Protein Alignment LIPC and CG5665

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_001246844.1
• Gene: CG5665 / 40243
• FlyBaseID: FBgn0036977
• Length: 395
• Species: Drosophila melanogaster
• Alignment Length: 289
• Identity: 85/289 - (29%)
• Similarity: 118/289 - (40%)
• Gaps: 71/289 - (24%)

Human    77 FNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQ-PVNVGLVDWITLAHDHYTIAVRNTRLV 140
            |:....:|::..||: :.|.|:....|::  |:...: .||..:||........|..:..||.|:
  Fly   113 FSKGRKVVILATGWT-NTVNESSAISMIS--KAFMCRGDVNFVIVDAADYVDTFYAWSALNTDLI 174

Human   141 GKEVAALLRWLEESVQLSRSHV-----------------HLIGYSLGAHVSGFAGSSIGG-THK- 186
            |:.:...|..|.|...|...|:                 ..:|:|||||:.|.||.:... |.|
  Fly   175 GEHIGVGLTHLIELTPLRNIHLIGGFIKESFVSINSGSDFFVGHSLGAHIMGTAGRTFKKLTGKL 239

Human   187 IGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGI---KQPIGHYDFYPNGG 248
            |.||||||.|.|.|........|:..||..||.|||        ::||   :.|:|..||||.|.
  Fly   240 IPRITGLDPAKPCFRREKILPGLTRGDAKLVDIIHT--------NIGILAKRGPLGDVDFYPGGA 296

Human   249 -SFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGL 312
             ..||||                  .||.|||.|:|..|.:|         |||..:.| |....
  Fly   297 HPIQPGC------------------LTIGCSHTRAVEYFAES---------AYPHQEKN-FMGKK 333

Human   313 CLS--------CKKGRCNTLGYHVRQEPR 333
            |.|        |..|..:.:||.:..:.|
  Fly   334 CASWDELRKRDCSAGIVSPMGYRMNPQAR 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	85/289 (29%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		3/22 (14%)
		PLAT_LPL	352..487	CDD:238856
CG5665	NP_001246844.1	alpha/beta hydrolases	85..370	CDD:473884	85/289 (29%)