DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and Fgd4

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:NP_001288746.1 Gene:Fgd4 / 224014 MGIID:2183747 Length:887 Species:Mus musculus


Alignment Length:761 Identity:160/761 - (21%)
Similarity:274/761 - (36%) Gaps:204/761 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1280 NGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALP-------LEPEIHGSGELD 1337
            ||::...|          .|.......|.:..:....|...:|.:|       .:|.:.     :
Mouse    75 NGRTPAKR----------STASAKPQVPPKPLYLQNSPSSHIPQVPRHKALPSAKPRME-----E 124

  Fly  1338 SGFSDKNCTPLPETPKFSTVAR------------KAKKEAKANRR-RTTIGLRPNDPPPPPPPMT 1389
            |..:..:||...:..|.|.:..            ..:|::..|.. ..|:| :|.....||....
Mouse   125 SNPAPTSCTSKGKHSKVSDLISHFEGGSVLSSYIDLQKDSTMNLNIPQTLG-QPGLTSSPPRKFL 188

  Fly  1390 GNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRG-----DEPVTPTPSGHGGVSSWYAES 1449
            ...||  .::|.|.:||...:. |     ..||.|:.:.     ||                .|:
Mouse   189 PQHSP--QKQENDPDQTQGQHG-C-----LANGVVAAQNQMECEDE----------------KET 229

  Fly  1450 GLYQTSGISVASSSGSSGVSTG--NEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAH 1512
            .|.....|..|::|..:.|..|  ||. :.|..||..:|                    .|..|.
Mouse   230 TLSPEMAIQTAAASPDTHVLNGERNET-ITDSASSIANS--------------------HDENAS 273

  Fly  1513 GSS---DGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTL----- 1569
            .||   .| .::||.:| :.||.:.     .:|.|.:||            :::..|.||     
Mouse   274 DSSCRTPG-TDLGLPSK-EGEPGMD-----AELQERENG------------VNTMGLDTLDQHHE 319

  Fly  1570 --TSRERSLQEAKFEIITSEASYLKSLNLLRRHF-------MNHNAFLDSSVLSAKDRKALFSYI 1625
              .:.|:.|.:...|::.:|.:|:..|:||.:.|       .|..:|      .|:....:||.|
Mouse   320 VKETNEQKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSF------PAEMVNKIFSNI 378

  Fly  1626 VPVHEC-SERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKE 1689
            ..::.. |:.||.|||...|:    ...:..|.:|.::.......:.|:....|..:..:|...|
Mouse   379 SSINAFHSKFLLPELEKRMQE----WETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKTMTE 439

  Fly  1690 SL-AFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLAL 1753
            .: .|:...|.::....|..|.|...::.|:|||.|..:|:.....|.|| :..::...|.:|.:
Mouse   440 RVPQFKSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSP-DSPDWNDAKKSLEI 503

  Fly  1754 VQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLW 1818
            :.......|.|..:.|...:|..|...|.....:    :.|         ...|:|.|::..|..
Mouse   504 ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDI----VNP---------SNELIKEGQILKLAA 555

  Fly  1819 RGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDL 1883
            |...|:          ..|.|||:::||.|..|.....|.|     ::.|....|.:..:.|.:.
Mouse   556 RNTSAQ----------ERYLFLFNNMLLYCVPRFSLVGSKF-----TVRTRVGIDGMKIVETHNE 605

  Fly  1884 K-----DQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCP 1943
            :     ..:||            .:|:||..|  |..|::.|::|::  |:.....:.:|::  .
Mouse   606 EYPHTFQISGK------------ERTLELQAS--SEQDKEEWIKALQ--ESIDAFHQRHETF--R 652

  Fly  1944 QVVAKHSYESDEP-DVLQLELGDVVNVSRKLPDGWYQGERIRDGAV 1988
            ..:||   |:|.| :|...|||       |....|     |||..|
Mouse   653 NAIAK---ENDIPLEVSTAELG-------KRAPRW-----IRDNEV 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 42/190 (22%)
PH_ephexin 1805..1931 CDD:269929 30/130 (23%)
SH3_ephexin1_like 1944..1998 CDD:212727 15/46 (33%)
Fgd4NP_001288746.1 RhoGEF 331..512 CDD:279015 42/191 (22%)
PH 544..641 CDD:278594 30/127 (24%)
PH1_FDG4 544..637 CDD:275434 28/121 (23%)
FYVE_FGD1_2_4 675..739 CDD:277280 5/14 (36%)
PH2_FGD1-4 758..860 CDD:270056
PH 776..860 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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