Protein Alignment LIPC and CG6675

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_610132.3
• Gene: CG6675 / 35439
• FlyBaseID: FBgn0032973
• Length: 390
• Species: Drosophila melanogaster
• Alignment Length: 339
• Identity: 95/339 - (28%)
• Similarity: 144/339 - (42%)
• Gaps: 83/339 - (24%)

Human    31 PFGRRAQAVETNKTLHEMKTRFLLFGETNQGC--QIRINHPDTLQECGFNSSLPLVMIIHGW--- 90
            |||.:           :::..|.||......|  ::..:.....:.||||:|||..::||||
  Fly   110 PFGSK-----------KLRMHFYLFKREFPECGREVDFSIERKWRHCGFNASLPTRLMIHGWMSQ 163

Human    91 ---SVDGVLENWIWQMVAALKSQPAQPVNVGLVDW-ITLAHDHYTIAVRNTRLVGKEVAALLRWL 151
               |.:..::|      |.||.   ...||.:||| .:.|:.:|...|:.....|.|:|..:|.|
  Fly   164 SRGSFNRDVKN------AYLKK---GEYNVIVVDWSASSANINYFSVVKLIETFGAELAQFIRNL 219

Human   152 EESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANF 216
            ..........::|||:||||.::|.||..:... |:..|..||.|||.|.......|:.|.||.:
  Fly   220 NRQFGADFDSMYLIGHSLGAQIAGSAGKRLKPV-KVNTIFALDPAGPKFRHRGTEFRIDPSDAKY 283

Human   217 VDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHER 281
            |:::||      ..:.|.::|.|...||||.|::|..|::|                  .|||.|
  Fly   284 VESMHT------SANFGFRRPTGSATFYPNYGAYQHSCYYL------------------GCSHIR 324

Human   282 SVHLFIDSLLHA----GTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQ------EPRSKS 336
            |..:|.:|:...    ||     ||...|.          :.:|:   |..||      ||....
  Fly   325 SYQMFAESINSPLGFWGT-----PCIRDNG----------RWQCD---YSQRQSIQMAGEPSIHK 371

Human   337 KRLFLV-TRAQSPF 349
            :.:|.| |.:..||
  Fly   372 EGIFYVKTSSSDPF 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	93/337 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		2/22 (9%)
		PLAT_LPL	352..487	CDD:238856
CG6675	NP_610132.3	Pancreat_lipase_like	116..381	CDD:238363	90/316 (28%)