DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nc73EF and OGDH

DIOPT Version :9

Sequence 1:NP_001097629.1 Gene:Nc73EF / 39899 FlyBaseID:FBgn0010352 Length:1105 Species:Drosophila melanogaster
Sequence 2:XP_005249816.1 Gene:OGDH / 4967 HGNCID:8124 Length:1038 Species:Homo sapiens


Alignment Length:1122 Identity:627/1122 - (55%)
Similarity:768/1122 - (68%) Gaps:135/1122 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LSPMAHKNFATWLLKSSSSQQMAKVTAAAAVRTYNS-AAAEPFANGSTASYVEEMYNAWLRDPTS 75
            |.|:.    |:..:|:.|..:.|.......:|.|:: .|||||.:|::::||||||.|||.:|.|
Human    11 LRPLT----ASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKS 71

  Fly    76 VHTSWDAYFRSNSYVSPPNLA---PVQANTLPLTAFNFGGAVAGAAPD-SKTIDDHLAVQAIIRS 136
            ||.|||.:||:.:..:||..|   |:..:...|.|.....::..|.|: .|.::||||||::||:
Human    72 VHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRA 136

  Fly   137 YQIRGHNIAHLDPLEINTPELPGN------SSTK--------------SIYANFSFGEQDMDRQF 181
            ||||||::|.||||.|...:|..:      |||.              ::...:...|.|:|:.|
Human   137 YQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVF 201

  Fly   182 KLPSTTFIGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIRKRFETPGVLNFSPEEK 246
            .||:||||||.|::|||:||:.|||..||..|||||||||.||||.|||::|||||::.|:.|||
Human   202 HLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEK 266

  Fly   247 RLILARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIIDVSTELGVESVIMGMPHRGRLN 311
            |.:||||.|:|.||.||.:|:||||||||||||::|||||.|||.|:|.||:.||||||||||||
Human   267 RTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLN 331

  Fly   312 TLANVCRKPLNQIFTQF-AGLEAADDGSGDVKYHLGTYIERLNRVTNKNIRLAVVANPSHLEAVD 375
            .||||.||.|.|||.|| :.|||||:||||||||||.|..|:||||::||.|::|||||||||.|
Human   332 VLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAAD 396

  Fly   376 PVVQGKTRAEQFYRGDQEGKKVMSILIHGDAAFCGQGVVYETMHLSDLPDYTTHGTIHVVANNQI 440
            |||.|||:|||||.||.|||||||||:||||||.|||:||||.||||||.||||||:|||.||||
Human   397 PVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQI 461

  Fly   441 GFTTDPRFSRSSPYCTDVARVVNAPIFHVNADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRN 505
            |||||||.:|||||.|||||||||||||||:|||||||:|||||||||:|||||.|:|||.||||
Human   462 GFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRN 526

  Fly   506 GHNEIDEPMFTQPLMYQKIRKHKNCLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTE 570
            ||||:|||||||||||::|||.|..|..||:.|:::|.|...|.:...:||:.|||||||.:|.|
Human   527 GHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDE 591

  Fly   571 THVKYKDWLDSPWSGFF--EGKDPLKVAP-TGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVL 632
            ..:..|.||||||.|||  :|:......| ||:.|:.|.||||..||.|  ...|.||.||.|:|
Human   592 KILHIKHWLDSPWPGFFTLDGQPRSMSCPSTGLTEDILTHIGNVASSVP--VENFTIHGGLSRIL 654

  Fly   633 AARKAMVDEKVADWALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQ 697
            ..|..||..:..||||.|.||||||||||||:||||||||||||||||||||.|.|||.|...:.
Human   655 KTRGEMVKNRTVDWALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMN 719

  Fly   698 HMYPDQAPYSVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKW 762
            |::|:||||:|.|||||||.|||||.|::|.:||||||||||||||.||||.||||||..||:||
Human   720 HLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKW 784

  Fly   763 VRQSGLVMLLPHGMEGMGPEHSSCRVERFLQMSSDDPDYFPP-ESDEFGVRQLHDINWIVANCST 826
            |||:|:|:|||||||||||||||.|.||||||.:||||..|. :...|.:.||:|.||:|.||||
Human   785 VRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCST 849

  Fly   827 PANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGPAGQNPSNVK 891
            |.|::|:|||||.||||||||:.|||||||||||:|.|.||..|:.|||:||::|||.|||.|||
Human   850 PGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVK 914

  Fly   892 KVVFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAELVWAQEEHKNQG 956
            :::||:|:||||||:.|:.:.:.|::||.|:||:|||||||:.::...|.||||.|.||||||||
Human   915 RLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQG 979

  Fly   957 SWTYVQPRFLTALNHSRDVSQSDEQSSSTNTTTTTDHTNHESDTDSDSKSKP-WLSRMFAAPNSS 1020
            .:.||:||..|.:                                  |::|| |           
Human   980 YYDYVKPRLRTTI----------------------------------SRAKPVW----------- 999

  Fly  1021 TGGDPKDPAQTLGGDFNAAKHFDLKNVRHDFNRPAGIAAAPGARIAKTGRKISYVGRACGASTAT 1085
                                                                 |.||...|:.||
Human  1000 -----------------------------------------------------YAGRDPAAAPAT 1011

  Fly  1086 GSKAQHIRELNALLNDA 1102
            |:|..|:.||..||:.|
Human  1012 GNKKTHLTELQRLLDTA 1028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nc73EFNP_001097629.1 2-oxogl_dehyd_N 51..86 CDD:292696 21/34 (62%)
sucA 53..1104 CDD:236499 615/1080 (57%)
TPP_E1_OGDC_like 259..521 CDD:238974 210/262 (80%)
Transket_pyr 645..856 CDD:280874 155/211 (73%)
OxoGdeHyase_C 863..1102 CDD:293475 77/239 (32%)
OGDHXP_005249816.1 sucA 49..1030 CDD:236499 615/1080 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141947
Domainoid 1 1.000 492 1.000 Domainoid score I365
eggNOG 1 0.900 - - E1_COG0567
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55662
Inparanoid 1 1.050 1225 1.000 Inparanoid score I188
Isobase 1 0.950 - 0 Normalized mean entropy S586
OMA 1 1.010 - - QHG62893
OrthoDB 1 1.010 - - D134699at2759
OrthoFinder 1 1.000 - - FOG0000624
OrthoInspector 1 1.000 - - otm41679
orthoMCL 1 0.900 - - OOG6_100311
Panther 1 1.100 - - O PTHR23152
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R861
SonicParanoid 1 1.000 - - X894
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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