DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nc73EF and OGDHL

DIOPT Version :9

Sequence 1:NP_001097629.1 Gene:Nc73EF / 39899 FlyBaseID:FBgn0010352 Length:1105 Species:Drosophila melanogaster
Sequence 2:NP_001334748.1 Gene:OGDHL / 55753 HGNCID:25590 Length:1010 Species:Homo sapiens


Alignment Length:977 Identity:611/977 - (62%)
Similarity:738/977 - (75%) Gaps:38/977 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 LLKSSSSQQMAKVTAAAAVRTY--NSAAAEPFA------NGSTASYVEEMYNAWLRDPTSVHTSW 80
            ||.|....|.|::.||..|..:  .|.::.|.|      .|..:||:||||.|||.:|.|||.||
Human     6 LLPSRLGVQAARLLAAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWLENPQSVHKSW 70

  Fly    81 DAYFRSNSYVS--------PPNLAPVQANTLPLTAFNFGGAVAGAAPDSKTIDDHLAVQAIIRSY 137
            |::||..|..:        ||::.....:           ||:.....||.::||||||::||:|
Human    71 DSFFREASEEAFSGSAQPRPPSVVHESRS-----------AVSSRTKTSKLVEDHLAVQSLIRAY 124

  Fly   138 QIRGHNIAHLDPLEINTPEL----PGN-SSTKSIYANFSFGEQDMDRQFKLPSTTFIGGDEASLP 197
            |||||::|.||||.|...:|    |.: .:|....|.:...|.|:|::|:||:||||||.|.:|.
Human   125 QIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFQLPTTTFIGGSENTLS 189

  Fly   198 LKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEKRLILARLTRATGFEAF 262
            |:||:.||||.||..||:||||||.:|||.|||::||||||:.||.||||.:||||.|:..||.|
Human   190 LREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMQFSSEEKRTLLARLVRSMRFEDF 254

  Fly   263 LAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLNTLANVCRKPLNQIFTQ 327
            ||:|:||||||||||||:||||||.|||.|:|:|:|:||:|||||||||.||||.||.|.|||.|
Human   255 LARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQ 319

  Fly   328 F-AGLEAADDGSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVDPVVQGKTRAEQFYRGD 391
            | ..|||||:||||||||||.|.||:|||||:||.|::||||||||||||||||||:||||||||
Human   320 FDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGD 384

  Fly   392 QEGKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPYCT 456
            .:||||||||:||||||.||||||||.||||||.|||:||:|||.|||||||||||.:|||||.|
Human   385 AQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPT 449

  Fly   457 DVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPLMY 521
            |||||||||||||||||||||::||.||||||.||:||.|:|||.|||.||||:|||||||||||
Human   450 DVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMY 514

  Fly   522 QKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTETHVKYKDWLDSPWSGF 586
            ::|.:....|..||||||||||||.:|.:...|||:.|||||:..:|.:..:..|.||||||.||
Human   515 KQIHRQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGF 579

  Fly   587 F--EGKDPLKVAP-TGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAARKAMVDEKVADWAL 648
            |  :|:......| ||:.|:.|.|||:..||.|  ..:|.||.||.|:|..|..|...:..||||
Human   580 FNVDGEPKSMTCPATGIPEDMLTHIGSVASSVP--LEDFKIHTGLSRILRGRADMTKNRTVDWAL 642

  Fly   649 GEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPYSVSNSSL 713
            .|.|||||||||||||||||||||||||||||||||.|.||:.|...:.|::||||||:|.||||
Human   643 AEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPYTVCNSSL 707

  Fly   714 SEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQSGLVMLLPHGMEG 778
            |||.|||||.||:|.:||||||||||||||.||||.|||||||:||:||||.:|:|:||||||||
Human   708 SEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEG 772

  Fly   779 MGPEHSSCRVERFLQMSSDDPDYFPPESDEFGVRQLHDINWIVANCSTPANYYHILRRQIALPFR 843
            |||||||.|.|||||||:||.|.:|..:.:|.|.||:|.||||.||||||||:|:|||||.||||
Human   773 MGPEHSSARPERFLQMSNDDSDAYPAFTKDFEVSQLYDCNWIVVNCSTPANYFHVLRRQILLPFR 837

  Fly   844 KPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGPAGQNPSNVKKVVFCSGRVYYDLTKTR 908
            ||||:.|||||||||||||.|.:|..|:.|||:||::|.|.:.|..|::::||:|:|||||.|.|
Human   838 KPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAARAPEQVQRLIFCTGKVYYDLVKER 902

  Fly   909 REKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAELVWAQEEHKNQGSWTYVQPRFLTALNHSR 973
            ..:.||.::||.|:||||||||||:|::|..|..|||.|.||||||.|.:.|:.|||:|.|..:|
Human   903 SSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFMTILRRAR 967

  Fly   974 DV 975
            .:
Human   968 PI 969

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nc73EFNP_001097629.1 2-oxogl_dehyd_N 51..86 CDD:292696 20/40 (50%)
sucA 53..1104 CDD:236499 601/946 (64%)
TPP_E1_OGDC_like 259..521 CDD:238974 212/262 (81%)
Transket_pyr 645..856 CDD:280874 161/210 (77%)
OxoGdeHyase_C 863..1102 CDD:293475 58/113 (51%)
OGDHLNP_001334748.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..100 2/29 (7%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141949
Domainoid 1 1.000 492 1.000 Domainoid score I365
eggNOG 1 0.900 - - E1_COG0567
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1225 1.000 Inparanoid score I188
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG62893
OrthoDB 1 1.010 - - D134699at2759
OrthoFinder 1 1.000 - - FOG0000624
OrthoInspector 1 1.000 - - otm41679
orthoMCL 1 0.900 - - OOG6_100311
Panther 1 1.100 - - LDO PTHR23152
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R861
SonicParanoid 1 1.000 - - X894
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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