DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and Arhgef2

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_006501121.1	Gene:	Arhgef2 / 16800	MGIID:	103264	Length:	1185	Species:	Mus musculus

Alignment Length:	901	Identity:	193/901 - (21%)
Similarity:	307/901 - (34%)	Gaps:	267/901 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1120 QSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGV 1184
            ::|:.|:.|...|..|||....|.::|.          |||:..|  .|.|      :.:.|
Mouse    42 ENQEDNKDGFHTSLLRRSGAFRARSYTT----------DSFKRHS--WGPG------KEFQD--- 85

  Fly  1185 DMRNHRLPKPPPPQNQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYEN 1249
            .:...||.....|.:|...|::..::.    .:|.|:||:..:.
Mouse    86 PISRRRLQSSECPGSQEAPFLQSLEEL----GTPLGAQQQEQQQ--------------------- 125

  Fly  1250 TDFGPERIPAPETKG-PVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFY 1313
               |.|     :.:| |.|:.|:....:...:..|:...|.|::  |..|...||..:
Mouse   126 ---GQE-----QQRGQPFHRGQSFCYPSAASSVPSVTGMLSKAV--SMSDINLLSDCS------- 173

  Fly  1314 VEDPEGSLPALPLEPEIHGSG---ELDSG----------FSDKNCTPLPETPKFSTVARKAKKEA 1365
              ||.|:.|. ....::...|   |.|||          ||    ..|..|.:..|..::..|||
Mouse   174 --DPNGNSPQ-SYVTDLSKCGKQLEEDSGTWAGSSLRRTFS----FLLGMTGRDKTREKEKMKEA 231

  Fly  1366 KANRRR-----TTIGLRPNDPPPPPPPMT----GNKSPLDPERELDA-------EQTTSWYAECG 1414
            |..|..     |||.:         ..||    .|||....|..:..       .:.....|.|.
Mouse   232 KDARYTNGHLFTTISV---------SGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCT 287

  Fly  1415 VFKQATNGA-----------VSPRGDEPVTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGV 1468
            ..||....|           ||.|........|:.....|..:.:|.|....|:|  |.|.:..|
Mouse   288 KVKQKQQKAALLRNNTALQSVSLRSKTTTRERPTSAIYPSDSFRQSLLGSRRGLS--SLSLAKSV 350

  Fly  1469 STGNEAG-LGDE--------LSSEPHSL-------------------FSNEPLYQMYSAAKLESI 1505
            ||.|.|| ..||        ||....||                   |.||.:      :..|..
Mouse   351 STTNIAGHFNDESPLGLRQILSQSTDSLNMRNRTLSVESLIDEGVEVFYNELM------SDFEMD 409

  Fly  1506 TRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLT 1570
            .:|.||...|...:...||...|                              ||:..
Mouse   410 EKDFEADSWSLAVDSSFLQQHKK------------------------------EVMKK------- 437

  Fly  1571 SRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERL 1635
                  |:..:|:|.:|..::::|.::.|.|  ....|:...:..:..:.||..:..:.:...|.
Mouse   438 ------QDVIYELIQTELHHVRTLKIMTRLF--RTGMLEELQMEPEVVQGLFPCVDELSDIHTRF 494

  Fly  1636 LTEL-----EACWQDN-----IMLLG---LSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKES 1687
            |.:|     :|....:     |..||   :|:.....||:....|..||      .|..:.||..
Mouse   495 LNQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGSNAEQMRKTYSEFC------SRHTKALKLY 553

  Fly  1688 KESLA----FQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWK 1748
            ||..|    |||.:.::..|.......:...::|..||||:.|:||:.:......: .|||:...
Mouse   554 KELYARDKRFQQFIRKMTRSAVLKRHGVQECILLVTQRITKYPVLINRILQNSHGV-EEEYQDLA 617

  Fly  1749 LTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGEL 1813
            ..|.||::::      :|..:...|||:.||..|..:.:...|..|  ||..|...|..:.|.:|
Mouse   618 SALGLVKELL------SNVDQDVHELEKEARLQEIYNRMDPRAQTP--VPGKGPFGRDELLRRKL 674

  Fly  1814 TH---LLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSL 1875
            .|   |||:....:..        .:...|.:|:|:..:.:.:.  .:|....:..:.     ||
Mouse   675 IHEGCLLWKTATGRFK--------DVLLLLMTDVLVFLQEKDQK--YIFTSLDKPSVV-----SL 724

  Fly  1876 PQLPTKDLKDQAGKNLILMT----------LLENCDRKT-----VELVLSCPSVSD 1916
            ..|..:|:.:|| |.:.|::          .....||.|     .:.|..|||..|
Mouse   725 QNLIVRDIANQA-KGMFLISSGPPEMYEVHAASRDDRTTWIRVIQQSVRLCPSRED 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	46/198 (23%)
		PH_ephexin	1805..1931	CDD:269929	27/130 (21%)
		SH3_ephexin1_like	1944..1998	CDD:212727
Arhgef2	XP_006501121.1	C1	240..285	CDD:237996	9/53 (17%)
		RhoGEF	437..631	CDD:238091	48/221 (22%)
		PH_ARHGEF2	671..786	CDD:275428	26/125 (21%)
		TIGR02680	<1000..>1072	CDD:274256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810