 DTYPPHSSSPPSFQKRLSFSDFSTTRLFSPPFLSKRSNNSPHRFSYSPPQHPASINSRRVASYTV 92

  Fly  1119 RQSQDGNRSGGVRSSHRRSKN--HSASAHTLGEHVVISDDYDSFETD-SDDHG-----DGEPDLR 1175
            :.|..       |:::|:..|  .:::|:|         .|.||... .||..     |.:|.|.
pombe    93 QSSPS-------RTTYRQLPNEPQNSAAYT---------TYSSFPNALFDDFSPNNPLDTDPFLT 141

  Fly  1176 QRNYNDSGVDMRN--------------HRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLY 1226
            ......:.||...              |.||:||.|.:            :||..||       |
pombe   142 SPGNKQNTVDSFRPLPETPVSPGGSLVHPLPRPPLPSS------------VSSHSSP-------Y 187

  Fly  1227 ENTPASTLF------YVECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLR 1285
            ..|.:::|:      .:.||   .:.|  ....|.|.|| .|..|:....:..||.:
pombe   188 STTSSTSLYSLYNDISLSCS---PEPY--LPLSPTRSPA-RTPSPIRLYSSDALRPQ-------- 238

  Fly  1286 SRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPE-----------GSLPALPLEPEIHGSGELDSG 1339
                             |.|:|  |..|:..|.           ..||.:|::.  :.||::.|
pombe   239 -----------------SPLSP--SVEYLTPPNPYSLKSDISSTRQLPKIPVQD--YASGKISS- 281

  Fly  1340 FSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAE 1404
                        |..:...|:|:.|...:..|             .|.:.|
pombe   282 ------------PLITRTHRRAQSETLFSSCR-------------EPWLVG-------------- 307

  Fly  1405 QTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSS------ 1463
            :...|..| .|| .|..|.|              |.|||.......:.....|.:||..
pombe   308 KLYKWCKE-EVF-TALGGLV--------------HEGVSRREVAQVMATLFTIHIASMEFLIAEI 356

  Fly  1464 -GSSGVSTGNEAGLGDELSSEPHSL--FSNEP---------------------------LYQMYS 1498
             ..:.:......||.:.::.|...:  .||||                           .||.||
pombe   357 IAKNILGDWINYGLVEVINLEKLQIAFTSNEPPSGSGVLPFLTNGGCYSYICRSRSCPSKYQCYS 421

  Fly  1499 AAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHS 1563
            ...         |..||       |:..:.|                  |.|...||....:...
pombe   422 CRC---------ARNSS-------LEFTSLP------------------GQSSDTWSIFWNISSL 452

  Fly  1564 CILP-TLTSRERSLQEAKFEIITSEASYLKSLNLLRRHF-----MNHNAFLDSSVLSAKDRKALF 1622
            ..|| :|:.||.:.|....|:|..|:.|:..||.|...|     ...:|.:.|:.: |...:::|
pombe   453 NSLPSSLSKREIARQNNIHELICKESDYVADLNTLAELFRDGIVQQQDAIVPSNRV-ADFIQSVF 516

  Fly  1623 SYIVPVHECSERL-LTEL---EACWQDNIMLLGLSRCIYEIAERHFHV----YVAFCEHQGRMDR 1679
            ..:..:.:...|| |.:|   |......:.::|      :|.....|.    |:.:.:.....|.
pombe   517 GNVESIRQLHSRLFLPQLIMRERLQGPVVSIIG------DILLEWIHAAKSSYINYAKQFPLADE 575

  Fly  1680 TLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEY 1744
            |.:  .|.:.:..|.:.|....:.|.|..|:...||..|.||:.|..|.:|.:      |...|.
pombe   576 TYK--LECQRNTYFARWLAACRSDPRCRRLDFQHFLQRPTQRLQRYTLELDTI------LKHTEQ 632

  Fly  1745 ESW--KLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFL 1807
            .||  :|....|:::...|.|.........|..|| |.|.:                     :.|
pombe   633 SSWDFQLITQAVKELRATCEECDAVIATVLEANRI-RDLSY---------------------QLL 675

  Fly  1808 VKRGELTHLLWRGEDAKLTF--------GKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDY--- 1861
            .|..|..:|..|..:.:..|        ..||..:.|:.||..:.|::.|.|.:...:...|
pombe   676 FKNHESVNLELRDPEREFFFEGIVQRRSDSRLDWLDIHLFLLDNYLIMAKARKDKRTNASRYVVS 740

  Fly  1862 ---CPRSMLTLAAGDSLPQLPTKDLKDQAGK-------NLILMTLLENCDRKT-VELVLSCPSVS 1915
               .|..:|.|:     |::....||....|       ||...:|.....||: |.|.|...:.:
pombe   741 KRPIPLDLLVLS-----PKMDDFQLKSNTNKFLGSLAGNLPQESLTTKSKRKSKVNLELMFDATA 800

  Fly  1916 DQ 1917
            ::
pombe   801 EK 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/196 (22%)
		PH_ephexin	1805..1931	CDD:269929	30/135 (22%)
		SH3_ephexin1_like	1944..1998	CDD:212727
rgf3	NP_588115.1	RhoGEF	470..656	CDD:279015	45/200 (23%)
		PH-like	695..850	CDD:302622	25/113 (22%)
		CNH	939..1236	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840