DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Arhgef5

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_038964580.1	Gene:	Arhgef5 / 140898	RGDID:	620718	Length:	1589	Species:	Rattus norvegicus

Alignment Length:	1786	Identity:	407/1786 - (22%)
Similarity:	681/1786 - (38%)	Gaps:	441/1786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 PRIKRNLKLPPG---SVGIPELAIVSEELKTPTSE---------EQAKKPKSVQNESQPNHPEEL 522
            |.|:....:|.|   |..||.|...::|.:.|:.:         :|:|..:.|.:.:..:.....
  Rat    15 PDIEELGAIPEGIMRSSQIPALDPEAQEGQDPSYKWTDGHRSLMDQSKVLRDVSDHTPNSVAIFF 79

  Fly   523 NQSNDKPSDELDLIMGEEGDEEELRQKQRKHKYASIYEKLRFTFAKGR-------------KSAS 574
            .:.:...:...::::.|..|..:    |::....|:.::|..|.|...             .|..
  Rat    80 KKDSSAMATSQEILLAEARDTAD----QQEAVTQSLQDRLSTTVAAPELLGCAVQEEWLDIPSKL 140

  Fly   575 PSPTKAQIREE-----VSIDEESIKDSTSEDMVT-----------RKEDFTLDLPKEVIPRAEDL 623
            .|..:|:::.|     :::.:|..::.:|.|..|           .:.|.|.....|::.:.:.|
  Rat   141 DSRVEAELQPELMSLTLAVSKEKEEEESSPDTSTPGFWPPSKIHPGETDQTEGSGMELLRQGKQL 205

  Fly   624 ------EDSSHALLVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTADGERELLLAANDDFEQR 682
                  |:.....|:.|   .:|:.|:..|..:::::....|.:.....|    ||....:.|:.
  Rat   206 QLEATQENRGQQGLLQP---QEAQGLEEQEGQEVEIQEEGTLREDICFGG----LLGEQKEVEED 263

  Fly   683 ILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEG---EQMIMEQKQLMKVRDLELTERDIDQ 744
            ...|..   :...:|..:..:|..|..:..|...:||   .:...|:::.......:..|...||
  Rat   264 FNDNKE---EQKQEQIQSYMLLGGQWESEGLSGELEGLNYNERSQEERERRVCGQRDSKEEGQDQ 325

  Fly   745 PLKRAEKSPEKDDTLEPESLYEPITPVMDETKTEAQTSSLFKIYTKKSELVEDIYQTVEEASTVE 809
            .|:..|:........|.:.|.|....|....:...|......:..:|           |...:.:
  Rat   326 ELREVEERRVGTQCAENQMLEEISENVRRRQEDHDQAGQAMHVGDQK-----------EVVDSGD 379

  Fly   810 VKPNNWLEGYESI-------AGSQEACPLTYDGYESFAPEEVVTTPTT-----PSATGTLGRNTR 862
            .:...|..|.::.       ..::...|:|     |.||.  |.:|.|     ||:...:.:..|
  Rat   380 REQGTWDSGGQAAEERSRTGEDNKPCLPMT-----SIAPG--VLSPGTLFPAIPSSVDDMSQIQR 437

  Fly   863 DELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGCYESMHCKATSSSSSGEATLT 927
            :     |.|:.:..::|.|    .|:|..                :...|....:|.::.||
  Rat   438 E-----PVPEELTTQAPTP----APEPTE----------------WSHQHISPPASFATEEA--- 474

  Fly   928 TDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSG--------------STLTISSD 978
                 |.:..::|.....:.|..|..|||..:..:.|.::.||              :|.|.|..
  Rat   475 -----LDNRTHDSQQEEFKLRKGTISNQGTENVSASISVAPSGTPDLPPFTPPNVFPTTATFSLV 534

  Fly   979 HKTNSLYESSLAAAGCVVYGSASVG-CRS------SLGSSAGSRDSGKPGDKRSSIAGSSDNSDA 1036
            ..:..|.|....||......|...| |.:      |......:.|:..|....:|..|.:.:
  Rat   535 SSSVILPEKETPAASISADISPHYGPCETPPLPAKSTRDPCATSDTANPHSPLTSYTGVTQH--- 596

  Fly  1037 WVDISDGEIGQATTDATANEAQFIVVRERFKP--HRT-RSPD---WSKRIRDKRLQQKKAISCIE 1095
                                     :|....|  ||| ::||   .|.......|.|:...:.|
  Rat   597 -------------------------LRSNSFPGSHRTEQTPDSMGMSLSFSHLELPQRPPKTAI- 635

  Fly  1096 DDSDHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDDYDSF 1160
                  |.:|.|..|:|            :|.|.|.|      ..||:...|.:.   |:::.|.
  Rat   636 ------YGSLIPRRNRR------------SRDGVVFS------ESSAALFALKQD---SEEFTSN 673

  Fly  1161 -ETDSDDHGD---GEPDLRQRNYNDS---------------GVDMRNHRLPKPPPPQNQVYEFVR 1206
             |:.|:.||.   |.|.      |.:               .:||.:..||.|||.:...|..:.
  Rat   674 PESSSNPHGSQPWGSPQ------NSAFAIGSPVNVSSPPTVSMDMIHEALPPPPPEKRHSYSHIV 732

  Fly  1207 K----FKDFISSKK----------------SPKGS-----------QQKLYENTPASTLFYVECS 1240
            :    |.:..::.|                |||||           |.:...:||       |.|
  Rat   733 ERDGLFHEVAATLKRHSHPPPLTLSSGLHRSPKGSFSLVPDSVVARQHRPLPSTP-------EGS 790

  Fly  1241 KRTEDVYENTDFGPERI-------PAPETKGPVH------------------------QEQAPVL 1274
            ..|:...      |.|:       |.|:...|.|                        .|..|:.
  Rat   791 HHTQTSI------PSRLRYNKPLPPTPDMPEPCHSSISSSNISRIYRPLPPVPITDPSSEPPPLP 849

  Fly  1275 RAKQKNGKSLRSRLRKSL-------VGSSFDTKQLS---------------SLAPTRSTFYVEDP 1317
            ...::..:|::..:..|:       .|..:....||               ||.||........|
  Rat   850 PKSRERSRSVQVGVMHSMGQANPRTTGQDWTVSTLSVGRTSWPPATGRSTESLPPTSRCNSEVSP 914

  Fly  1318 -----------EGSLPALPLEPEIH-GSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRR 1370
                       ..|.|..|..||:. .:.:.:||.::::..|:.     .:..|.|.:|...|.|
  Rat   915 GLAFSNMTNLLSPSSPTTPWSPELQIPTSKDESGLTEESAPPVR-----GSFRRPALQEEFNNTR 974

  Fly  1371 RTTIGLRPNDPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPT 1435
            |:.:|.|.....|....:  .|:...|.|. |..:|:...:|..|..||.|   ..:|
  Rat   975 RSALGSRKKSEKPIHYQL--EKASSWPHRR-DTARTSESSSEQVVLGQAPN---KQKG------- 1026

  Fly  1436 PSGHGGVSSWYAESGLYQTSGISVASSSGSSGVSTGNEAGLGDEL---SSEPHS----------- 1486
                     |..: ||.:.| |...|||.....:.|...|..|.:   ..:|..
  Rat  1027 ---------WNRQ-GLRRPS-ILPESSSDLRNPAAGRLPGSSDSVVFREKKPKEGMGGFSRRCSK 1080

  Fly  1487 -LFSNEPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKN--- 1547
             :.|::.|||.||...|   .:::::        :..|.:.|:|..:..||.....||...:
  Rat  1081 LINSSQLLYQEYSDVVL---NKEIQS--------QQRLDSLAEPPGISSPRYRRKALVSSDSYLQ 1134

  Fly  1548 ----GPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFL 1608
                ..|.:||.|||.|.:|.:|.::|..::.|||||||:|.||||||:|||:...|| .|:..|
  Rat  1135 RLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEAKFELIVSEASYLRSLNIAVDHF-QHSTQL 1198

  Fly  1609 DSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEH 1673
             .:.||.:|.:.|||.:..|.:.|...|::||..:::||....:...:.:.|.....||:.:..:
  Rat  1199 -RATLSNQDHQWLFSRLQDVRDVSTTFLSDLEENFENNIFSFQVCDVVLDHAPDFHRVYLPYVTN 1262

  Fly  1674 QGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESP 1738
            |...:||.:.|..|..|  |::.||:||:.|.|..|:|.|||:||.||||||.||:..:..:..|
  Rat  1263 QTYQERTFQSLMNSNSS--FREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQP 1325

  Fly  1739 LNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAK 1803
            .:.||.|:.|...|| :|::..||....|..:..||..:::::||...:..|.          ::
  Rat  1326 GSSEEAEATKAHHAL-EKLIRDCNSNVQRMRRTEELIYLSQKIEFECKIFPLI----------SQ 1379

  Fly  1804 PRFLVKRGELTHLLWRGEDAKLTFG--KRLTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSM 1866
            .|:|||.||||.|     :..::.|  ::||...::..||:|.|||.:.|..|.|.|||:.|.|.
  Rat  1380 SRWLVKSGELTAL-----EFSVSPGLKRKLTTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSS 1439

  Fly  1867 LTLAAGDSLPQLPTKDLK-DQAGKNLILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAE 1930
            :   .|:..      ::| ..|.|||..:.||.|......|.:....:.|::.||:.|:..|..|
  Rat  1440 I---RGEKC------EMKLHGAHKNLFRLFLLHNAQGTQAEFLFRTETQSEKLRWISALAMPREE 1495

  Fly  1931 TPGEKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAVGWFPGSY 1995
            .   .|.|.:|.|||....:|:..|.|.|.||..|||.|:::..|||.:|.|:.||..||||...
  Rat  1496 L---DLLECYDSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGEQGWFPLQQ 1557

  Fly  1996 TEELNSAHVRARNLKQRHRLLTFTATYLESQ 2026
            .|.:::..||.:|||:.||:.|.....:|.|
  Rat  1558 VEFISNPEVRVQNLKEAHRVKTAKLQLVEQQ 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	69/181 (38%)
		PH_ephexin	1805..1931	CDD:269929	41/128 (32%)
		SH3_ephexin1_like	1944..1998	CDD:212727	23/53 (43%)
Arhgef5	XP_038964580.1	ARHGEF5_35	1..478	CDD:406010	87/527 (17%)
		PHA03247	<395..840	CDD:223021	105/559 (19%)
		RhoGEF	1172..1348	CDD:395496	68/180 (38%)
		PH_ephexin	1370..1496	CDD:269929	42/149 (28%)
		SH3_ARHGEF5_19	1506..1560	CDD:212873	23/53 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5800
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45587
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12845
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010