DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RHOH and Rac1

DIOPT Version :9

Sequence 1:	NP_001265288.1	Gene:	RHOH / 399	HGNCID:	686	Length:	191	Species:	Homo sapiens
Sequence 2:	NP_001261247.1	Gene:	Rac1 / 38146	FlyBaseID:	FBgn0010333	Length:	192	Species:	Drosophila melanogaster

Alignment Length:	177	Identity:	74/177 - (41%)
Similarity:	117/177 - (66%)	Gaps:	7/177 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     2 LSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFR 66
            :.:||||:|||.|||||.||:.:|:..||..|.|||::|...:|.:|...|:||||||||.:.:.
  Fly     1 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYD 65

Human    67 SIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQRE-------MG 124
            .:|||||.|.||.|:|:|:.|..||.|::.||..|:|.:.|.||:::|.|:.|.|:       :.
  Fly    66 RLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGTKLDLRDDKNTIEKLR 130

Human   125 PHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAV 171
            ..:.:.:...:|..:|:::.|..|||||||:.:|::.||:.|:|:.:
  Fly   131 DKKLAPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRSVL 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RHOH	NP_001265288.1	Rho	5..169	CDD:206641	73/170 (43%)
		Effector region. /evidence=ECO:0000250	33..41		4/7 (57%)
		Interaction with ZAP70. /evidence=ECO:0000250	73..86		7/12 (58%)
Rac1	NP_001261247.1	Rac1_like	3..176	CDD:206663	74/172 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091615at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920