DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Exn and plekhg7

DIOPT Version :9

Sequence 1:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster
Sequence 2:	XP_004912972.1	Gene:	plekhg7 / 100492548	XenbaseID:	XB-GENE-6044182	Length:	759	Species:	Xenopus tropicalis

Alignment Length:	827	Identity:	164/827 - (19%)
Similarity:	277/827 - (33%)	Gaps:	249/827 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1199 NQVYEFVRKFKDFISSKKSPKGSQQKLYENTPASTLFYVECSKRTEDVYENTDFGPERIPAPETK 1263
            |.|.:.|:..||  ::|.:.:...:|::...|...:|    .....|...||.|..:|      :
Frog    47 NSVTKDVQICKD--NTKPTSETVHRKVHNIPPLILMF----PPNETDGNHNTPFQFDR------Q 99

  Fly  1264 GPVHQEQAPVLRAKQKN-----------------GKSLRSRLRKSLVGSSFDTKQLSSLAPTRST 1311
            .|.....:|.||..:|:                 ..|.......:|.|..:|:...|......::
Frog   100 APARISTSPTLRRLRKHTHGHFMPLQDIFDVTKFPTSKEQSALNNLAGHLWDSPPWSPQCTISTS 164

  Fly  1312 FYVEDPEGSLPALPLEPEIHGSGELDSGFSDKNCT-PLPETPKFSTVARKAKKEAKANRRRTTIG 1375
            ..|...|....|:|.:||        ...::.||| .:....::|||    .|..:.:..|..||
Frog   165 EGVSVSENDRAAIPKDPE--------ENINNNNCTDDILLHSQWSTV----DKSMEHSENRYIIG 217

  Fly  1376 LRP----NDPPPPPPPMTGNKSP----LDPERELDAEQTTSWYAECGVFKQATNGAVSPRGDEPV 1432
            ...    ||..      :||.||    |...|.|...:::...:..|:       .|.| ||..|
Frog   218 STTENYNNDDD------SGNLSPKIKALHHSRLLARRRSSVVLSLPGL-------EVFP-GDLLV 268

  Fly  1433 TPTPSGHGGVSSWYAESGLYQTSGISVASS-------SGSSGVSTGNEAGLGDELSSEPHSLFSN 1490
            :      .|.|.:     :|.::.:|.|.|       |....:..|.:..:.|
Frog   269 S------DGASDY-----MYHSTWVSSADSKKPKWPFSKKGTLMKGKQKQISD------------ 310

  Fly  1491 EPLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVEPKNGPSRTLWS 1555
              |....|:.|::..|          |.|                    |.:::.|.      |:
Frog   311 --LENCLSSVKIQDFT----------GNE--------------------LYILKDKT------WN 337

  Fly  1556 EIPEVIHSCILPTLTSRERSLQEAKFEIITSEASY-LKSLNLLRR-------HFMNHNAFLDSSV 1612
            |:..:..:.....|....|..||:.:|:.|||.:| |..|.:|::       |..:::..||..|
Frog   338 EVISMHTAENTENLHKSNRRRQESVWELFTSECTYHLDQLLVLKKVFFSALQHLQSNDHLLDVDV 402

  Fly  1613 LSAKDRKALFSYIVPVHECSERLLTELEACWQDNI-MLLGLSRCIYE---------------IAE 1661
            :                    ||...||...|::: ..:||...|..               :..
Frog   403 V--------------------RLFANLEELIQESLNFAVGLLNTIKSRELGSTASFSPPLAGLLT 447

  Fly  1662 RHFH-----VYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQR 1721
            :||.     .:..:|.:.......|..||:..:   |..:|:..|....|..|:|...|:.|:.|
Frog   448 KHFKDSLCLSHEVYCLNYTSAVIYLESLKQRDD---FAIYLKWCEQHEQCRRLHLSDLLVAPLHR 509

  Fly  1722 ITRLPLLIDAVFSKESPLNREEYESWKLTLALVQKV----VGQCNEAANRWEQAFELERIARQLE 1782
            :||.|||:..:              ||.:..:.:|:    |....|:..|     :||...:.|:
Frog   510 LTRYPLLLKNI--------------WKQSTDVTEKIAIYSVKDKVESTLR-----DLEGKVKWLD 555

  Fly  1783 FPSHVRALAIAPVGVPRAGAKPRFLVKRGELTH----------------LLWRGEDAKLTFGKRL 1831
            .....:.|....|.........||.:..|...|                ||..|   ||...:..
Frog   556 KSQKYKQLQEVIVWPSLWERDKRFFIPEGLKHHFKEPNVESMLSSLNRDLLHEG---KLILTEST 617

  Fly  1832 TKISIYAFLFSDLLLLCK----RRGESCFSVFDY-C--PRSMLTLAAGD---------SLPQLPT 1880
            ..:.:|.|||.|.||:.|    :|..:...|..| |  |...:....|.         :|.:|..
Frog   618 RLLDVYLFLFDDFLLITKIKRNKRKSTNLEVNQYPCLHPELQMVTKEGGYCKVVDQPIALDRLSL 682

  Fly  1881 KDLKDQ-----AGKNLILMTLLENCDRKTV-ELVLSCPSVSDQQRWL 1921
            |.: ||     .|.....|...||..::.: ..:|...:.|:::.|:
Frog   683 KTV-DQYHVTVYGMKNAFMVQHENRYQQCIAAFILQAHTESEKKTWM 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	44/214 (21%)
		PH_ephexin	1805..1931	CDD:269929	35/155 (23%)
		SH3_ephexin1_like	1944..1998	CDD:212727
plekhg7	XP_004912972.1	DUF4675	89..>186	CDD:374050	20/110 (18%)
		RhoGEF	362..526	CDD:214619	42/200 (21%)
		PH_PLEKHG7	604..732	CDD:270065	31/129 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910