Protein Alignment LIPC and CG6431

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_001188790.1
• Gene: CG6431 / 34476
• FlyBaseID: FBgn0032289
• Length: 351
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 87/283 - (30%)
• Similarity: 132/283 - (46%)
• Gaps: 45/283 - (15%)

Human    60 QGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWIT 124
            :|..:.:.:|.||.:.||:.....|.||||::...:..:..:...|.|    ::..||..|||..
  Fly    73 RGTPLNVKNPITLYKGGFSKHRETVFIIHGFNGTAIDIHLQFLRDAYL----SRDFNVITVDWRP 133

Human   125 LA-HDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIG 188
            |. :..|..::.||||..:..|.:..:|.....: |..:..:|:|||||:.|...:.:  |.|..
  Fly   134 LTRYPCYLHSLINTRLTAQCTAQIYAFLTHYGAV-RERITCVGHSLGAHICGMISNHL--TRKQY 195

Human   189 RITGLDAAGPLFEGSAPSN--RLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQ 251
            ||.|||.|.||.| ...||  |||.||||.:..:||    :.|. :|.:...||.::..|||..|
  Fly   196 RIIGLDPARPLIE-RMKSNKFRLSIDDANVIQVLHT----NAGF-LGQEDNSGHLNYCVNGGRIQ 254

Human   252 PGCHFLELYRHIAQHGFNAITQTIKCSHERSV-HLFIDSLLHAGTQSMAYPC--GDMN-SFSQGL 312
            |.|.            .|.|.:: :|||..|: :|...:..|  .:.|..||  |.:| |.|:.|
  Fly   255 PFCK------------GNPIRKS-RCSHFLSICYLATATFKH--NKFMGVPCPNGCLNLSGSKRL 304

Human   313 CLSCKKGRCNTL-------GYHV 328
            .:|   |:.|..       .||:
  Fly   305 PVS---GKVNPFEFASLIREYHI 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	87/283 (31%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		3/22 (14%)
		PLAT_LPL	352..487	CDD:238856
CG6431	NP_001188790.1	alpha/beta hydrolases	63..293	CDD:473884	77/247 (31%)