Protein Alignment Exn and Arhgef16

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_011248543.1
• Gene: Arhgef16 / 230972
• MGIID: 2446219
• Length: 721
• Species: Mus musculus
• Alignment Length: 761
• Identity: 214/761 - (28%)
• Similarity: 346/761 - (45%)
• Gaps: 123/761 - (16%)

  Fly  1318 EGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRP--ND 1380
            :.||....||...|....||:     |..|:|..|    :.|.:.| |:||     ....|  ::
Mouse    15 DSSLDEKLLEYRFHAELRLDA-----NGNPIPGLP----MVRSSLK-ARAN-----AAFEPDASE 64

  Fly  1381 PPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPR----GDEPVTPTPSGHGG 1441
            |.||||      ||.|.|.......:|...|   ..|..|...: |:    ..:..|.:|:.|
Mouse    65 PLPPPP------SPEDEEPPRPIVLSTQSPA---ALKMGTQQLI-PKSLAVASKAKTKSPARH-- 117

  Fly  1442 VSSWYAESGLYQTSGISVASSSGS-------------------SGVSTGN--------------- 1472
                       |:.|.:|.|...:                   ..|:|||
Mouse   118 -----------QSFGAAVLSKEAARRNPQLFSAPSFSLDDMDMDMVTTGNLRRNLRNQSYRAAMK 171

  Fly  1473 ----EAGLGDELSSEPHSLFSNEPLYQ---MYSAAKLESITRDLEAHGSSDG----YEEI---GL 1523
                .:..||.:...|......|...|   .|.|...:::.|.....||...    |:||   ||
Mouse   172 GPGPPSSKGDSVQLGPKLQALAEEAAQPPSRYPAKNKKTLGRKRAHKGSFKDDPQLYQEIRERGL 236

  Fly  1524 QAKAKPEPLVKPRPTA--------LQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAK 1580
            ....:.:..:...|:.        ..:|.....|::..||::|||:.|.:|.||::.||..|||.
Mouse   237 NTSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAI 301

  Fly  1581 FEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQD 1645
            |||:|||.|||.||::|...|:.....  .:.::..:...|||.|:.|...|::....||...:.
Mouse   302 FEILTSEFSYLHSLSILVTEFLQSREL--RATMTQTEHHHLFSNILDVMSASQKFFEALEQRHKA 364

  Fly  1646 NIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLN 1710
            .:.:..:|..:.:.|:.|||.|:|:|.::....|||::|  |..:.||:..|:.:|..|:|.||.
Mouse   365 QVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKL--SNSNAAFRDVLKEIEKRPACGGLP 427

  Fly  1711 LHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELE 1775
            :.|||:|||||:||||||.|.:..|... :.|.|::....|..:.|:|.||||.|::.|:..::.
Mouse   428 MISFLILPMQRVTRLPLLTDTLCLKTQG-HPERYKAASQALKAISKLVKQCNEGAHKMERTEQIY 491

  Fly  1776 RIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFL 1840
            .:..||:| ..|::|.:.        :..|:|:|||||..|    |::.: |.|..::.:.|.||
Mouse   492 TLNMQLDF-GKVKSLPLI--------SASRWLLKRGELFLL----EESSI-FRKIASRPTCYLFL 542

  Fly  1841 FSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGD-SLPQLPTKDLKDQAGKNLILMTLLENCDRKT 1904
            |:|:|::.|::.|..:.|.||.....:.:...: |.|.||....:..:......:.||.|.:.:.
Mouse   543 FNDVLVVTKKKSEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQVNLLHNSEGRQ 607

  Fly  1905 VELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNV 1969
            .:::||..|.||:.||:.|:...|.:..|  :....:.|||....:|.:.:.|.:.|:..|:|.|
Mouse   608 EQILLSSDSASDRARWITALTYKERQWQG--ITNKGELPQVEVTKAYFAKQADEITLQQADIVLV 670

  Fly  1970 SRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRL 2015
            .:: .|||..|||:|||..||||.|:...:.|......|:::..||
Mouse   671 LQE-EDGWLHGERLRDGETGWFPESFAHSITSRVAVEGNVRRMERL 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	64/180 (36%)
		PH_ephexin	1805..1931	CDD:269929	38/126 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	22/53 (42%)
Arhgef16	XP_011248543.1	RhoGEF	300..478	CDD:459876	65/182 (36%)
		PH_ephexin	501..634	CDD:269929	40/145 (28%)
		SH3_ARHGEF16_26	645..696	CDD:212871	22/51 (43%)