Protein Alignment Exn and rhgf-2

DIOPT Version :9

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: NP_001368191.1
• Gene: rhgf-2 / 173748
• WormBaseID: WBGene00006476
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 1122
• Identity: 222/1122 - (19%)
• Similarity: 369/1122 - (32%)
• Gaps: 409/1122 - (36%)

  Fly  1048 ATT--DATANEAQFI---VVRERFKPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSP 1107
            |||  .|||..|.|:   .:||  :|...|..|                   .|||..:.|:.|.
 Worm    33 ATTLLAATACPAAFVDLDSIRE--EPPSPRPLD-------------------RDDSVFFRESCST 76

  Fly  1108 LGNKRHSTQLVRQSQDGNRSGGVRSSHRRSK-----NHSAS--AHTLGEHVVISDDYDSFETDSD 1165
            :|:.......:..|...:....:.|..|:.|     |.|:|  .:|............|.....|
 Worm    77 IGSPLDELPALPTSSTSSPFKFMESIQRKRKSMFRRNQSSSNLINTEKRRTTRRPSLPSIPPTID 141

  Fly  1166 D---------------HGDGEPDLRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRKFKDFISSK 1215
            :               |.|...:..|||    .:|.|.|.:...||   |:..|:..|||....:
 Worm   142 EMSSSVGHARSRRPSLHNDWTNEHAQRN----ALDNRIHHIDIDPP---QINYFIAVFKDLDDRE 199

  Fly  1216 KSPKGSQQKLYENTPASTLFYVECSKRTEDVYE-----------NTDFGPER--IPAPETKGPVH 1267
            |.   |.:.:          ..:|::...:|:|           :.:|..|:  .|.||..|
 Worm   200 KD---SVEHI----------RFDCNQLIYEVFEPFLRIRGLTINDVEFFLEKSSTPIPENSG--- 248

  Fly  1268 QEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALPLEPEIHG 1332
                    |:...|:.:..|.|.:          :..:..||:|..:::
 Worm   249 --------ARFLAGQRIFVRGRGN----------MKVVRHTRATHSMDE---------------- 279

  Fly  1333 SGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTGNKSPLDP 1397
            |.|             ..|.|.|..| .::|.:..|.|....|.|.:      |.:.|:..
 Worm   280 SNE-------------RATRKMSAEA-VSRKSSFVNSRILNRGSRNH------PGLNGSDD---- 320

  Fly  1398 ERELDAEQTTSWYAECGVFKQATNGAVSPRG----DEPVTPTPSGHGGVSSWYAESGLYQTSGIS 1458
                         |||    ::.:.::|.|.    |||........||...
 Worm   321 -------------AEC----RSNDSSLSVRDSWQYDEPSCSEVPDDGGTRR-------------- 354

  Fly  1459 VASSSGSSGVST--GNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEI 1521
             |.|..||.:|.  |.|.|   ::..|         ::::.:..|.::   |||.
 Worm   355 -ARSVTSSRISLFFGKETG---KIEKE---------MFRILNQKKEDT---DLEY---------- 393

  Fly  1522 GLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITS 1586
                                       |:..|..:..|::|:  ..:|:.:....|||.:||:|:
 Worm   394 ---------------------------PTYKLEKDWREIVHN--HESLSDKSIKQQEAIWEIVTT 429

  Fly  1587 EASYLKSLNLLRRHFMNHNAFLD-----SSVLSAKDRKALFSYIV---------------PV--- 1628
            |..|:|    |.|:..|.:.:|.     ..:...::|...|:::.               |:
 Worm   430 EFRYIK----LLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQSIEPILAK 490

  Fly  1629 -HECSERL-LTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESL 1691
             .|..|.| :..|:..::|   :...|||.     .:||:     .|...:....::||||:.
 Worm   491 SRETGEPLDVNYLQNGFRD---IENWSRCY-----TNFHL-----AHSDSLKHIQKKLKESEN-- 540

  Fly  1692 AFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQK 1756
             |:..:...||..:.....|.....:||||:||..||:.||....:..|..|..|..:..|  :.
 Worm   541 -FRDFVTWAEAQENLDRQKLIDTFSVPMQRLTRYNLLLKAVLKVTTDENEREMISNLVDCA--ES 602

  Fly  1757 VVGQCNEAANRWEQAFELERIARQLEFPSHV------RALAI---------APVGVPRAGAKPRF 1806
            ...|.|:..|..:....|..:.|.:|.|.:|      |...:         .|:..||   ||
 Worm   603 ATAQLNKELNNNDLRAMLGDVMRTIEGPDYVDQDELERLFNLKLPLNLGDFMPLLHPR---KP-- 662

  Fly  1807 LVKRGELTH--LLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKR----------------RGE 1853
                   ||  |::|| |.::..||:.:|..::..:|:|:.|:|::                .|:
 Worm   663 -------THRTLIYRG-DLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHMGK 719

  Fly  1854 SCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLS--CPSVSD 1916
            ..|..|                        .||.|..|:.:|     |..|.:.:.|  .....|
 Worm   720 MMFHYF------------------------ADQNGFYLVHLT-----DFHTAQALYSMHTSGPED 755

  Fly  1917 QQRWLQAMRPPEAETPGEKLY-ESWDCPQVVAKHSYESDEPDVLQLELGDVVNVS-----RKLPD 1975
            ..||...::....|.  :|:: :||.        .....|..:.:...|.::..|     |.||.
 Worm   756 TLRWTDMLKMALDEF--KKIHRDSWS--------QQNQQESPLDEYGRGFIMEPSSFYSQRMLPP 810

  Fly  1976 GWYQGE------------------------RIRDGAVGWFPGSYTEELNSAHVRARNLK---QRH 2013
            |:.|.:                        ..|..||     |.||:|: .|....::|   .||
 Worm   811 GYAQQQMPVIHRKCSSMDSQAVAAHAHLNYMHRSSAV-----SSTEQLD-RHSGTDSMKCSPPRH 869

  Fly  2014 RLLTFT--ATYLESQKS 2028
            :|...:  |..|.|.||
 Worm   870 KLSVASCHANPLSSSKS 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	47/206 (23%)
		PH_ephexin	1805..1931	CDD:269929	27/145 (19%)
		SH3_ephexin1_like	1944..1998	CDD:212727	13/82 (16%)
rhgf-2	NP_001368191.1	RBD_PLEKHG5	186..262	CDD:340588	18/99 (18%)
		RhoGEF	419..608	CDD:238091	50/210 (24%)
		PH_PLEKHG5_G6	665..765	CDD:270064	25/129 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910