Protein Alignment LIPC and CG10116

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_648652.1
• Gene: CG10116 / 39515
• FlyBaseID: FBgn0036367
• Length: 289
• Species: Drosophila melanogaster
• Alignment Length: 295
• Identity: 78/295 - (26%)
• Similarity: 128/295 - (43%)
• Gaps: 57/295 - (19%)

Human    70 DTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAA-LKSQPAQPVNVGLVDWITLAHDHYTIA 133
            :.|....|.::.|.|:.|..| :..:....|..:|:| |:.|.:..::|.|.:    |:|
  Fly    43 EALVRSSFYAADPTVVTIPRW-LGNISSPEIPAVVSARLQQQDSNIISVDLSE----AND----- 97

Human   134 VRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGR----ITGLD 194
              .|.:: ..||:|:..|.....:....:.::|::.|||::|...:.:  ...:||    ||.||
  Fly    98 --ETEII-DSVASLVIVLHNQFDMPLDRILVVGFAEGAHLAGGVAAKV--QQDLGRQLSQITALD 157

Human   195 AAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLEL 259
            .:    .|:...::||..||.||:.:||    :.| ..|..:.:||.|:|||||..||||
  Fly   158 PS----SGAELDHKLSQADAEFVEVVHT----NAG-GEGTWERLGHVDYYPNGGQTQPGC----- 208

Human   260 YRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTL 324
                         .|..|||||:..|..: :.......::..||.:.:.|...|      |.:|.
  Fly   209 -------------TTDSCSHERAFELLAE-MWSPENDFVSARCGSVETLSASSC------RWSTH 253

Human   325 GYHVRQEPRSKSKRL-FLVTRAQSPFK--VYHYQF 356
            ....:||....:..: ||.||..|||.  .|...|
  Fly   254 KMGQKQEEEQPASGIYFLETRQSSPFSRGAYFISF 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	74/284 (26%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		2/22 (9%)
		PLAT_LPL	352..487	CDD:238856	2/5 (40%)
CG10116	NP_648652.1	alpha/beta hydrolases	24..274	CDD:473884	71/279 (25%)