DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and Arhgef28

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_006517581.1	Gene:	Arhgef28 / 110596	MGIID:	1346016	Length:	1714	Species:	Mus musculus

Alignment Length:	1509	Identity:	272/1509 - (18%)
Similarity:	481/1509 - (31%)	Gaps:	498/1509 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 VTRKEDFTLDLPKEVIPRAEDLEDSSHALLVSPCFEADAKILDALEAVDLKLKVLNPLNDVTTAD 666
            ||..::....|.:.::.:|:.|...||..|::|.    |..::||.|:|
Mouse   103 VTYVDNMACRLARLLVTQADRLTACSHQTLLTPF----ALTVEALPALD---------------- 147

  Fly   667 GERELLLAAND---DFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTL------VNAIEGEQM 722
              .||:||...   .....:|.|||.....      :.:.||:.||...|      :..:.|
Mouse   148 --EELVLALTQLELPLGWTVLGNSSLEVSL------HRESLLHLAVRWALPKLFHFLLCLPG--- 201

  Fly   723 IMEQKQLMKVRDLELTERDIDQPLKRAEKSPEKDDTLEPESLYEPIT-------PVMDETKTEAQ 780
                    .|:.|:|...:...||..|.:...       .:|.|.||       |.....:...:
Mouse   202 --------GVKALKLPNEEATTPLDLALQGGH-------STLVEDITNFQGSHSPGFSRLRLNEE 251

  Fly   781 TSSLFKIYTKKSELVEDIYQTVEEASTVEVK---PNNWLEGYESIAGSQEACPLTYDGYESFAPE 842
            .:..| :::.:: |...:..|.|.....::|   ...|...:...|..||            |..
Mouse   252 ATLQF-VHSSET-LTLTVNHTAEHLLEADIKLFRKYFWDRAFLVKALEQE------------AKT 302

  Fly   843 EVVTTPTTPSATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKGC 907
            |..|.|:..:.|....||...            .:||           ::|.|:.::|...:.|
Mouse   303 EKATMPSGAAETEEEVRNLES------------GRSP-----------SEEEEDAKSIKSQVDG- 343

  Fly   908 YESMHCKATSSSSSGEATLTTDTISLSSNCYESISHIRRS----RVATTQNQGHGSAGSCIQLSS 968
                     .|....:..|..|.   |.:..:...|:..|    :::...|.|.....:|:.:..
Mouse   344 ---------PSEHEDQDRLPLDR---SFDGLKKSKHVPASLAAGQLSDVLNGGDEVYANCMVIDQ 396

  Fly   969 SGSTLTISSDHKTNSLYESSLAAAGCVVYGSASVGCRSSLGSSA-------GSRDSGKPGDKRSS 1026
            .|            .|..:.:...|...:.|...| ||.||..|       .:...|:|
Mouse   397 VG------------DLDINYINLEGLSTHTSPESG-RSMLGPQACMHTLPPDTSPCGRP------ 442

  Fly  1027 IAGSSDNSDAWVDISDGEIGQATTDATANEAQFIVVRERFKPHRTRSPDWSKRIRDKRLQQKKAI 1091
                      .::.|:|     |.||.|::: |:            :|..|   |...|.....:
Mouse   443 ----------LIENSEG-----TLDAAASQS-FV------------TPSSS---RTSNLNLSFGL 476

  Fly  1092 SCIEDDSDHYYETLSPLGNKRHSTQLVRQSQDGNRSGGVRSSHRRSKNHSASAHTLGEHVVISDD 1156
            ...|.:..|.         |:.|:.|.....|....||.......:....:|..|   .:...|:
Mouse   477 HGFEKEQSHL---------KKRSSSLDALVADSEGEGGSEPPICYAVGSQSSPRT---GLPSGDE 529

  Fly  1157 YDSFETDSDDHGDGEPD--------------LRQRNYNDSGVDMRNHRLPKPPPPQNQVYEFVRK 1207
            .|||||::      |||              |..:....||:..|::....|.....:    .|.
Mouse   530 LDSFETNT------EPDCNISRTESLSLSSTLHSKESLLSGIRSRSYSCSSPKISSGK----SRL 584

  Fly  1208 FKDFISSKKSPKGSQQKLY--ENTPASTLF-------YVECSKRTEDVYE---NTDFGPERIPAP 1260
            .:||.....|   .:|:.|  :..|.....       ||..:|...:.|:   ...|...|:.:|
Mouse   585 VRDFTVCSTS---EEQRSYSFQEPPGEKRIQEEEWDEYVIPAKSESEKYKVSRTFSFLMNRMTSP 646

  Fly  1261 ETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQLSSLAPTRSTFYVEDPEGSLPALP 1325
            ..|            :|.||.                |||:...:  .|..|......|.|....
Mouse   647 RNK------------SKMKNK----------------DTKEKEKM--NRHQFVPGTFSGVLQCSG 681

  Fly  1326 LEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKEAKANRRRTTIGLRPNDPPPPPPPMTG 1390
            .:..:.|...|...    ||                    |||..:   |.:...||
Mouse   682 CDKTLLGKESLQCA----NC--------------------KANTHK---GCKDAVPP-------- 711

  Fly  1391 NKSPLDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPVTPTPSGHGGVSSWYAESGLYQTS 1455
                           .|..:.|    |...|...|..|...|...|:                 .
Mouse   712 ---------------CTKKFQE----KYNKNKPQSILGSSSVRDVPA-----------------P 740

  Fly  1456 GISV-ASSSGSSGVSTGNEAGLGDELSSEPHSLFSNEPLYQMYSAAKLESITR---DLEAHGSSD 1516
            |:|: .|||...|:..|.:     |.:::.|      ||.:......|||..|   .||:.|.|
Mouse   741 GLSLHPSSSMPIGLPAGRK-----EFAAQVH------PLSRSVPGTTLESFRRAVTSLESEGDS- 793

  Fly  1517 GYEEIGLQAKAKPEPLVK-----PRPTALQLVEPKNGPSRTLWSEI--------PEVIHSCILPT 1568
                  .::::..:.|.:     |...:..:.:..:.   :||.::        .|.....:.|:
Mouse   794 ------WRSRSHSDELFQSMGSSPSTESFMMEDVVDS---SLWIDLSSDAQEFEAESWSLVVDPS 849

  Fly  1569 LTSRER----SLQEAKFEIITSEASYLKSLNLLRRHF---MNHNAFLDSSVLSAKDRKALFSYIV 1626
            ..||:.    ..|:..||::.:|..::::|.::...|   |.....||.|.:.
Mouse   850 FCSRQEKDVIKRQDVIFELMQTEVHHIQTLLIMSEVFRKGMKEELQLDHSTVD------------ 902

  Fly  1627 PVHECSERLL------------TELEACWQDN----IMLLG---LSRCIYEIAERHFHVYVAFCE 1672
            .:..|.:.||            ...|:|...:    |..:|   :.:...|.|.:...:|..||.
Mouse   903 KIFPCLDELLETHRHFFFSMKERRQESCAGSDRNFVINQIGDILVQQFSEENASKMKRIYGEFCS 967

  Fly  1673 HQGRMDRTLRRLKESKESLAFQQH--------LERLEASPSCCGLNLHSFLMLPMQRITRLPLLI 1729
            |........:.|:::|:   ||..        |.|....|.|        ::|..||||:.|:|:
Mouse   968 HHKEAMSLFKELQQNKK---FQNFIKIRNSNLLARRRGIPEC--------ILLVTQRITKYPVLV 1021

  Fly  1730 DAV--FSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAI 1792
            :.:  ::||   ..||:......|.|::.::...:...:.:|:..:...|..::|..::.:.
Mouse  1022 ERILQYTKE---RTEEHRDLCKALGLIKDMIAAVDLKVSEYEKNQKWLEILNKIENKTYTKL--- 1080

  Fly  1793 APVGVPRAG---AKPRFLVKRGELTH---LLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRR 1851
                  :.|   .|...|.:...|.|   :.|:....:..        .|.|.|.:|:||..:.:
Mouse  1081 ------KNGHVFRKQALLSQERALLHDGLVYWKTATGRFK--------DILALLLTDVLLFLQEK 1131

  Fly  1852 GES-CFSVFDYCP-----------------RSMLTLAAGDSLPQLPTKDLKDQAGKNLILMTLLE 1898
            .:. .|:..|..|                 |.|..::|..:.|::.......:..:|
Mouse  1132 DQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERN-------- 1188

  Fly  1899 NCDRKTVELVLSCP-------SVSDQQRWLQAMRPPEAETPGEKLYESWDCPQVVAKHSYE---- 1952
            |..|:..:.|.|||       |.||::|     |..||     ::.:...|.::::....:
Mouse  1189 NWMRRIQQAVESCPEEEGGRTSESDEER-----RKAEA-----RVAKIQQCQEILSNQDQQICTY 1243

  Fly  1953 SDEPDVLQLELGDV 1966
            .:|...:..|||::
Mouse  1244 LEEKLHIYAELGEL 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	43/213 (20%)
		PH_ephexin	1805..1931	CDD:269929	31/153 (20%)
		SH3_ephexin1_like	1944..1998	CDD:212727	4/27 (15%)
Arhgef28	XP_006517581.1	C1	666..711	CDD:237996	11/71 (15%)
		RhoGEF	861..1053	CDD:238091	44/217 (20%)
		PH_p190RhoGEF	1098..1198	CDD:275430	19/115 (17%)
		xseA	<1364..1520	CDD:234714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900