Protein Alignment LIPC and CG4267

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_608661.1
• Gene: CG4267 / 33405
• FlyBaseID: FBgn0264979
• Length: 374
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 89/336 - (26%)
• Similarity: 144/336 - (42%)
• Gaps: 61/336 - (18%)

Human    49 KTRFLLFGETNQGC--QIRINHPDTLQECGFNSSLPLVMIIHGW-------SVDGVLENWIWQMV 104
            |.:|:||......|  ::.:...:.|:..||::.....::||||       .:..|...::....
  Fly    71 KMQFILFKRDFADCGRELFVGDVENLRNSGFDARHQTRIVIHGWMSQSKGSHIRKVKNAYLSLTD 135

Human   105 AALKSQPA--QPVNVGLVDWI-TLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIG 166
            .....:||  :..||.:.||. |..:.:|....:....:|..:|.|:|:|.:...:....|::||
  Fly   136 PGPNGEPAPYEDFNVIVCDWSKTSTNVNYYEVAKTVEDMGALLAELVRYLNQEANMHYDDVYVIG 200

Human   167 YSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLS 231
            :||||.::|.||..| ..::...|..||.|||.|...:...|:...||::|::|.|      .:|
  Fly   201 HSLGAQIAGSAGKQI-MPYRFNTIYALDPAGPQFREKSDEYRIDASDASYVESIQT------SVS 258

Human   232 VGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQ 296
            .|.:||:||..||||.|..|..|:.         :|         |||:||...||:||
  Fly   259 FGFEQPVGHATFYPNYGKNQKKCYV---------YG---------CSHKRSHDYFIESL------ 299

Human   297 SMAYPCGDMNSFSQGLCLSCKKGRCNTL----GYHVRQEPR-SKSKRLFLVTRAQSPFKVYHYQF 356
              ..|.|    |....|.....|....|    .:.:..||. .|:...::.|.::.|:.:.|..
  Fly   300 --TSPAG----FWGPRCERHDDGTWLLLMSDGEFRMGGEPSIPKNGTFYVKTYSKPPYAMGHRW- 357

Human   357 KIQFINQTETP 367
                  |||.|
  Fly   358 ------QTEPP 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	83/316 (26%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		2/22 (9%)
		PLAT_LPL	352..487	CDD:238856	5/16 (31%)
CG4267	NP_608661.1	Pancreat_lipase_like	71..347	CDD:238363	83/312 (27%)