Protein Alignment Exn and Plekhg6

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_941006.2
• Gene: Plekhg6 / 213522
• MGIID: 2682298
• Length: 787
• Species: Mus musculus
• Alignment Length: 596
• Identity: 138/596 - (23%)
• Similarity: 228/596 - (38%)
• Gaps: 132/596 - (22%)

  Fly  1386 PPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPT--------PSGHGGV 1442
            ||   |:.||   :.|.|.:..::.........:|.|.:.|||...|.|:        |...|
Mouse     6 PP---NEGPL---QGLVASRIETYGGRHQTSAHSTAGNLFPRGGPGVDPSRRRLQHYVPFAKG-- 62

  Fly  1443 SSWYAESGLYQTSGIS-VASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESIT 1506
                  ||  ||.|:| :...........|:..|:|     .|||             .||:.:|
Mouse    63 ------SG--QTRGMSPLVLREPDPEKRHGSYFGVG-----PPHS-------------PKLKEVT 101

  Fly  1507 RDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTL---WSEIPEVIHSCILPT 1568
            |..|.......:...|:       |.:.|.......:......:.|:   |.|:          .
Mouse   102 RAHELEIRLHTFSMFGM-------PRLPPEDRRHWEIGEGGDSALTMEKSWKEL----------V 149

  Fly  1569 LTSRE--RSL---QEAKFEIITSEASYLKSL----NLLRRHFMNHNAFLDSSVLSAKDRKALFSY 1624
            |..:|  |.|   |||.:|::|:|..||:.|    :||....:|....   .:|:....:.||..
Mouse   150 LEHKEMNRQLCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQRV---GLLTEVSAETLFGN 211

  Fly  1625 IVPVHECSERLLTE-LEACWQDN------IMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLR 1682
            :..:.....|...| |:...:|.      :..:.|........:| |..||.:|.   |:.:|:.
Mouse   212 VPNLIRAHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQR-FQPYVQYCL---RVKQTMA 272

  Fly  1683 RLKESKES----LAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREE 1743
            ..:|.:::    ..|.|..|:.:.|..   ..|...|:.|.||||:.|||:.|| .|.||..|.:
Mouse   273 YAREQQDTNPLFHTFVQWCEKHKRSGR---QTLGDLLIKPHQRITKYPLLLQAV-RKRSPEPRAQ 333

  Fly  1744 YESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQL-----------EFPSHVRALAIAPVGV 1797
             |:....:..|:..:...|....:.|:...|..:|:::           |...::|..:...:..
Mouse   334 -EALNAMIEAVESFLRHINGQVRQGEEQESLMAVAQRIGPYEVLEPSSEEVEKNLRPFSTLDLMT 397

  Fly  1798 PRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK--RRGESCFSVFD 1860
            |..|..|.:      ...||..| ..::..| |..|:.:|.|||||:||:.|  |:.:....:
Mouse   398 PVLGVAPEY------TRQLLLEG-PVRVKEG-REGKMDVYLFLFSDVLLVTKPQRKADRAKVI-- 452

  Fly  1861 YCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMR 1925
               |..|      .|.:|..:.|:|   .|..|:..|......:..|.:.|||.:::.|||:  :
Mouse   453 ---RPPL------MLEKLVCRPLRD---PNSFLLIHLTEFQCVSSALTVHCPSSTERARWLE--K 503

  Fly  1926 PPEAETPGEKL 1936
            ...|:|..:||
Mouse   504 TQHAQTTLQKL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	47/196 (24%)
		PH_ephexin	1805..1931	CDD:269929	33/127 (26%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Plekhg6	NP_941006.2	RhoGEF	165..351	CDD:366202	48/197 (24%)
		PH_PLEKHG5_G6	408..505	CDD:270064	32/114 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	533..762

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810