DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Exn and akap13

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_021327529.1	Gene:	akap13 / 108190639	-ID:	-	Length:	1416	Species:	Danio rerio

Alignment Length:	1452	Identity:	275/1452 - (18%)
Similarity:	461/1452 - (31%)	Gaps:	535/1452 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DSENNNRATCDKAGKDNPNPNQNPNSQANPNQNC------------SCESRA------------- 100
            :.|.|.|::...||:..|...:...|.. |::.|            |.|..|
Zfish   175 EEEMNQRSSVQNAGEGKPVFYRRSLSWC-PSEPCPELEEIRKLISYSLEGLAAGIEDGKRWRSGA 238

  Fly   101 -FRDFRGVQTLRLLWSRRIKSASED-----------------QCHSP-------VHCHTSSSSLG 140
             .:|.||||          :..|||                 :|.||       .|...:|||..
Zfish   239 PSKDQRGVQ----------RQDSEDRGSLMSLTEEGPESDLGECRSPGIQKSRKYHQFRNSSSSV 293

  Fly   141 TLKKLNKSVSCLVNAFNNSRDCATPEKTLAKRAASL-HNLQDSQAKHKQL-------HREKD--- 194
            || .|.||||.|   ..:.||.....:...||..|. .||.....|.|.:       ..|:|
Zfish   294 TL-PLTKSVSML---SISQRDLDAIGRIRRKRRISFTFNLSPILPKSKSVITVSSSSSDEEDIIS 354

  Fly   195 -----------------------------------NFYKYKNAEQAKMQAKLRSSADEAILNASE 224
                                               .|...||    ||..|.|....|.  |..:
Zfish   355 MTSFSTAGNMGYSITEEEPGPLRGDFEKSSTKVSRTFSYLKN----KMYKKAREKEKEK--NREK 413

  Fly   225 TR-AKRDDSGCLPGVKSYNSKALSAADKVAKVAKGEAKTQRRAEEPVGEAEVEVEVEFRAKREH- 287
            .| ||..:.      ||.|....:|.:.:......:.......::.|......:.|. ::.||:
Zfish   414 DREAKEREK------KSVNGHLFTAVNSLHPALCQQCNKTLNTKDAVHCTNCNIRVH-KSCRENI 471

  Fly   288 -----NRLEGLSLSAASAQSGGSSESLQTTTTSSST-----------PTTHSSV----------- 325
                 :|::..::..::..      .:.|..|.|||           |..||.:
Zfish   472 PICLKSRMKQFAIPESTTM------PVVTLRTKSSTLRERPWSAIFSPEEHSVIIPSRRPTSIMP 530

  Fly   326 --TSSTGRS--------------GGRRKYSFKTHAGKSYHQHHHPSRRTSNMDSSNGGISMV-AK 373
              :|:..:|              .|||      :..:|....|.|::.|::.:|.:.|..|| ::
Zfish   531 FHSSNLSKSMSINNIAMFDDMPLSGRR------YLSQSTDSLHKPNKVTASNESLDEGTEMVDSR 589

  Fly   374 LTHQFNEIIQK----------DAKLLEQVKRNNGVWISRGTHVYKIVE----------------- 411
            |...|...:::          |.|.|:|:|::   .|.|...:|::::
Zfish   590 LMGDFEADVKELEADSWSLIVDKKYLKQLKKD---IIKRQDVIYELIQTEMHHLRTLRIMCDVYS 651

  Fly   412 ---------KPTSEGKGLPNADD-----------------------------NRISTVQRNIKKF 438
                     :|.:..|..|..||                             :||..:.  :.:|
Zfish   652 KGLLMDLQLEPQAVEKMFPMLDDLLELHSFFFSALLERKKEARLDGTDGFLIHRIGDLL--VSQF 714

  Fly   439 ERLEKPSVPLKSEQLMRKHLELMR--GSSLSRGPRIKRNLKLPPGS-----VGIPE-LAIVSEEL 495
            ......|:.....:...:|.|.:.  ....:|..|.:..::....|     :.||| :.:|::.:
Zfish   715 SDSNAESMKRIYGKFCSRHNEAVNFYKDLHARDKRFQAFIRKKMSSSVVRRLSIPECILLVTQRI 779

  Fly   496 KTPTSEEQAKKPKSVQNESQPNHPEELNQSNDKPSDEL--------DLIMGEEGDEEELRQKQRK 552
                    .|.|..:|...|  |.:|    |:|..::|        |:|...   :.::.:.::|
Zfish   780 --------TKYPVLLQRILQ--HTKE----NEKDFEDLTQAFQLLKDIIASV---DSKVNEHEKK 827

  Fly   553 HKYASIYEKLRFTFAKGRKSASPSPTKAQIREEVSIDEESIKDSTSEDMVTRKE---------DF 608
            .|...||         ||                 .|.:||....|..|..|::         |.
Zfish   828 KKLKEIY---------GR-----------------TDSKSITRMKSGQMFAREDLVRGRRLLHDG 866

  Fly   609 TLDLPKEVIPRAEDLEDSSHALLVSPCF----EADAKILDALEAVDLKLKV--LNPLNDVTTADG 667
            .|.| |....|.:|:    ||||:|...    |.|.|.:.|  ::|.:..|  |..|.....|..
Zfish   867 PLQL-KNTAGRLKDV----HALLLSDVLVFLQEKDQKYVFA--SLDQRATVISLQKLIVREVAHE 924

  Fly   668 ERELLL----AANDDFEQRILPNSSFVYQAANKQYSNNQILLNQAVNVTLVNAIEGEQMIMEQKQ 728
            ||.|.|    .||        |....|:.::.::.:....::..|::....:..||.....|:.:
Zfish   925 ERGLFLITAGIAN--------PEMVEVHASSREERNTWMQIIQDAMHSIEKDDDEGIPSETEEDR 981

  Fly   729 LMKVRDLELTERDIDQPLKRAEKSPEKDD-----TLEPESLYEPITPVMDETKTEAQTSSLFKIY 788
            .:    ||...|::.:.|:|      ||:     .||...::..    |..:..:.|...||:..
Zfish   982 KL----LETKTREMREMLQR------KDEQIVSLLLEKMKIFRE----MCGSSEDPQVKMLFRAN 1032

  Fly   789 TKKSELVEDIY-QTVEEASTVEVKPNNWLEGYESIAGSQEACPLTYDGYESFAPEEVVTTPTTPS 852
            .::....|.|. ..:.|...::...|:.|.|   ..|.|.||
Zfish  1033 NEEVAKGEPIMTDALREVEMLQALVNSSLGG---AVGQQVAC----------------------- 1071

  Fly   853 ATGTLGRNTRDELPELPKPKRVLNKSPIPLRPAPPKPQAKESEEDENIYDTIKG--CYESMHCKA 915
            |.|.:|                    |:.|      |:..|         |..|  |::...||
Zfish  1072 AQGIMG--------------------PVCL------PRRAE---------TFGGFDCHQMNTCK- 1100

  Fly   916 TSSSSSGEATLTTDTISLSSNCYESISHIRRSRVATTQNQGHGSAGSCIQLSSSGSTLTISSDHK 980
                 .||.              |....:||:...:...:| |:|...:.|..:...:..|..|.
Zfish  1101 -----HGEK--------------EEAEDLRRTESDSVLKKG-GNANLLLLLKKNSEQVLTSVTHL 1145

  Fly   981 TNSLYESSLAAAGCVVYGSASV-GCRSSLGSSAGSRDSGKP-----GDKRSSIAGSSDNSDA--- 1036
            .:.|  |||.|.  |:.....: ..|.:|.....||.|.:|     .:|:.|:.....::.|
Zfish  1146 HDLL--SSLQAV--VLQQDTFIEDQRQALSERTPSRPSSRPPSLVEQEKQRSLERHRQDAAALLR 1206

  Fly  1037 ---------------WVDISDGEIGQATTDATANEAQFIVVRERFKPHRT------------RSP 1074
                           | |:.:.|:    ||...    .:.|||.....|:            |..
Zfish  1207 QQAAHAEEKKRKEKEW-DVKEREL----TDREV----LLHVREEEVRRRSREMEEAQVQLQGRKE 1262

  Fly  1075 DWSK---RIRD-------KRLQQKKAISCIEDDSDHYYETLSPLGN----------KRHSTQLV- 1118
            |:.|   |:||       :|.|.:|.:..:|    |..|..:.|..          |.||:..:
Zfish  1263 DYQKDLERLRDAQRKLEREREQMQKEMERVE----HLREVQARLHRTPSSTSEDSLKLHSSSSIE 1323

  Fly  1119 RQSQDGNRSGGVRS---SHRRSKNHSASAHTLGEHVVISDDYDSFET------DSDDHGDGEPDL 1174
            |::.:...|...|.   |...||..|.|..:||.....::..:...|      .|.:..|.:
Zfish  1324 REAWESELSSSPRKNSLSRMDSKQKSRSLFSLGGKSQSTEGQNQMPTRLLQLATSKEKKDKK--- 1385

  Fly  1175 RQRNYNDSGVDMRNHRLPKPPP 1196
            ::::.:.:..|..:|.||...|
Zfish  1386 KKKSKSQTPQDAASHLLPLTEP 1407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015
		PH_ephexin	1805..1931	CDD:269929
		SH3_ephexin1_like	1944..1998	CDD:212727
akap13	XP_021327529.1	C1	428..472	CDD:197519	5/44 (11%)
		RhoGEF	625..818	CDD:238091	31/211 (15%)
		PH_AKAP13	862..964	CDD:275427	29/116 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900