Protein Alignment Exn and arhgef15a

DIOPT Version :10

• Sequence 1: NP_001097630.2
• Gene: Exn / 39900
• FlyBaseID: FBgn0261547
• Length: 2029
• Species: Drosophila melanogaster
• Sequence 2: XP_017211830.1
• Gene: arhgef15a / 101882903
• ZFINID: ZDB-GENE-060526-292
• Length: 924
• Species: Danio rerio
• Alignment Length: 963
• Identity: 276/963 - (28%)
• Similarity: 433/963 - (44%)
• Gaps: 174/963 - (18%)

  Fly  1131 RSSHRRSKNHSASAHTLGEHVVISDDYDSFETDSDDHGDGEPDLRQRNYNDSGVDMR----NHRL 1191
            |...|.||:.|.....||....:     ...|.:||.....|.:.:..:.:..|.::    ||:|
Zfish    71 RKDRRYSKDISQDEKHLGVEARL-----QCPTSTDDKALDIPSVTKSEHKELEVKLKADEINHQL 130

  Fly  1192 P----KPPPPQNQVYEFVRKFKDFI-SSKKSPKGSQQK-----LYENTPASTLFYVECSKRTEDV 1246
            .    :..|..::|...|....|.. .|...|..|::|     .:...|...|.:|...:  |:.
Zfish   131 AVDAGRSAPDGSEVNNSVSGNSDICQDSTAPPTMSEEKHCHCVCHLQRPGMKLVWVPLQE--ENN 193

  Fly  1247 YENT---------DFGPERIPAPETKGPVHQEQAPVLRAKQKNGKSLRSRLRKSLVGSSFDTKQL 1302
            |.:|         :.|.:|....:.:|.:|.....|       || |.:|       ::..:|.:
Zfish   194 YLDTVNEKCNRHQNSGRQRTKLQKKEGVLHLTSNEV-------GK-LENR-------TTHHSKPI 243

  Fly  1303 SSLAP---TRSTFYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCTPLPETPKFSTVARKAKKE 1364
            ..|.|   .:|..|...|.    .|.|:...:.    :....:.:..|||.....|:..:..|:.
Zfish   244 QELPPCINCQSFLYHHSPH----KLALKRFAYA----EEPIQNHSKPPLPPRTYQSSKYQNIKQY 300

  Fly  1365 AKANRRRTTIGLRPN------DPPPPPPPMTGNKSPLDPERELDAEQTTSWYAECGVFKQATNGA 1423
            |:.......:.|.|:      .||.||.|:.  :.||.|..:...|:.:|        :.:....
Zfish   301 AQHTDANIYLDLLPSKDNILTTPPVPPRPLP--RPPLHPTSKQKTEKRSS--------QPSLACV 355

  Fly  1424 VSPRGDEP----VTPTPSGHGGVSSWYAESGLYQTSGISVASSSGSSGV---STGNEAGLGDELS 1481
            :|.||..|    ::|..|..           |..::..|..::.|...:   ...:..|....:|
Zfish   356 ISLRGGYPPIRNISPCKSRR-----------LPDSTAESYENAEGWESIDKEKLSDNTGSPRRIS 409

  Fly  1482 S--EPHSLFSNEPLYQMYSA------AKLESITRD-----------LEAHGSSDGYEEIGLQAKA 1527
            |  ||:|.:  |||||:|.|      :::::::.|           ||.|||   ...:|.|:|.
Zfish   410 SDWEPNSDY--EPLYQIYQAKLSKEDSQIQTVSPDCNRRSVSETLGLEGHGS---LGVVGTQSKR 469

  Fly  1528 KPEPLVKPRPTALQLVEPKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLK 1592
            .||.:                   |||.::|.|..|.:|..||..|:..||:.||::|||||||:
Zfish   470 GPEEI-------------------TLWQDLPVVKESGMLHKLTRTEKQRQESMFEVLTSEASYLR 515

  Fly  1593 SLNLLRRHFMNHNAFLDSSVLSAKDRKALFSYIVPVHECSERLLTELEACWQDNIMLLGLSRCIY 1657
            ||.:|:.||:......::.|:  .|||.|||.::.|:|.|||.:.:|.....:::::..:|..||
Zfish   516 SLRVLKDHFLGSRELNETLVI--HDRKVLFSNLLQVYEVSERFIRDLLKRVDESVVISDVSDIIY 578

  Fly  1658 EIAERHFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRI 1722
            |.:|.||.||:.:..:|...::|..:|.||....|..  :.|||.||.|..|...||::||.|||
Zfish   579 EHSENHFSVYIDYVRNQQYQEKTYSKLMESNTDFAVV--MRRLELSPLCKRLPFTSFMLLPFQRI 641

  Fly  1723 TRLPLLIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHV 1787
            ||:.:||.:: .|.:....:|.|:....|..|.|::.|.|:...:.:|..||...:.:||| ..|
Zfish   642 TRIKILIQSI-QKRTAKGTKEEETASKALTSVSKLITQANQQVGQMKQMEELINTSNKLEF-DKV 704

  Fly  1788 RALAIAPVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCKRRG 1852
            :.:.|.        :|.|.|.|.|||..|..||.    .|..|.....:|.|||:|||:|..|:
Zfish   705 KVIPIV--------SKTRCLEKHGELQELSKRGS----LFSMRNRCSPVYMFLFNDLLILTTRK- 756

  Fly  1853 ESC---FSVFDYCPRSMLTL-AAGDSL-PQLPTKDLKDQAGKNLILMTLLENCDRKTVELVLSCP 1912
            ..|   |:|.||..||::.: |..:|| |.|          .:...:|||||....|.|.:|...
Zfish   757 SGCPDRFTVIDYAHRSLVQVQATVNSLGPHL----------DHCFSLTLLENHRGSTCEHLLKAN 811

  Fly  1913 SVSDQQRWLQAMRPPEAETPG-EKLYESWDCPQVVAKHSYESDEPDVLQLELGDVVNVSRKLPDG 1976
            :.||..||:.|. |...||.| ||:||.||||||.....|.:.:.|.|.||:.:|:||.||..:|
Zfish   812 TESDMHRWIAAF-PSINETFGEEKIYEDWDCPQVQCVDRYVAQQADELSLEVSEVINVLRKTNEG 875

  Fly  1977 WYQGERIRDGAVGWFPGSYTEELNSAHVRARNLKQRHRLLTFTATYLESQKSK 2029
            ||:|.|:.||..||||...|.|:.:.|.|.||:::::::...|     ||.|:
Zfish   876 WYEGIRLFDGKKGWFPAENTLEITTDHQRRRNVREKYQIAQST-----SQNSQ 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1762	CDD:459876	67/180 (37%)
		PH_ephexin	1805..1931	CDD:269929	46/130 (35%)
		SH3_ephexin1_like	1944..1998	CDD:212727	24/53 (45%)
arhgef15a	XP_017211830.1	RhoGEF	503..680	CDD:459876	67/181 (37%)
		PH_ephexin	703..824	CDD:269929	48/144 (33%)
		SH3_ephexin1_like	843..897	CDD:212727	24/53 (45%)