DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Arhgef1

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_006539628.1	Gene:	Arhgef1 / 16801	MGIID:	1353510	Length:	980	Species:	Mus musculus

Alignment Length:	955	Identity:	205/955 - (21%)
Similarity:	314/955 - (32%)	Gaps:	304/955 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1116 QLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETD---SDDHGDGEPDLRQR 1177
            :|...|:|.|..   ..|..:.|...|....|.:||.:     .||..   ...|.|....|..:
Mouse    32 ELEANSEDQNSQ---FQSLEQVKRRPAHLMALLQHVAL-----QFEPGPLLCCLHADMLSSLGPK 88

  Fly  1178 NYNDSGVDMRNHRLPKP-----PPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYV 1237
            ....:.:|..:..|.|.     |.|.:..:|..|...|.||
Mouse    89 EAKKAFLDFYHSFLEKTAVLRVPVPPSVAFELDRTRPDLIS------------------------ 129

  Fly  1238 ECSKRTEDVYENTDFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQL 1302
                  |||...  |..|         .|..:||.|.|..:    ..||   |.|:|.:...::|
Mouse   130 ------EDVQRR--FIQE---------VVQSQQAAVSRQLE----DFRS---KRLMGMTPWEQEL 170

  Fly  1303 SSLAPTRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTV---------- 1357
            |.|.|     ::....|:..|    .|.|.:..|.|...:...|...:..|.:.|
Mouse   171 SLLEP-----WIGKDRGNYEA----RERHVAERLLSHLEETQHTISTDEEKSAAVVTAISLYMRH 226

  Fly  1358 --ARKAKKEAKANR---RRTTIGLRPNDPPPPPPPMTGNKSPLDPER----------------EL 1401
              .|....:.|:.|   |:..:|.|.:|  .||....|..|.|||.|                |.
Mouse   227 LGVRTKSGDKKSGRNFFRKKVMGNRRSD--EPPKTKKGLSSILDPARWNRGEPSAPDCRHLKVEA 289

  Fly  1402 DAEQTTSWYAECGVFKQATNGAV-SPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGS 1465
            |||:......:.|:...:.:..| :|..|.|         |||       |:..|..||  .|..
Mouse   290 DAEKPGPADRKGGLGMSSRDRTVGTPGQDNP---------GVS-------LHPLSTDSV--DSRE 336

  Fly  1466 SGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSA-----------------AKLESI-------- 1505
            .||.|..|.|     .:.|....|.|||....|.                 .:.||:
Mouse   337 PGVDTPQEPG-----DTPPQGPTSLEPLAPPESTEDNGETERRWKRLSGRLGRSESLRVSDRRRP 396

  Fly  1506 -TRDLEAHGSSDGYEE-------------IGLQAKAKPEP--LVKPRPTALQLVEPKNGPSRTLW 1554
             ...|.|.|...|...             :|...:|.|||  ..:|..:.|:| ||:..|.   |
Mouse   397 SRGSLGAKGRGGGRSRSDVDMDPGSATAVLGPTRRATPEPGDDGEPGRSGLEL-EPEEPPG---W 457

  Fly  1555 SEI--PEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMN-------------- 1603
            .|:  |:.:.|     |...:...||...|::.:||::::.|.:|...|..
Mouse   458 RELVPPDTLLS-----LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFYQPMADGGFFPLDELQ 517

  Fly  1604 ------------HNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTEL---EACWQDNIMLLGLS 1653
                        |:.|||..:    .|:....|:  :.|..:.||...   |..|
Mouse   518 NIFPSLDELIEVHSLFLDRLM----KRRQESGYL--IEEIGDVLLARFDGAEGSW---------- 566

  Fly  1654 RCIYEIAERHFHVYVAFCEHQGRMDRTLRRLK-ESKESLAFQQHLERLEASPSCCGLNLHSFLML 1717
              ..:|:.|       ||   .|....|.:|| :.::...|...::..|:.|.|..|.|...:..
Mouse   567 --FQKISSR-------FC---SRQSFALEQLKAKQRKEPRFCAFVQEAESRPRCRRLQLKDMIPT 619

  Fly  1718 PMQRITRLPLLIDAVFSKESPLNREEYESWKLTLA--LVQKVVGQCNEAANRWEQAFELERIARQ 1780
            .|||:|:.|||:.::...    ..|..|..|:.||  ..::::...|:|....|....|:...|:
Mouse   620 EMQRLTKYPLLLQSIGQN----TEESTERGKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRR 680

  Fly  1781 LEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTK---ISIYAFLFS 1842
            |:. :|:|..:     .|.........:.:.:|.|      :..||:  |:||   |.::..|..
Mouse   681 LDL-THLRQSS-----DPMLSEFKNLDITKKKLVH------EGPLTW--RVTKDKAIEVHVLLLD 731

  Fly  1843 DLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLKDQAGKNLI--------LMTLLEN 1899
            |||||.:|:.|.             .|....|....||.|     ||.::        .||....
Mouse   732 DLLLLLQRQDER-------------LLLKSHSRTLTPTPD-----GKTMLRPVLRLTSAMTREVA 778

  Fly  1900 CDRKTVELV-----------LSCPSVSDQQRWLQAMRPPEAETPG 1933
            .|.|...::           |...:.|:::.|...:    .||.|
Mouse   779 TDHKAFYVIFTWDQEAQIYELVAQTSSERKNWCNLI----TETAG 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	43/213 (20%)
		PH_ephexin	1805..1931	CDD:269929	30/147 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Arhgef1	XP_006539628.1	RGS_p115RhoGEF	50..242	CDD:188709	51/253 (20%)
		PHA03247	<277..462	CDD:223021	47/211 (22%)
		RhoGEF	479..663	CDD:214619	43/215 (20%)
		PH_p115RhoGEF	697..821	CDD:275429	33/153 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900