Protein Alignment LIPC and CG6296

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_651520.1
• Gene: CG6296 / 43246
• FlyBaseID: FBgn0039470
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 289
• Identity: 90/289 - (31%)
• Similarity: 127/289 - (43%)
• Gaps: 66/289 - (22%)

Human    52 FLLFGETN--QGCQIRINHPDTLQECGFNSSLPLVMIIHGWS---VDG----VLENWI----WQM 103
            |.|:...|  .|.||:... |::....||...|..:.||||:   .||    |.:.|.    :.|
  Fly    73 FYLYTLQNPSTGQQIKATQ-DSIDGSFFNPQNPTRITIHGWNSNYKDGVNTRVADAWFQYGDYNM 136

Human   104 VAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYS 168
            :|              |||:......|..:|......||:||||:.:|.|...:|...:.::|:|
  Fly   137 IA--------------VDWLRGRSLEYASSVAGAPGAGKKVAALVDFLVEGYGMSLDTLEIVGFS 187

Human   169 LGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVG 233
            |||||:|.....: .:.|:|::.|||.|.||...|....|||.|||.:|::|.|     .|..:|
  Fly   188 LGAHVAGHTAKQV-NSGKVGKVVGLDPASPLISYSNTEKRLSSDDALYVESIQT-----NGAILG 246

Human   234 IKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSM 298
            ..||||...||.|||..||||               .|..|..|||.::|..::::||
  Fly   247 FGQPIGKASFYMNGGRSQPGC---------------GIDITGSCSHTKAVLYYVEALL------- 289

Human   299 AYPCGDMNSFSQGLC---LSCKKGRC-NT 323
                  .|:|....|   :...|..| ||
  Fly   290 ------WNNFPSIKCESSVDANKNNCGNT 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	90/289 (31%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		3/22 (14%)
		PLAT_LPL	352..487	CDD:238856
CG6296	NP_651520.1	Pancreat_lipase_like	71..337	CDD:238363	90/289 (31%)
		MSCRAMM_ClfA	<334..621	CDD:468110