DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nc73EF and DHTKD1

DIOPT Version :9

Sequence 1:	NP_001097629.1	Gene:	Nc73EF / 39899	FlyBaseID:	FBgn0010352	Length:	1105	Species:	Drosophila melanogaster
Sequence 2:	NP_061176.4	Gene:	DHTKD1 / 55526	HGNCID:	23537	Length:	919	Species:	Homo sapiens

Alignment Length:	870	Identity:	351/870 - (40%)
Similarity:	501/870 - (57%)	Gaps:	73/870 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 DHLAVQAIIRSYQIRGHNIAHLDPLEI------NTPELPGNSSTKSIYANFSFGEQDMDRQFKLP 184
            || .:..::..|...||..|.::||..      |.||:.....|             :...|...
Human    53 DH-GLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQT-------------LQGPFHTA 103

  Fly   185 STTFIGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEKRLI 249
            ....:|.:|||  |:|:|..|..:||.:|.:|...:.|.::.:|..||||......|:.||::.:
Human   104 GLLNMGKEEAS--LEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHL 166

  Fly   250 LARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLNTLA 314
            ...:..:..|:.|||.|:|:.||:|.||.|.|:....|::.:|...|:..||:|||||||||.|.
Human   167 SKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLT 231

  Fly   315 NVCRKPLNQIFTQFAGLEAADD---GSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVDP 376
            .:.:.|...:|.:..||....:   .:|||..||.:.:: |....:..:.:.::.||||||||:|
Human   232 GLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVD-LYFGAHHPLHVTMLPNPSHLEAVNP 295

  Fly   377 VVQGKTRAEQFYRGD---------QEGKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTI 432
            |..||||..|..|.|         |.|.:|:.:.:||||:|||||:|.||..||:||.:...|::
Human   296 VAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSV 360

  Fly   433 HVVANNQIGFTTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVI 497
            |::.|||:|:||.....|||.||:|:.::|...|.|||.|.||.|:...::|.|::..|.||.:|
Human   361 HLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVII 425

  Fly   498 DLVGYRRNGHNEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEE 562
            ||:.||:.||||:|||.:|.|:||:.||..|:..|.||:.|||.|.:|.|||..:.:.|
Human   426 DLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSY------ 484

  Fly   563 AFALAKTETHVK----YKD---WLDSPWSGFFEGKDPLKVAPTGVKEETLIHIGNRFSSPPPNAA 620
               .||...|:.    |:.   .|.:.|.|..:.:..:....|||..:.|..:|.:....|   .
Human   485 ---YAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVP---R 543

  Fly   621 EFVIHKGLLR--VLAARKAMVDEKVADWALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVL 683
            |..:|..||:  |.:..:.|:|....|||..||:|.||||.:|.:||||||||.|||||.||.::
Human   544 ELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIV 608

  Fly   684 HHQLVDKATYNSLQHMYPDQAPY-SVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTA 747
            ..|..|. ||..|.||.|:|..: .||||.|||.||||||:|.|:.:|..|.|||||||||.|.|
Human   609 VCQETDD-TYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGA 672

  Fly   748 QSIIDQFISSGQSKWVRQSGLVMLLPHGMEGMGPEHSSCRVERFLQMSSDDPDYFPPESDEFGVR 812
            |.|.|.|||.|::||:.|||:|:|||||.:|.||:|||||:||||||.         :|.|.||
Human   673 QIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMC---------DSAEEGV- 727

  Fly   813 QLHDINWIVANCSTPANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRII 877
            ....:|..|.:.:|||.|:|:||||:...||||||:.:||.|||.|.|.|...||:.|:.|..:|
Human   728 DGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVI 792

  Fly   878 PDNGPAGQNPSNVKKVVFCSGRVYYDLTKTRRE-KQLEGEIAIVRVEQISPFPFDLVKEQANLYK 941
               |.:..:|..||.:|||||:.:|.|.|.|.. ...:.:.||:|||::.|||.|.::::.:.||
Human   793 ---GDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYK 854

  Fly   942 NA-ELVWAQEEHKNQGSWTYVQPRF 965
            :. :.:|:|||.:|.|.|::|.|||
Human   855 HVKDHIWSQEEPQNMGPWSFVSPRF 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nc73EF	NP_001097629.1	2-oxogl_dehyd_N	51..86	CDD:292696
		sucA	53..1104	CDD:236499	351/870 (40%)
		TPP_E1_OGDC_like	259..521	CDD:238974	116/273 (42%)
		Transket_pyr	645..856	CDD:280874	119/211 (56%)
		OxoGdeHyase_C	863..1102	CDD:293475	40/105 (38%)
DHTKD1	NP_061176.4	OxoGdeHyase_C	58..919	CDD:330401	349/864 (40%)
DHTKD1	NP_061176.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..320		7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D134699at2759
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720