DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and Ngef

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:XP_038938943.1 Gene:Ngef / 246217 RGDID:1309055 Length:700 Species:Rattus norvegicus


Alignment Length:753 Identity:229/753 - (30%)
Similarity:338/753 - (44%) Gaps:127/753 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  1300 KQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNC-TPLPETPKFSTVARKAKK 1363
            |.:|||..::     ..|....|.||.|.......|      :..| .|:.....|:...|...|
  Rat    15 KSVSSLWKSK-----HGPAEMRPELPPETAKETQNE------EPRCLIPIQRNSLFNRAMRHKHK 68

  Fly  1364 EAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRG 1428
            ....:.||.      ||....|........||                       |.|   .|:|
  Rat    69 ARSMSERRA------NDQADLPETRKSVNEPL-----------------------AFN---LPQG 101

  Fly  1429 DEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEP- 1492
            ..|...||:..|..:...:||           ||:..:|.:......|.|..::...:|....| 
  Rat   102 RLPPWRTPAQRGPGAQEASES-----------SSTPGNGTTPEECPALTDSPTTLTEALQMIHPI 155

  Fly  1493 --------------LYQMY-SAAKLESI-TR---DLEAHGSSDG-------YEEIGLQAKAKPEP 1531
                          |||.| ..:.|:.| ||   |.|..|:|||       .||   :.:.:.||
  Rat   156 PADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIQGNSDGSQAGEDNAEE---EEEEEEEP 217

  Fly  1532 LVKPRPTAL-QLVEPKNGPSR-TLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSL 1594
            ...|...|| |:....|..|| .||.::||:..|.:|..|...|..||||.||::||||||.|||
  Rat   218 ASPPERRALPQICLLSNPHSRFNLWQDLPEIQSSGVLDILQPEETKLQEAMFELVTSEASYYKSL 282

  Fly  1595 NLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEI 1659
            |||..|||.:...  ..:|...:...|||.::.|...|||.|.|||...::||::..:...:|..
  Rat   283 NLLVSHFMENERL--KKILHPSEAHILFSNVLDVMAVSERFLLELEHRMEENIVISDVCDIVYRY 345

  Fly  1660 AERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITR 1724
            |..||.||:.:..:|...:||.::|.:  |..||::.:.:||..|.|.||.|.|||:||.|||||
  Rat   346 AADHFSVYITYVSNQTYQERTYKQLLQ--EKTAFRELIAQLELDPKCKGLPLSSFLILPFQRITR 408

  Fly  1725 LPLLIDAVFSKESPLNREEYESWKLTLAL-----VQKVVGQCNEAANRWEQAFELERIARQLEFP 1784
            |.||:..:      |.|.|..|.:...||     ::.||..|||...:..:..::..|.:::|| 
  Rat   409 LKLLVQNI------LKRVEEGSEREGTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEF- 466

  Fly  1785 SHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK 1849
             .::::.|.        :..|:|:|:|||..:  .|.....|...:.....||.|||:|||::|:
  Rat   467 -KIKSVPII--------SHSRWLLKQGELQQM--SGPKTSRTLRTKKLFREIYLFLFNDLLVICR 520

  Fly  1850 RRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAG--KNLILMTLLENCDRKTVELVLSCP 1912
            :.....:.|||..||.:|.:           ::|:||..  .|:.::.||||.|.:....:|...
  Rat   521 QIPGDKYQVFDSAPRGLLRV-----------EELEDQGQTLANVFILRLLENADDREATYMLKAS 574

  Fly  1913 SVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGW 1977
            |.|:.:||:.::.|..............|||||...|.|.:.:||.|.|||.|::|:..|..|||
  Rat   575 SQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILEKTEDGW 639

  Fly  1978 YQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015
            ..|||:.|...||||.|.|||:.:..:|::|||:..|:
  Rat   640 IFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 73/186 (39%)
PH_ephexin 1805..1931 CDD:269929 38/127 (30%)
SH3_ephexin1_like 1944..1998 CDD:212727 26/53 (49%)
NgefXP_038938943.1 RhoGEF 267..445 CDD:395496 73/187 (39%)
PH_ephexin 467..593 CDD:269929 39/146 (27%)
SH3_ephexin1 606..660 CDD:212872 26/53 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 116 1.000 Domainoid score I5800
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001805
OrthoInspector 1 1.000 - - otm45587
orthoMCL 1 0.900 - - OOG6_105893
Panther 1 1.100 - - O PTHR12845
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1705
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.810

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