DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and FGD1

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_004454.2	Gene:	FGD1 / 2245	HGNCID:	3663	Length:	961	Species:	Homo sapiens

Alignment Length:	775	Identity:	171/775 - (22%)
Similarity:	285/775 - (36%)	Gaps:	204/775 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1253 GPERIPAPETKGPVHQEQA----------PVLRAKQKNGKSLRSRLRKSLVGSSFDTK------- 1300
            ||.....|.|..|.....|          |.|.|::.:|.:|...|....||.| ||.
Human    11 GPSEPEHPATNPPGAAPPACADSDPGASEPGLLARRGSGSALGGPLDPQFVGPS-DTSLGAAPGH 74

  Fly  1301 QLSSLAPT-------RSTFYVEDPEGSLPALPLEPEIH-------GSGELDSGFSDKNCTPLPET 1351
            ::....|:       |.::::   |||.|    .|.:|       .|..||.|   ::..|.||.
Human    75 RVLPCGPSPQHHRALRFSYHL---EGSQP----RPGLHQGNRILVKSLSLDPG---QSLEPHPEG 129

  Fly  1352 PKFSTVARKAKKEAKANR---RRTTIGLRPNDPPPP--------PPPMTGNKSPLDPERELDAEQ 1405
            |:..........|..:.|   .:...|.:|..||.|        |||:  ...|..|.|.|.|:.
Human   130 PQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPL--EPIPPPPSRPLPADP 192

  Fly  1406 TTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVST 1470
            ..:             ..::||.:    .:||. ..|||...:   ::...:.|||.....|.|.
Human   193 RVA-------------KGLAPRAE----ASPSS-AAVSSLIEK---FEREPVIVASDRPVPGPSP 236

  Fly  1471 GNEAGLGDELSSEPHSL---FSNEPLYQMYSAAKLESI------TRDLEAHGSSD-GYEEIGLQA 1525
            |         ..||..|   .|..|:.|:........:      .||.|...:.| |.:.|...:
Human   237 G---------PPEPVMLPQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPS 292

  Fly  1526 KAK----------PEPLVKPRPTAL-----QLVEPKNGPSRTLWSEIPE------------VIHS 1563
            .::          |...:.|.|.||     .|.:|....|:.:.|::.|            .|..
Human   293 NSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLEEEDDEEEEEEKDREIPV 357

  Fly  1564 CILPTLTSRERSLQEAKF----EIITSEASYLKSLNLLRRHF--------MNHNAFLDSSVLSAK 1616
            .::....|.|.::|:..|    |::.:|.:|:..|:||.:.|        .|.::|....|
Human   358 PLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVV---- 418

  Fly  1617 DRKALFSYIVPVHEC--SERLLTELEACWQ--DNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRM 1677
              ..:||.|..:: |  .:.||.|||...:  |....:|      :|.::.......:.|:....
Human   419 --HGIFSNICSIY-CFHQQFLLPELEKRMEEWDRYPRIG------DILQKLAPFLKMYGEYVKNF 474

  Fly  1678 DRTLRRLKE-SKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSK---ESP 1738
            ||.:..:.. ::.|..|:..:..::...:|..|.|...::.|:|||.|..||:.....|   .||
Human   475 DRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSP 539

  Fly  1739 LNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAK 1803
            .:::..:|    |.|:.......|.|..:.|:..:|.::...|.....:    ::|.
Human   540 DSKDAQKS----LELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDI----VSPT-------- 588

  Fly  1804 PRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRR----GESCFSVFDYCPR 1864
             :.|:|.|   |:|      ||: .|..|....|..||:|.||.|..|    |:. |||     |
Human   589 -KELIKEG---HIL------KLS-AKNGTTQDRYLILFNDRLLYCVPRLRLLGQK-FSV-----R 636

  Fly  1865 SMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAM 1924
            :.:.:   |.:      :||:.:..||....|:....|   .|.|...:..:::.|:||:
Human   637 ARIDV---DGM------ELKESSNLNLPRTFLVSGKQR---SLELQARTEEEKKDWVQAI 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/201 (22%)
		PH_ephexin	1805..1931	CDD:269929	34/124 (27%)
		SH3_ephexin1_like	1944..1998	CDD:212727
FGD1	NP_004454.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..353		83/384 (22%)
		SH3-binding. /evidence=ECO:0000255	171..187		5/17 (29%)
		RhoGEF	376..559	CDD:238091	43/199 (22%)
		PH1_FGD1	591..698	CDD:275392	34/122 (28%)
		PH	591..688	CDD:278594	34/122 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..726
		FYVE_FGD1_2_4	725..789	CDD:277280
		PH2_FGD1-4	815..920	CDD:270056
		PH	823..921	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..961
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810