Protein Alignment LIPC and CG4582

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_651403.1
• Gene: CG4582 / 43086
• FlyBaseID: FBgn0039344
• Length: 432
• Species: Drosophila melanogaster
• Alignment Length: 344
• Identity: 96/344 - (27%)
• Similarity: 146/344 - (42%)
• Gaps: 52/344 - (15%)

Human    25 QSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQ-----IRINHPDTLQECGFNSSLPLV 84
            :|.|..|..|..|.|..|..........:..|:..|..|     :.:....:|:...|:...|..
  Fly   102 KSEKESPHRRLFQQVVGNTLTAAFGLNVMNKGDQEQNQQFTSEPVNLYDAASLRRSRFSPFNPTR 166

Human    85 MIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLR 149
            ::|||| :.....|...:::.|.........|:..|||...|...|..|....:.||:.:|..:.
  Fly   167 ILIHGW-LGNENANMYNELLPAYFDLRNGNYNIFTVDWGRGAIADYITASYRVKPVGQVLAKFVD 230

Human   150 WLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDA 214
            :|.:...:....:.|:|:|:||||:|.||..: .|.::..|..||.|.|.|..:.|..||:.:||
  Fly   231 FLHQEAGMRFEDLQLVGFSMGAHVAGLAGKHL-QTGRLRMIRALDPALPFFRYAKPKERLTAEDA 294

Human   215 NFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSH 279
            ::|:.:||    .:| |.|..:|:||.|||.|.||.||||.:.|                  |||
  Fly   295 DYVEVLHT----SVG-SYGFDRPVGHVDFYANWGSQQPGCFWHE------------------CSH 336

Human   280 ERSVHLFIDSLLH---AGTQSMAYPCGDMNSFSQGLCLSCKK--GRCNTLG---YHVRQEPRSKS 336
            .|:..||.:||..   .|..|...|..:....::  ...|.|  |...|:|   .:|..|
  Fly   337 WRAFMLFAESLARDQATGFLSQGCPAAEWQQLTR--FHRCPKDTGVMQTMGGDLANVSAE----- 394

Human   337 KRLFLVTRAQSPFKVYHYQ 355
               ||..|.    .||::|
  Fly   395 ---FLAQRQ----GVYYFQ 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	93/336 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		2/22 (9%)
		PLAT_LPL	352..487	CDD:238856	2/4 (50%)
CG4582	NP_651403.1	Pancreat_lipase_like	138..409	CDD:238363	87/308 (28%)