DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Arhgef16

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_011248543.1	Gene:	Arhgef16 / 230972	MGIID:	2446219	Length:	721	Species:	Mus musculus

Alignment Length:	761	Identity:	214/761 - (28%)
Similarity:	346/761 - (45%)	Gaps:	123/761 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 EGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRP--ND 1380
            :.||....||...|....||:     |..|:|..|    :.|.:.| |:||     ....|  ::
Mouse    15 DSSLDEKLLEYRFHAELRLDA-----NGNPIPGLP----MVRSSLK-ARAN-----AAFEPDASE 64

  Fly  1381 PPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPR----GDEPVTPTPSGHGG 1441
            |.||||      ||.|.|.......:|...|   ..|..|...: |:    ..:..|.:|:.|
Mouse    65 PLPPPP------SPEDEEPPRPIVLSTQSPA---ALKMGTQQLI-PKSLAVASKAKTKSPARH-- 117

  Fly  1442 VSSWYAESGLYQTSGISVASSSGS-------------------SGVSTGN--------------- 1472
                       |:.|.:|.|...:                   ..|:|||
Mouse   118 -----------QSFGAAVLSKEAARRNPQLFSAPSFSLDDMDMDMVTTGNLRRNLRNQSYRAAMK 171

  Fly  1473 ----EAGLGDELSSEPHSLFSNEPLYQ---MYSAAKLESITRDLEAHGSSDG----YEEI---GL 1523
                .:..||.:...|......|...|   .|.|...:::.|.....||...    |:||   ||
Mouse   172 GPGPPSSKGDSVQLGPKLQALAEEAAQPPSRYPAKNKKTLGRKRAHKGSFKDDPQLYQEIRERGL 236

  Fly  1524 QAKAKPEPLVKPRPTA--------LQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAK 1580
            ....:.:..:...|:.        ..:|.....|::..||::|||:.|.:|.||::.||..|||.
Mouse   237 NTSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAI 301

  Fly  1581 FEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQD 1645
            |||:|||.|||.||::|...|:.....  .:.::..:...|||.|:.|...|::....||...:.
Mouse   302 FEILTSEFSYLHSLSILVTEFLQSREL--RATMTQTEHHHLFSNILDVMSASQKFFEALEQRHKA 364

  Fly  1646 NIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLN 1710
            .:.:..:|..:.:.|:.|||.|:|:|.::....|||::|  |..:.||:..|:.:|..|:|.||.
Mouse   365 QVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKL--SNSNAAFRDVLKEIEKRPACGGLP 427

  Fly  1711 LHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELE 1775
            :.|||:|||||:||||||.|.:..|... :.|.|::....|..:.|:|.||||.|::.|:..::.
Mouse   428 MISFLILPMQRVTRLPLLTDTLCLKTQG-HPERYKAASQALKAISKLVKQCNEGAHKMERTEQIY 491

  Fly  1776 RIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFL 1840
            .:..||:| ..|::|.:.        :..|:|:|||||..|    |::.: |.|..::.:.|.||
Mouse   492 TLNMQLDF-GKVKSLPLI--------SASRWLLKRGELFLL----EESSI-FRKIASRPTCYLFL 542

  Fly  1841 FSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGD-SLPQLPTKDLKDQAGKNLILMTLLENCDRKT 1904
            |:|:|::.|::.|..:.|.||.....:.:...: |.|.||....:..:......:.||.|.:.:.
Mouse   543 FNDVLVVTKKKSEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQ 607

  Fly  1905 VELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNV 1969
            .:::||..|.||:.||:.|:...|.:..|  :....:.|||....:|.:.:.|.:.|:..|:|.|
Mouse   608 EQILLSSDSASDRARWITALTYKERQWQG--ITNKGELPQVEVTKAYFAKQADEITLQQADIVLV 670

  Fly  1970 SRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015
            .:: .|||..|||:|||..||||.|:...:.|......|:::..||
Mouse   671 LQE-EDGWLHGERLRDGETGWFPESFAHSITSRVAVEGNVRRMERL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	65/181 (36%)
		PH_ephexin	1805..1931	CDD:269929	38/126 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	22/53 (42%)
Arhgef16	XP_011248543.1	RhoGEF	300..478	CDD:366202	65/182 (36%)
		PH_ephexin	501..634	CDD:269929	40/145 (28%)
		SH3_ARHGEF16_26	645..696	CDD:212871	22/51 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5824
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4837
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12845
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.890