DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and FGD4

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	NP_001357227.2	Gene:	FGD4 / 121512	HGNCID:	19125	Length:	903	Species:	Homo sapiens

Alignment Length:	752	Identity:	152/752 - (20%)
Similarity:	264/752 - (35%)	Gaps:	197/752 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1334 GELDSGFS-DKNCTPLPETPKFST----------VARKAKKEAKANRRRTTIGLRPNDPPPPPPP 1387
            |::.||.: ...|..:...|..||          |:.:..:....||........|. |..||.|
Human    48 GQVPSGATGSSTCPKIALVPPCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPK-PQVPPKP 111

  Fly  1388 MTGNKSPLDPERELDAEQTTSWYA------ECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWY 1446
            :....||     ..:..||....|      .....|.|:...||......|:...|...|.||..
Human   112 LHLQNSP-----SSNIHQTPRHKALPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGGSSLS 171

  Fly  1447 AESGLYQTSGISVAS--SSGSSGVST---------------GN---------------------- 1472
            ..|.|.:.|.:::.:  :.|..|::|               ||
Human   172 NYSDLKKESAVNLNAPRTPGRHGLTTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQ 236

  Fly  1473 ---EAGLGDELSSEPHSLFSNEPLYQMY---------SAAKLESITRDLEAHGSSDGY------- 1518
               |......|||:. |:.::|||...:         :.|.....|...:.:.|...|
Human   237 MECEEEKAATLSSDT-SIQASEPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGP 300

  Fly  1519 ----EEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEA 1579
                ||.|.:.:.|.:             |.:||.|.....::.:  |..:..|   .|:.|.:.
Human   301 VLPLEERGAETETKVQ-------------ERENGESPLELEQLDQ--HHEMKET---NEQKLHKI 347

  Fly  1580 KFEIITSEASYLKSLNLLRRHF-------MNHNAFLDSSVLSAKDRKALFSYIVPVHEC-SERLL 1636
            ..|::.:|.:|:..|:||.:.|       .|..:|      .|:....:||.|..::.. |:.||
Human   348 ANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF------PAEMVNKIFSNISSINAFHSKFLL 406

  Fly  1637 TELEACWQDNIMLLGLSRCIYEIAERHFHVYVAFCEHQGRMDRTLRRLKESKESL-AFQQHLERL 1700
            .|||...|:    ...:..|.:|.::.......:.|:....|..:..:|...|.: .|:..:|.:
Human   407 PELEKRMQE----WETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEI 467

  Fly  1701 EASPSCCGLNLHSFLMLPMQRITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAA 1765
            :....|..|.|...::.|:|||.|..:|:.. :.::.|.:..::...|.:|.::.......|.|.
Human   468 QKQKICGSLTLQHHMLEPVQRIPRYEMLLKD-YLRKLPPDSLDWNDAKKSLEIISTAASHSNSAI 531

  Fly  1766 NRWEQAFELERIARQLEFPSHVRALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKR 1830
            .:.|...:|..|...|.....:    :.|         ...|:|.|::..|..|...|:
Human   532 RKMENLKKLLEIYEMLGEEEDI----VNP---------SNELIKEGQILKLAARNTSAQ------ 577

  Fly  1831 LTKISIYAFLFSDLLLLCKRRGESCFSVFDYCPRSMLTLAAGDSLPQLPTKDLK-----DQAGKN 1890
                ..|.|||:::||.|..:.....|.|     ::.|....|.:..:.|::.:     ..:||
Human   578 ----ERYLFLFNNMLLYCVPKFSLVGSKF-----TVRTRVGIDGMKIVETQNEEYPHTFQVSGK- 632

  Fly  1891 LILMTLLENCDRKTVELVLSCPSVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAK----HSY 1951
                       .:|:||..|  |..|::.|::|::  |......:.:|::  ...:||    ||
Human   633 -----------ERTLELQAS--SAQDKEEWIKALQ--ETIDAFHQRHETF--RNAIAKDNDIHS- 679

  Fly  1952 ESDEPDVLQLELGDVVNVSRKLPDGWYQGERIRDGAV 1988
                 :|...|||       |....|     |||..|
Human   680 -----EVSTAELG-------KRAPRW-----IRDNEV 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	40/190 (21%)
		PH_ephexin	1805..1931	CDD:269929	29/130 (22%)
		SH3_ephexin1_like	1944..1998	CDD:212727	14/49 (29%)
FGD4	NP_001357227.2	RhoGEF	344..528	CDD:238091	41/194 (21%)
		PH1_FDG4	560..653	CDD:275434	27/121 (22%)
		FYVE_FGD1_2_4	691..755	CDD:277280	5/14 (36%)
		PH2_FGD1-4	774..876	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810