Protein Alignment Nc73EF and ogdhl

DIOPT Version :9

• Sequence 1: NP_001097629.1
• Gene: Nc73EF / 39899
• FlyBaseID: FBgn0010352
• Length: 1105
• Species: Drosophila melanogaster
• Sequence 2: XP_687615.2
• Gene: ogdhl / 559207
• ZFINID: ZDB-GENE-111201-4
• Length: 1008
• Species: Danio rerio
• Alignment Length: 1108
• Identity: 630/1108 - (56%)
• Similarity: 765/1108 - (69%)
• Gaps: 127/1108 - (11%)

  Fly    12 LSPMAHKNFATWLLKSSSSQQMAKVTAAAAV----RTYNSAAAEPFANGSTASYVEEMYNAWLRD 72
            |.|:|      ..|:|||......|.....|    |..:|...||.....::|||.|||.|||.|
Zfish     4 LRPLA------GALRSSSQWMRGHVGTGKRVFDLRRNCSSGVTEPSLAACSSSYVVEMYYAWLED 62

  Fly    73 PTSVHTSWDAYFRSNSYVSPPNLAPVQANTLPLTAFNFGGAVAGA-APDSKTIDDHLAVQAIIRS 136
            ..:||.||||||| |:..|    :.|::...||:....|..::.. |...|.::|||||..:||:
Zfish    63 HKNVHESWDAYFR-NAEAS----SSVESGEKPLSMLLQGRTMSQTPAMSEKVVEDHLAVHTLIRA 122

  Fly   137 YQIRGHNIAHLDPLEINTPEL----PGNSSTKSI--YANFSFGEQDMDRQFKLPSTTFIGGDEAS 195
            ||:|||::|.||||.|.|.:|    |.:..| ||  .|::...|.|:|:.|:||.||||||:|.:
Zfish   123 YQVRGHHVARLDPLGILTADLDSFVPSDLIT-SIDKLASYGLEESDLDKSFQLPLTTFIGGNENT 186

  Fly   196 LPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEKRLILARLTRATGFE 260
            |||:||::|||..||...||||||||::|||.|||::|||||::.||..|||.:||||.|:|.||
Zfish   187 LPLREIIHRLETSYCGHTGVEFMFINNMEQCQWIRQKFETPGIMKFSAREKRTLLARLVRSTRFE 251

  Fly   261 AFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLNTLANVCRKPLNQIF 325
            .|||:|:||||||||||||::|||||.|||.|:|.|:||||||||||||||.||||.||.|:|||
Zfish   252 DFLARKWSSEKRFGLEGCEVLIPALKMIIDKSSEAGIESVIMGMPHRGRLNVLANVVRKDLDQIF 316

  Fly   326 TQF-AGLEAADDGSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVDPVVQGKTRAEQFYR 389
            .|| ..|||||:||||||||||.|.||:||.|:|||.|:::|||||||||||||||||:||||||
Zfish   317 CQFDPKLEAADEGSGDVKYHLGMYHERINRETDKNITLSLMANPSHLEAVDPVVQGKTKAEQFYR 381

  Fly   390 GDQEGKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPY 454
            ||.||::|||||:||||||.||||||||.|||:||.|||:||||||.|||||||||||.:|||||
Zfish   382 GDTEGRRVMSILMHGDAAFAGQGVVYETFHLSELPSYTTYGTIHVVVNNQIGFTTDPRMARSSPY 446

  Fly   455 CTDVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPL 519
            .|||||||||||||||||||||||:|||:|||||.||:||.|||||.|||.||||:|||||||||
Zfish   447 PTDVARVVNAPIFHVNADDPEAVMYVCKIAAEWRTTFNKDVVIDLVCYRRFGHNEMDEPMFTQPL 511

  Fly   520 MYQKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTETHVKYKDWLDSPWS 584
            ||::|||.::.|..||||||:||.||.:|.:...|||:.|||||:..:|.|..:..:.||||||.
Zfish   512 MYKQIRKQEHVLKKYADKLISEGVVTLQEFEEEVAKYDKICEEAYTSSKDEKILHIRHWLDSPWP 576

  Fly   585 GFF--EGKDPLKVAP-TGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAARKAMVDEKVADW 646
            .||  :|:......| ||:.||.|.|||...||.|  ..:|.||.||.|:|..|..|:.:::|||
Zfish   577 DFFKPDGEPKSMSCPSTGLSEEVLKHIGEVASSVP--LKDFAIHSGLSRILRGRADMITKRMADW 639

  Fly   647 ALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPYSVSNS 711
            ||.|.||||||||:||||||||||||||||||||||||.|.|||.....:.|::.:||.|:|.||
Zfish   640 ALAEYMAFGSLLKDGIHVRLSGQDVERGTFSHRHHVLHDQEVDKRFCVPMNHLWQNQALYTVCNS 704

  Fly   712 SLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQSGLVMLLPHGM 776
            |||||.|||||.|::|.||||||.||||||||.||||.|||||||:||:||||.:|:|:||||||
Zfish   705 SLSEYGVLGFELGFAMANPNALVCWEAQFGDFHNTAQCIIDQFISAGQAKWVRHNGIVLLLPHGM 769

  Fly   777 EGMGPEHSSCRVERFLQMSSDDPDYFPPESDEFGVRQLHDINWIVANCSTPANYYHILRRQIALP 841
            |||||||||.|.|||||||.||||.:|..:.:|.|:||:|.||||.||||||:|:|:|||||.||
Zfish   770 EGMGPEHSSARPERFLQMSKDDPDRYPEYTGDFEVQQLYDCNWIVVNCSTPASYFHVLRRQILLP 834

  Fly   842 FRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGPAGQNPSNVKKVVFCSGRVYYDLTK 906
            ||||||:.|||||||.|||:|.|.||..|::|.|:|||:|||.:||..||:|:||:|:|||:|.|
Zfish   835 FRKPLIIFTPKSLLRLPEARSSFDEMVTGTKFIRVIPDDGPASKNPEKVKRVIFCTGKVYYELAK 899

  Fly   907 TRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAELVWAQEEHKNQGSWTYVQPRFLTALNH 971
            .|::.:||..:||||:||||||||||:|.:...|.||||:|.||||||.|.:.|::|||||.
Zfish   900 ERKQLKLEENVAIVRLEQISPFPFDLIKAEVEKYSNAELIWCQEEHKNMGYYDYIRPRFLTV--- 961

  Fly   972 SRDVSQSDEQSSSTNTTTTTDHTNHESDTDSDSKSKPWLSRMFAAPNSSTGGDPKDPAQTLGGDF 1036
                                                                .||:|
Zfish   962 ----------------------------------------------------QPKNP-------- 966

  Fly  1037 NAAKHFDLKNVRHDFNRPAGIAAAPGARIAKTGRKISYVGRACGASTATGSKAQHIRELNALLND 1101
                                               |.||||...|:.|||:|..|:.||...|:.
Zfish   967 -----------------------------------IWYVGRDPAAAPATGNKFTHLAELKRFLDT 996

  Fly  1102 AIS 1104
            |.:
Zfish   997 AFN 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696	20/34 (59%)
		sucA	53..1104	CDD:236499	617/1061 (58%)
		TPP_E1_OGDC_like	259..521	CDD:238974	212/262 (81%)
		Transket_pyr	645..856	CDD:280874	156/210 (74%)
		OxoGdeHyase_C	863..1102	CDD:293475	79/238 (33%)
ogdhl	XP_687615.2	sucA	44..999	CDD:236499	617/1060 (58%)
		2-oxogl_dehyd_N	44..78	CDD:292696	20/34 (59%)
		TPP_E1_OGDC_like	250..513	CDD:238974	212/262 (81%)
		Transket_pyr	635..849	CDD:280874	157/213 (74%)
		OxoGdeHyase_C	856..998	CDD:293475	79/239 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574857
Domainoid	1	1.000	495	1.000	Domainoid score	I348
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1242	1.000	Inparanoid score	I174
OMA	1	1.010	-	-		QHG62893
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	1	1.000	-	-		otm25907
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	LDO	PTHR23152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R861
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800