DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Exn and ephx-1

DIOPT Version :9

Sequence 1:NP_001097630.2 Gene:Exn / 39900 FlyBaseID:FBgn0261547 Length:2029 Species:Drosophila melanogaster
Sequence 2:NP_494706.2 Gene:ephx-1 / 173742 WormBaseID:WBGene00019487 Length:1159 Species:Caenorhabditis elegans


Alignment Length:1375 Identity:357/1375 - (25%)
Similarity:543/1375 - (39%) Gaps:397/1375 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 KRAEKSPEKDDTLEP------------ESLYEPIT--------------PVMDETKTEAQ----- 780
            ||.|.|..:.:..:|            |:|:||.|              .:...|::.::     
 Worm    34 KRFETSTSRIEHHKPVISKRIGKFRVVENLHEPCTSRVLRGSAIPRRKSSLKRRTRSNSELAVLV 98

  Fly   781 TSSLFKIYTKKSELVEDIYQTVEEASTVEV------KPNNWLEGYESIAGS-------------- 825
            |||.|    :||:...|...|...||...:      .|...|:....|..|              
 Worm    99 TSSEF----RKSKSTGDFSPTGAGASGAPIVITPLPAPRLRLQTTSMIVESSPSPSFHSKKDGHP 159

  Fly   826 --QEACPLTYDGYESFAPEEVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAP-- 886
              :|.|.::.....|.:.:....:|..|             ||.:|..|..:.:.|..|:|.|  
 Worm   160 VYEERCRVSLTIPISSSEDLSAVSPPPP-------------LPSVPPSKERIKRIPSYLKPTPAP 211

  Fly   887 -------PKPQAKESEED---ENIYDTIKGCYESMHCKATSSSSSGEATL------TTDTISL-S 934
                   |:.:.|.....   .|.:||:...:.|   .:||||:.|...:      ....|.| .
 Worm   212 RSMSATLPRARLKTPPPPPPVTNQFDTLPVSFRS---SSTSSSTGGLPRIPNIPVPDVPFIPLDD 273

  Fly   935 SNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHKTNSLYESSLAAAGCVVYGS 999
            .|||:.|..:.            .|:.:||....     .:.|::    .|||.           
 Worm   274 DNCYDEIMLVT------------PSSNTCIPTHQ-----RLESEY----TYESQ----------- 306

  Fly  1000 ASVGCRSSLGSSAGSRDSGKPGDKRSSIAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVV-- 1062
                          |.|..:|...|:|  ||..||.......|.||.....:....|.:|..|  
 Worm   307 --------------STDFSRPEPPRAS--GSEPNSSRRAYPRDEEIFDEAEEELLEEQRFQKVPE 355

  Fly  1063 -RERF-KPHRTRSPDWSKRIRDKRLQQKKAISCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGN 1125
             :||| .....|:|..|||           :|.:|.:....:::...|...:..:|| ||..   
 Worm   356 IKERFLSSTLQRNPKSSKR-----------MSSMELEKLFRFKSELQLNLSKKVSQL-RQKV--- 405

  Fly  1126 RSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDS---------DDH--GD----GEPDLR 1175
               |.:.:.||||.|.:..       ::..|:.|..:.|         |||  ||    .:.|: 
 Worm   406 ---GDKQAKRRSKCHVSVD-------LLDTDFSSMMSKSSCVDKPFQDDDHIYGDDWSSDDDDI- 459

  Fly  1176 QRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRK-FKDFISSKKSPKGSQQKLYENTPASTLFYVEC 1239
               |:|   |.|:..       ..|:.|.:.| |.|::                          |
 Worm   460 ---YHD---DRRSSM-------YRQLEEQLNKAFPDYV--------------------------C 485

  Fly  1240 SKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSS 1304
            ..:....||:.|...:.|||                             |.|.|..| ||::   
 Worm   486 RSQLSSDYESADILVDPIPA-----------------------------RSSEVVMS-DTEK--- 517

  Fly  1305 LAPTRSTFYVEDPE-GSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKAN 1368
                    ||..|. |.||             ||..::..:...:.:.|         ..:.:..
 Worm   518 --------YVARPAVGHLP-------------LDDSWTPTSAEAIQDEP---------SPDEEEY 552

  Fly  1369 RRRTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPV- 1432
            :|:.|..:.||:.|.....|....:..|.|.::..|:..                     :||| 
 Worm   553 KRQYTCRMVPNEGPLYQHYMLEAVAVADDEVKIPLEEVK---------------------EEPVE 596

  Fly  1433 TPTPSGHGGVS---SWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLY 1494
            .|....|..|:   :...||.:...||.....|:.|:...|.|                      
 Worm   597 LPAAVVHEVVALKPATRRESSISSDSGRGADCSTTSASALTSN---------------------- 639

  Fly  1495 QMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKN-GPSRTLWSEIP 1558
                    .|:.||                                :||...| |..|:||.|:|
 Worm   640 --------TSMRRD--------------------------------RLVGTSNFGSQRSLWCELP 664

  Fly  1559 EVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDS----SVLSAKDRK 1619
            ||..:.:|..|....:..|||.||:||||||||:|||:|..|||.....|.|    ||||..|||
 Worm   665 EVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRK 729

  Fly  1620 ALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRL 1684
            .|||.|..|.:||||||.:||...::|::|..:...:.:..::||.||:.:|.:|...|||||||
 Worm   730 HLFSNIFAVRDCSERLLCDLETRLEENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRL 794

  Fly  1685 KESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKL 1749
            |  .|:..|...::|||.:..|.||::.|||||||||:||.|||:.|:..:.:..: :.|::...
 Worm   795 K--TENPGFLSAVQRLEENKQCQGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTD-DRYKTATD 856

  Fly  1750 TLALVQKVVGQCNEAANRWEQAFELERIARQLEF-PSHVRALAIAPVGVPRAGAKPRFLVKRGEL 1813
            .|....:||..|||.|.|.|:..:|..|.|:|.: .:.::.:.:.        :..|:|||:|.|
 Worm   857 ALTSSNRVVRDCNEGARRMERTEQLLDIDRRLIYKDADLKRIPLV--------SNSRYLVKKGVL 913

  Fly  1814 THLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGD-SLPQ 1877
            |.|:.|.....|.  .|....:::.|||||::::.|::....|...||..|..:.:...: ..|:
 Worm   914 TQLVERRSSNILQ--SRQKARTLHVFLFSDMIMITKKKLNGTFVCKDYAARRFVDMQPIEPDNPK 976

  Fly  1878 LPTKDLKDQAGK-NLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWD 1941
            :|.....:..|: :|.|.||:.|...|..||:||..|.:|::|||.|:|||.:..|.||:|..||
 Worm   977 IPLGATSNLVGRPHLFLCTLMRNARDKQTELLLSADSETDRERWLSAVRPPTSTNPEEKIYAEWD 1041

  Fly  1942 CPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSYTEELNSAHVRA 2006
            |||.:..|:|:..:.|.|||.:||.:|:.||:||||..|||..||..||||.||.:.:.:.|.||
 Worm  1042 CPQALVVHAYQPSQADELQLNIGDSLNILRKMPDGWLYGERAGDGLGGWFPSSYVQAIINDHTRA 1106

  Fly  2007 RNLKQRHRLL 2016
            .|.:||.|::
 Worm  1107 NNYRQRLRII 1116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ExnNP_001097630.2 RhoGEF 1581..1763 CDD:279015 83/185 (45%)
PH_ephexin 1805..1931 CDD:269929 43/127 (34%)
SH3_ephexin1_like 1944..1998 CDD:212727 27/53 (51%)
ephx-1NP_494706.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 145 1.000 Domainoid score I2840
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4837
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001805
OrthoInspector 1 1.000 - - oto20378
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12845
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 1 1.000 - - X1705
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.990

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