DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Arhgef19

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001366576.1	Gene:	Arhgef19 / 213649	MGIID:	1925912	Length:	802	Species:	Mus musculus

Alignment Length:	870	Identity:	229/870 - (26%)
Similarity:	361/870 - (41%)	Gaps:	186/870 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1251 DFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVE 1315
            |.||.....|...||....:.||...:|:                              |..:||
Mouse     2 DCGPPATLQPHLAGPPGTARRPVAVCQQE------------------------------SLSFVE 36

  Fly  1316 DPEGSL--PALPLEP-EIHGSGELDSGFSDKNCTPL-----------PETPKFSTVARKAKKEAK 1366
            .|...|  ...|:.| |:...|   |.:|.....||           |:|...||         .
Mouse    37 LPPSRLCVDLFPIAPEELQAPG---SRWSLATPAPLQGLLWPTSPGGPDTHIAST---------S 89

  Fly  1367 ANRRRTTIGLRPNDPPPPPPPMT--GNKSPLDPEREL--DAEQTTSWYAECGVFKQATNGAVSPR 1427
            ...|....|..|:.|...||.:.  .:...:.|:|..  ...:.::|........:...|..:|.
Mouse    90 GGMRPGRAGSWPHCPGAQPPTLVEPWSSQHMQPQRRASHSGSEKSAWRKMQVYHNEEATGTETPT 154

  Fly  1428 G---------------DEPVTPTPSGH--GGVSSWYAESGLYQTS------------GISVA--- 1460
            |               .||.....||:  ||:.:  .|...:..|            |.|.|
Mouse   155 GLLETGQAAQEQALCALEPGPQELSGNARGGLEA--PERRRFSASELMTRLHSSLRLGRSTATRV 217

  Fly  1461 --SSSGSSGVSTG-------------------------NEAGLG---------DELSSEPHS--- 1486
              |.||:..:..|                         ||...|         |:.:.:|.|
Mouse   218 LTSGSGAGAIREGKLPVRESRRAETRADSVSLPGPVDLNEVHGGLVEPRLDTQDKPTQDPSSATE 282

  Fly  1487 -----LFSNEPLYQMYS--AAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPR-----PTA 1539
                 ...|..|||.||  |:..|...:..|..|..||.|    .|:..|.|   ||     .::
Mouse   283 RRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDGAE----GAEEGPGP---PRANLSPSSS 340

  Fly  1540 LQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNH 1604
            .:......|.:.:||.:||:|..|.:|.||:.|:..|||||||:|||||||:.||::...||:..
Mouse   341 FRAQRSTRGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGS 405

  Fly  1605 NAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVA 1669
            ...  |..|..:|::.|||.:..|...|||.|.:||...:.:::...:...:.........||:.
Mouse   406 VEL--SECLGTQDKQWLFSKLPEVKSTSERFLHDLEQRLEADVLRFSVCDVVLHHCPAFRRVYLP 468

  Fly  1670 FCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFS 1734
            :..:|...:||.:||  ..|:..|...|.|||.||.|..|.|.|||:||.||:|||.:|::.:..
Mouse   469 YVTNQAYQERTYQRL--LLENPKFPGILARLEESPVCQRLPLTSFLILPFQRVTRLKMLVENILK 531

  Fly  1735 KESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPR 1799
            :.:|.:::|..:.|...|| :::|.:||.:....::..||..:::::.|...:..|.
Mouse   532 RTAPGSQDEDMATKAFSAL-KELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLI-------- 587

  Fly  1800 AGAKPRFLVKRGELTHL--LWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYC 1862
              ::.|:||:.|||..|  |.....|||    :|:..::|..||:|.|||.:|:....|:||.:.
Mouse   588 --SQARWLVRHGELVELAPLPAAPPAKL----KLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHA 646

  Fly  1863 PRSMLTLAAGDSLPQLPTKD--LKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR 1925
                       ::.:|..:|  ||.|.....:.:..|.:..|...:|:|...:.|::|||:.|:|
Mouse   647 -----------NMAELQVRDLSLKLQGIPGHVFLLRLLHGQRARHQLLLRARTESEKQRWISALR 700

  Fly  1926 PPEAETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGW 1990
            |...:...|...:..|.|||....:|::.:||.|.||..|::.|..:..|||.:|.|:.||..||
Mouse   701 PSSPQEDKEITCDGEDRPQVQCVRTYKALQPDELTLEKTDILAVKTRTSDGWLEGVRLADGEKGW 765

  Fly  1991 FPGSYTEELNSAHVRARNLKQRHRL 2015
            .|.::..|::|...|.|||::..|:
Mouse   766 VPQAHVVEISSLSARLRNLREYKRV 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	62/181 (34%)
		PH_ephexin	1805..1931	CDD:269929	39/129 (30%)
		SH3_ephexin1_like	1944..1998	CDD:212727	20/53 (38%)
Arhgef19	NP_001366576.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..136		12/67 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..192		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..286		10/67 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..343		10/42 (24%)
		RhoGEF	382..558	CDD:395496	61/180 (34%)
		PH_ephexin	580..706	CDD:269929	40/150 (27%)
		SH3	719..773	CDD:418401	20/53 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910