DRSC/TRiP Functional Genomics Resources

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Protein Alignment Exn and Arhgef11

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:XP_006501327.1 Gene:Arhgef11 / 213498 MGIID:2441869 Length:1579 Species:Mus musculus


Alignment Length:1352 Identity:278/1352 - (20%)
Similarity:457/1352 - (33%) Gaps:376/1352 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   916 TSSSSSGEATLTTDTISLSSNC--YESISH-----IRRSRVATTQNQGHGSA--------GSCIQ 965
            ||.|...:.:.|::|..|...|  .:...|     :...|:...|:...|.|        |..| 
Mouse    42 TSPSHHRQPSDTSETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMRAGVKEGDRI- 105

  Fly   966 LSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSAGSRDSGKPGDKR------ 1024
            :..:|:.:|.||..:...|.:|. |.....:.||:.    ||:|.|...::....|..|      
Mouse   106 IKVNGTMVTNSSHLEVVKLIKSG-AYVALTLLGSSP----SSIGVSGLQQNPSLSGGPRVNPMIP 165

  Fly  1025 -----------SSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHR------TR 1072
                       ..|.|..       .:.|.|:.:..|....|     ::|:..|..:      :|
Mouse   166 PPPPPPPLPPPQHITGPK-------PLQDPEVQKHATQILRN-----MLRQEEKELQRICEVYSR 218

  Fly  1073 SP--------DWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRS-G 1128
            :|        :.::| |..:||.|     |:.::....:.|...|.....|...|.|.|...: .
Mouse   219 NPASLLEEQIEGARR-RVTQLQLK-----IQQETGGLVDVLPLCGETSQRTCEGRLSVDSQEADS 277

  Fly  1129 GVRSSHRRSKNHSASAHTLGEHVVISD-DYDSFETDS------DDHGDGEPDLRQRNYNDSGVDM 1186
            |:.|...|..  |.|...:..:.|:|| ..||.:|..      ..|       .:|..:|:.|..
Mouse   278 GLDSGTERFP--SISESLVNRNSVLSDPGLDSPQTSPVILARVGQH-------HRRQGSDAAVHP 333

  Fly  1187 RNH----RLPKP----------PPPQNQVYEFVRKFKDFISSKKSPKGSQQKLY----------E 1227
            .||    :.|||          |...|...:.:  |:|....|..|      .|          :
Mouse   334 LNHQGIDQSPKPLIIGPEEDYDPGYFNNESDII--FQDLEKLKSHP------AYLVVFLRYIFSQ 390

  Fly  1228 NTPASTLFYVECSKRTEDVYENTD------------------FGPERIPAPE------------- 1261
            ..|...|||: ||    :||:.|:                  ..|.|:..||             
Mouse   391 ADPGPLLFYL-CS----EVYQQTNPKDSRNLGKDIWNIFLEKNAPLRVKIPEMLQAEIDLRLRNS 450

  Fly  1262 --TKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSL--APTRSTFYVEDPEGSLP 1322
              .:..:::.|..|:...|:.....||: |...:||.:....|..|  .|.|..   :..|..|.
Mouse   451 EDPRSALYEAQEAVMPEIQEQINDYRSK-RTLGLGSLYGENDLLDLDGDPLRER---QMAEKQLA 511

  Fly  1323 ALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPP 1387
            ||         |::.|.:.:....|:               :...|...:..|:|..:   ..|.
Mouse   512 AL---------GDILSKYEEDRSAPM---------------DFAVNTYMSHTGIRLRE---SRPS 549

  Fly  1388 MTGNKSPLDPERE-------LDAEQTTSWYAECGVFKQATNGAV-----SPRGD---------EP 1431
            .|..|:...|:::       ...:|:::...|....:......:     .|:..         .|
Mouse   550 STAEKTQSAPDKDKWLPFFPKTKKQSSNSKKEKDALEDKKRNPILRYIGKPKSSSQSTFHIPLSP 614

  Fly  1432 VTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGN--EAGLGDELSSEPHSLFSNEPL- 1493
            |...|.....:...:..|..|.      ....|:..:|||:  |..|..:.|.....|..:|.| 
Mouse   615 VEVKPGNVRNIIQHFENSHQYD------VPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLK 673

  Fly  1494 --YQMYSAAKLESITR-----DLEA--------HGSSDGYEEIGLQAKAKPEPLVKPRPTALQLV 1543
              .:|..:.|.|::.|     |::|        ..:|.....:..::...|.|...|:.....:.
Mouse   674 GREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSASSLSTRSLENPTPPFTPKMGRRSIE 738

  Fly  1544 EPKNG------------------------PSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEII 1584
            .|..|                        |....|.   ..:...::..||.||...||...|:.
Mouse   739 SPNLGFCTDVILPHLLEDDLGQLSDLEPEPEVQNWQ---HTVGKDVVANLTQREIDRQEVINELF 800

  Fly  1585 TSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALF---SYIVPVHE--CSERLLTELEACWQ 1644
            .:|||:|::|.:|...|  :......:::..::...||   ..::.:|.  |........|....
Mouse   801 VTEASHLRTLRVLDLIF--YQRMKKENLMPREELSRLFPNLPELIEIHNSWCEAMKKLREEGPII 863

  Fly  1645 DNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGL 1709
            .:|..|.|:|......|....|...||.:|. :...|.|.|:.||| .||..::..|:.|.|..|
Mouse   864 RDISDLMLARFDGPAREELQQVAAQFCSYQS-VALELIRTKQRKES-RFQLFMQEAESHPQCRRL 926

  Fly  1710 NLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQ--KVVGQCNEAANRWEQAF 1772
            .|...::..|||:|:.|||::.:. |.:.....|||  ||..|..|  :::...|||..:.|...
Mouse   927 QLRDLIISEMQRLTKYPLLLENII-KHTAGGTSEYE--KLCRARDQCREILKFVNEAVKQTENRH 988

  Fly  1773 ELERIARQLEFPSHVRALAIAPVGVPRAG------AKPRFLVKRGELTHLLWRGEDAKLTFGKRL 1831
            .||...::|:      |.|:.....|.|.      ...|.::..|.||   ||....|       
Mouse   989 RLEGYQKRLD------ATALERASNPLAAEFKSLDLTTRKMIHEGPLT---WRISKDK------- 1037

  Fly  1832 TKISIYAFLFSDLLLLCKRRGE-------------SCFSVFDYCP---------RSMLT------ 1868
             .:.:...|..||::|.:|:.|             |..|...:.|         ||:.|      
Mouse  1038 -TLDLQVLLLEDLVVLLQRQEEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFF 1101

  Fly  1869 LAAGDSL--PQLPTKDLKDQAGKNLILMTLLENCDRKTVE-----LVLSCPS------------- 1913
            :.....|  ||:........:.|| |.|.|||...:...:     .||:.||             
Mouse  1102 IICTSELGPPQIYELVALTSSDKN-IWMELLEEAVQNATKHPGDAPVLNHPSPPGSQEPAYQGST 1165

  Fly  1914 -----VSDQQRWLQAMRPPE-AETPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRK 1972
                 |:|.:.:.....|.: :|.||.:  :.....|::|:...|.:| |..:|         |.
Mouse  1166 SSRVEVNDSEVYPTEREPKKPSEGPGPE--QRGQDKQLLAQEGPEQEE-DAEEL---------RA 1218

  Fly  1973 LP------DGWYQGERIRDGAVGWFPGSYTEE--LNSAHVRARNLKQRHRLL 2016
            ||      ||..:|.|.||..:....|....|  .::|.....||  ||.:|
Mouse  1219 LPCPPPSLDGENRGIRTRDPVLLALTGPLLMEGLADAALEDVENL--RHLIL 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 50/188 (27%)
PH_ephexin 1805..1931 CDD:269929 36/179 (20%)
SH3_ephexin1_like 1944..1998 CDD:212727 16/59 (27%)
Arhgef11XP_006501327.1 PDZ_signaling 62..136 CDD:238492 15/75 (20%)
RGS_PDZRhoGEF 346..490 CDD:188707 28/157 (18%)
RhoGEF 795..978 CDD:366202 50/189 (26%)
PH_PRG 996..1138 CDD:275426 34/159 (21%)
PHA03247 <1127..1469 CDD:223021 37/156 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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