Protein Alignment LIPC and CG14034

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_001036339.1
• Gene: CG14034 / 33751
• FlyBaseID: FBgn0250847
• Length: 338
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 94/311 - (30%)
• Similarity: 142/311 - (45%)
• Gaps: 55/311 - (17%)

Human    52 FLLFGETNQ-GCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQP---A 112
            |.|:.:.|| |.::.:..   |....|....||.::|||:       |.........:.:|   .
  Fly    40 FWLYTKENQEGTKLSVFE---LNRFEFYHHKPLKVLIHGF-------NGHRDFSPNTQLRPLFLT 94

Human   113 QPVNVGLVDWITLAHDH-YTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGF 176
            |..|:..:|:..||::. ||.||.|.:.|.:..|.|||.|.||..:....:||||..|||||:||
  Fly    95 QDYNLISLDYPKLAYEPCYTEAVHNAKYVARCTAQLLRVLLESGLVKIEDLHLIGLGLGAHVAGF 159

Human   177 AGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHY 241
            .|..: ..||:..||.||.|.|.:....|:.:|.|.||.|||.:||..     ..:|:...:||.
  Fly   160 IGQFL-PEHKLEHITALDPAKPFYMVKDPALKLDPTDAKFVDVVHTDV-----TMLGLLDAVGHV 218

Human   242 DFYPNGGSFQPGC--------HFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSM 298
            |||.|.|..||.|        ||                    |.|.|:...:.:| :.:.:...
  Fly   219 DFYLNMGVSQPNCGPINKMETHF--------------------CYHNRAADYYAES-ISSPSGFY 262

Human   299 AYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPF 349
            .:.|.:..||::|:|:..|  ....:|:||  :|:::. |.||.|....|:
  Fly   263 GFYCPNFKSFAKGICIPDK--NIELMGFHV--DPKARG-RYFLDTNNGPPY 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	93/309 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		3/30 (10%)
		PLAT_LPL	352..487	CDD:238856
CG14034	NP_001036339.1	Pancreat_lipase_like	37..303	CDD:238363	92/304 (30%)