Protein Alignment Exn and Arhgef19

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_766108.1
• Gene: Arhgef19 / 213649
• MGIID: 1925912
• Length: 802
• Species: Mus musculus
• Alignment Length: 870
• Identity: 229/870 - (26%)
• Similarity: 361/870 - (41%)
• Gaps: 186/870 - (21%)

  Fly  1251 DFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVE 1315
            |.||.....|...||....:.||...:|:                              |..:||
Mouse     2 DCGPPATLQPHLAGPPGTARRPVAVCQQE------------------------------SLSFVE 36

  Fly  1316 DPEGSL--PALPLEP-EIHGSGELDSGFSDKNCTPL-----------PETPKFSTVARKAKKEAK 1366
            .|...|  ...|:.| |:...|   |.:|.....||           |:|...||         .
Mouse    37 LPPSRLCVDLFPIAPEELQAPG---SRWSLATPAPLQGLLWPTSPGGPDTHIAST---------S 89

  Fly  1367 ANRRRTTIGLRPNDPPPPPPPMT--GNKSPLDPEREL--DAEQTTSWYAECGVFKQATNGAVSPR 1427
            ...|....|..|:.|...||.:.  .:...:.|:|..  ...:.::|........:...|..:|.
Mouse    90 GGMRPGRAGSWPHCPGAQPPTLVEPWSSQHMQPQRRASHSGSEKSAWRKMQVYHNEEATGTETPT 154

  Fly  1428 G---------------DEPVTPTPSGH--GGVSSWYAESGLYQTS------------GISVA--- 1460
            |               .||.....||:  ||:.:  .|...:..|            |.|.|
Mouse   155 GLLETGQAAQEQALCALEPGPQELSGNARGGLEA--PERRRFSASELMTRLHSSLRLGRSTATRV 217

  Fly  1461 --SSSGSSGVSTG-------------------------NEAGLG---------DELSSEPHS--- 1486
              |.||:..:..|                         ||...|         |:.:.:|.|
Mouse   218 LTSGSGAGAIREGKLPVRESRRAETRADSVSLPGPVDLNEVHGGLVEPRLDTQDKPTQDPSSATE 282

  Fly  1487 -----LFSNEPLYQMYS--AAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPR-----PTA 1539
                 ...|..|||.||  |:..|...:..|..|..||.|    .|:..|.|   ||     .::
Mouse   283 RRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDGAE----GAEEGPGP---PRANLSPSSS 340

  Fly  1540 LQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNH 1604
            .:......|.:.:||.:||:|..|.:|.||:.|:..|||||||:|||||||:.||::...||:..
Mouse   341 FRAQRSTRGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGS 405

  Fly  1605 NAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVA 1669
            ...  |..|..:|::.|||.:..|...|||.|.:||...:.:::...:...:.........||:.
Mouse   406 VEL--SECLGTQDKQWLFSKLPEVKSTSERFLHDLEQRLEADVLRFSVCDVVLHHCPAFRRVYLP 468

  Fly  1670 FCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFS 1734
            :..:|...:||.:||  ..|:..|...|.|||.||.|..|.|.|||:||.||:|||.:|::.:..
Mouse   469 YVTNQAYQERTYQRL--LLENPKFPGILARLEESPVCQRLPLTSFLILPFQRVTRLKMLVENILK 531

  Fly  1735 KESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPR 1799
            :.:|.:::|..:.|...|| :::|.:||.:....::..||..:::::.|...:..|.
Mouse   532 RTAPGSQDEDMATKAFSAL-KELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLI-------- 587

  Fly  1800 AGAKPRFLVKRGELTHL--LWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYC 1862
              ::.|:||:.|||..|  |.....|||    :|:..::|..||:|.|||.:|:....|:||.:.
Mouse   588 --SQARWLVRHGELVELAPLPAAPPAKL----KLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHA 646

  Fly  1863 PRSMLTLAAGDSLPQLPTKD--LKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR 1925
                       ::.:|..:|  ||.|.....:.:..|.:..|...:|:|...:.|::|||:.|:|
Mouse   647 -----------NMAELQVRDLSLKLQGIPGHVFLLRLLHGQRARHQLLLRARTESEKQRWISALR 700

  Fly  1926 PPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGW 1990
            |...:...|...:..|.|||....:|::.:||.|.||..|::.|..:..|||.:|.|:.||..||
Mouse   701 PSSPQEDKEITCDGEDRPQVQCVRTYKALQPDELTLEKTDILAVKTRTSDGWLEGVRLADGEKGW 765

  Fly  1991 FPGSYTEELNSAHVRARNLKQRHRL 2015
            .|.::..|::|...|.|||::..|:
Mouse   766 VPQAHVVEISSLSARLRNLREYKRV 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	61/180 (34%)
		PH_ephexin	1805..1931	CDD:269929	39/129 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	20/53 (38%)
Arhgef19	NP_766108.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..136		12/67 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..192		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..286		10/67 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..343		10/42 (24%)
		RhoGEF	382..558	CDD:459876	61/180 (34%)
		PH_ephexin	580..706	CDD:269929	40/150 (27%)
		SH3	719..773	CDD:473055	20/53 (38%)