Protein Alignment RHOH and Mtl

DIOPT Version :10

• Sequence 1: NP_004301.1
• Gene: RHOH / 399
• HGNCID: 686
• Length: 191
• Species: Homo sapiens
• Sequence 2: NP_524533.1
• Gene: Mtl / 43319
• FlyBaseID: FBgn0039532
• Length: 195
• Species: Drosophila melanogaster
• Alignment Length: 187
• Identity: 84/187 - (44%)
• Similarity: 122/187 - (65%)
• Gaps: 9/187 - (4%)

Human     5 IKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIR 69
            ||||:|||..||||.:|:.:|::.||..|.|||::|....:.:|.||:|||||||||.:.:..:|
  Fly     7 IKCVVVGDGTVGKTCMLISYTTDCFPGEYVPTVFDNYSAPMQVDTIQVSLGLWDTAGQEDYDRLR 71

Human    70 PLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQRE-------MGPHR 127
            ||||.|.||.|:|||||:.:||.|:.:||..||:.:.|..|:::|.|:.|.||       :....
  Fly    72 PLSYPQTDVFLICYSVASPSSFENVTSKWYPEIKHHCPDAPIILVGTKIDLREDRETLSGLAEQG 136

Human   128 ASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAV--NQARRRNRRRL 182
            .:.:...:|:|||..:||..|:|||||:.||::.|||.|||..:  ...:||.|:.|
  Fly   137 LTPLKREQGQKLANKIRAVKYMECSALTQRGLKPVFEEAVRAVLRPEPLKRRQRKCL 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOH	NP_004301.1	Rho	5..169	CDD:206641	79/170 (46%)
		Effector region. /evidence=ECO:0000250	33..41		4/7 (57%)
		Interaction with ZAP70. /evidence=ECO:0000250	73..86		8/12 (67%)
Mtl	NP_524533.1	RHO	9..182	CDD:197554	78/172 (45%)