Protein Alignment LIPC and CG18258

DIOPT Version :10

• Sequence 1: NP_000227.2
• Gene: LIPC / 3990
• HGNCID: 6619
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_573201.1
• Gene: CG18258 / 32708
• FlyBaseID: FBgn0265267
• Length: 468
• Species: Drosophila melanogaster
• Alignment Length: 386
• Identity: 104/386 - (26%)
• Similarity: 159/386 - (41%)
• Gaps: 92/386 - (23%)

Human     6 LCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEM-KTRFLLFGETNQGCQ---IRI 66
            |.||.|..:|..|..  ||              |..:|.:.:| :..|||  .::..||   |.:
  Fly   143 LGFSTLNYICSTIVD--LG--------------VVRSKLIPDMSRMSFLL--RSSDDCQNTSIPL 189

Human    67 NHPDTL-QECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPV----------NVGLV 120
            ...:.| ...||....|.|:.|.||:             .::.:..:.||          ||.::
  Fly   190 TQAEQLWNTTGFYQDRPTVLFITGWT-------------TSINNSNSGPVAKAYLCRNDTNVLIL 241

Human   121 DWITLAHDHYTIAVRNTRLVGKEVA-ALLRWLEESVQLSRSHV----HLIGYSLGAHVSGFAGSS 180
            |........||.:..||.::|..:| ||||       |:.|:|    ||:|:||||.::|.||.:
  Fly   242 DAANFIDTLYTWSALNTEVIGDYLAKALLR-------LNTSYVTKQFHLVGHSLGAQIAGSAGRN 299

Human   181 ---IGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYD 242
               :.|...:.||||||.|.|.|........|...||.|||.|||    :.|: .|..:..|..|
  Fly   300 YRRLSGGQILKRITGLDPANPCFYDGNELEGLRSGDARFVDIIHT----NPGM-FGTSKRAGDAD 359

Human   243 FYPNGG-SFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHA-GTQSMAYPCGDM 305
            |:..|. .|:|||..|:               .|.|||:|:|..:.:::..: |...:|..|
  Fly   360 FFVQGRIPFKPGCESLD---------------PISCSHQRAVDYWTETVYPSNGNDFLAKRC--- 406

Human   306 NSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTET 366
            ..:|:.|..:..|.....:||      .:|:..|.|.....:|.:.|.....:|....::|
  Fly   407 KRYSELLLGNYCKNTNTVMGY------AAKATDLGLFYVGANPEEPYGQNANLQSYTNSDT 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIPC	NP_000227.2	Lipase	24..349	CDD:395099	93/349 (27%)
		Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706	254..277		3/22 (14%)
		PLAT_LPL	352..487	CDD:238856	3/15 (20%)
CG18258	NP_573201.1	Pancreat_lipase_like	172..443	CDD:238363	89/321 (28%)